|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The T1D protective allele DRB1*12:02 was shown to be protective against Graves' disease in our previous report.
|
29383806 |
2018 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Within HLA, some variants of the DRB1, DQA1 and DQB1 genes appear to be possible predictors of the development and recurrence of Graves' disease.
|
30484670 |
2018 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the combinations such as 'DRB1*10+AA' (PL: p=1.8×10<sup>-6</sup>; HT: p=0.003) and 'DRB1*15+AA' (PL: p=0.006; GD: p=0.011) were decreased in patients showing a protective association.
|
29174716 |
2018 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Also, no statistically significant differences were observed after stratifying patients for DRB1*03- or GD-associated variants in CTLA4 or TSHR genes.
|
24289805 |
2014 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We genotyped 991 patients with AITD (547 patients with GD and 444 patients with HT) and 481 control subjects at the HLA-A, HLA-C, HLA-B, DRB1, DQB1, and DPB1 loci.
|
24285682 |
2014 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, our results clearly identify that HLA-DRB1*09:01 confers susceptibility to GD and DRB1*12:02 exerts protection against GD development in Taiwanese children.
|
22731780 |
2012 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Combining the data of two sample populations, we found that B*46:01 (odds ratio under dominant model [OR] = 1.33, Bonferroni corrected combined P [P(Bc)] = 1.17 x 10⁻²), DPB1*05:01 (OR = 2.34, P(Bc) = 2.58 x 10⁻¹⁰), DQB1*03:02 (OR = 0.62, P(Bc) = 1.97 x 10⁻²), DRB1*15:01 (OR = 1.68, P(Bc) = 1.22 x 10⁻²) and DRB1*16:02 (OR = 2.63, P(Bc) = 1.46 x 10⁻⁵) were associated with GD.
|
21307958 |
2011 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Progress has been made in determining association of HLA class II DRB1, DQB1 and DQA1 loci with GD demonstrating a predisposing effect for DR3 (DRB1(*)03-DQB1(*)02-DQA1(*)05) and a protective effect for DR7 (DRB1(*)07-DQB1(*)02-DQA1(*)02).
|
18449200 |
2008 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, there is increasing evidence for a genetic interaction between thyroglobulin variants and DRb1-Arg74 in conferring risk for GD.
|
18178059 |
2008 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The members of maternal pedigree including both affected and unaffected Graves' disease had haplotypes of DRB1*150101 and DQB1*0602, except for the cousin who had DRB1*140301 and DQB1*030101.
|
17785916 |
2007 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The frequencies of DRB1*03 was significantly increased in GD compared to controls (OR = 2.07; 95% CI = 1.24-3.44), whereas DRB1*13 (OR = 0.33; 95% CI = 0.18-0.61) and DRB1*07 (OR = 0.31; 95% CI = 0.13-0.70) were significantly increased in controls compared to patients.
|
17284224 |
2007 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Interaction of HLA-DRB1 alleles with CTLA-4 in the predisposition to Graves' disease: the impact of DRB1*07.
|
16756466 |
2006 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thus, DRB1*1602 allele and closely linked haplotype, DRB1*1602-DQA1*0102-DQB1*0502, might serve as a marker for genetic susceptibility to GD in Asian population.
|
16451208 |
2006 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We detected association of rs2076530 within a large GD dataset [OR = 1.32 (95% CI = 1.14-1.52)], however, linkage disequilibrium (LD) analysis revealed association of rs2076530 to be secondary to the previously established DRB1 exon 2 encoded position beta74 effect although a rare haplotype effect, including both loci, cannot be excluded.
|
16984233 |
2006 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although HLA class II alleles associated with GD in Koreans were different from those in Caucasians, some associations are shared, such as association of DRB1*0301 in male patients and protective effect of DRB1*0701 to GD susceptibility.
|
15993720 |
2005 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
To extend previous results, the amino acid sequence of the exon 2-encoded peptide-binding domain of DRB1 was predicted for each subject, and, by use of logistic regression, each position was analyzed for association with GD.
|
15558498 |
2005 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In patients with Graves' disease alone, the haplotype frequency of DRB1*0803-DQA1*0103-DQB1*0601 were significantly higher than those in controls, suggesting that the susceptibility haplotypes for group B APS III differed from those for Graves' disease alone.
|
16254435 |
2005 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Graves' disease (GD) is associated with HLA-DR3 (DRB1*03) in Caucasians, but the exact amino-acid sequence in the DR beta1 chain conferring susceptibility to GD is unknown.
|
15029234 |
2004 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Stratification analysis revealed no independent association of -308A with GD when the DRB1*03 status was considered.
|
15219383 |
2004 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, after correction for multiple comparisons, the relative risk of HLA-A*0207 susceptibility to Graves' disease remained statistically significant and the haplotype HLA-A*3303 -B*5801 -DRB1*0301 had a significantly protective effect.
|
12694583 |
2003 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
On the other hand, Graves' disease was found to be associated in one of the families with HLA-DR2 (DRB1*1501) and in the other with homozygosity for the HLA-DR7 (DRB*0701) and HLA-DQ2 (DQB1*0201) haplotype.
|
12482195 |
2002 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Case-control association analyses using the probands from our 99 Caucasian families showed an association of GD with DRB1*03 [P = 0.00032, relative risk (RR) = 3.4].
|
12100074 |
2002 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Graves' disease (GD) is associated with the histocompatibility leucocyte antigen (HLA) haplotype A*01-B*0801-DRB1*0301-DQA1*0501-DQB1*0201 (or B8/DR3) whereas autoimmune hypothyroidism (AIH) has been weakly associated with HLA DRB1*03, *04 and *11/*12 alleles (or DR3, DR4 and DR5).
|
11678832 |
2001 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate the presence of the HLA DQA1*0501 and DRB1*0301 antigens in Greek patients with Graves' disease.
|
11263477 |
2001 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The protective alleles for Graves' disease were DRB1 *0901 (0.9% vs. 20.2%; RR = 0.04; Pc < 0.001), DRB1*1001 (0.0% vs. 11%; RR = 0.0%; Pc < 0.01) and DRB4 *0101 (0.0% vs. 12.5%; RR = 0.0; Pc < 0.05).
|
11895223 |
2001 |