|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data indicated that HLA-B*44:03, C*07:01, DQB1*02:02 and DRB1*07:01 were related to OBI infection, whereas HLA-DRB1*08:03, DRB1*15:01 and DQB1*06:02 alleles were associated with HBV DNA clearance in a Shaanxi Han population.
|
28940887 |
2017 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Characterization and genotyping of the DRB1 gene of the major histocompatibility complex (MHC) in the Marmota monax, animal model of hepatitis B.
|
25458311 |
2015 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results revealed that A*02-DRB1*12 and A*02-B*15-DRB1*09 carriers were susceptible to HBV infection.
|
25592155 |
2015 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA-B*15, DRB1*11 and 14 associated with viral clearance in the cases of HBV-C2 infection; HLA-B*54 carriers in chronic group are more sensitive to with the infection of HBV subgenotype B2; HLA-B*07 and DRB1*13 may protect subjects from HBV infection.
|
22056847 |
2012 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
The frequency of LA-DRB1*03 in the CHB patient group was significantly higher compared to that in the asymptomatic hepatitis B carrier patients.
|
22367481 |
2012 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
In male carriers harboring DRB1*1101, the distribution of hepatitis B viral genotype was comparable between the two groups.
|
19235869 |
2009 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
HLA-A, B, and DRB1 alleles in 33 patients with chronic hepatitis B (CHB) and 31 healthy carriers as the persistent group, and 30 subjects who had spontaneously recovered from HBV infection were analyzed by using the polymerase chain reaction (PCR)-sequence-specific primer (PCR-SSP) technique.
|
18761557 |
2008 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
After controlling for pre-booster anti-HBs levels, the absences of HLA-A*02 and -DRB1*08, simply expressed as A*02(-) and -DRB1*08(-), and the presence of B*15 were significantly associated with elevated risks of non-response (post-booster anti-HBs titers<10 mIU/mL) to booster vaccination.
|
18501999 |
2008 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Similar results were got for DRB1*03 and 15 alleles between the HBV-infected patients (n = 108) and 46 HBV seronegative spouses of the HBV patients, who were high-risk group for HBV infection.
|
17257320 |
2007 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Consistent association of DRB1*03 and *07 is observed with HCV susceptibility and non-responsiveness to HBV vaccination across the population.
|
17465466 |
2007 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Compared with other HLA-DRB1 alleles, HLA-DRB1*06, DRB1*08, and DRB1*16 may be associated with chronicity of HBV infection, HLA-DRB1*07 with protection against HBV infection, and HLA-DRB1*14 allele may be associated with a high rate of the response of CHB patients to IFN treatment.
|
16237774 |
2005 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
The frequency of the allele of HLA-DR12 DRB1*1201 was higher in the subjects recovered from hepatitis B infection (32%) than in the patients with chronic hepatitis B (3%; rr, 0.07; Pcorr<0.005).
|
14599975 |
2003 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
For chronic HBV infection per se, DRB1*1302, DQB1*0402, and DQB1*0604 had some protective effect (OR = 0.4, OR = 0.3, and OR = 0.1, respectively), and DRB1*1101 was weakly associated (OR = 4.6) in Koreans.
|
14617034 |
2003 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although hepatitis B vaccination given during the neonatal period does not increase autoantibody production in 6-year-old immunized children, we deem useful a more prolonged follow-up for these nonresponder children carrying certain HLA haplotypes (such as C4AQ0,DRB1*0301,DQB1*02), particularly because most autoimmune diseases do not develop until later in life.
|
12093985 |
2002 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Two HLA class II haplotypes, HLA-[DQB1*0602; DQA1*0102; DR15] and HLA-[DQB1*0603; DQA1*0103; DRB1*1301] were found to be less common in 52 nonresponders compared with 68 responders, P<0.025 and P<0.05 respectively, after vaccination with hepatitis B surface antigen (HBsAg).
|
9820601 |
1998 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Eight of 24 patients (33.3%) who cleared hepatitis B virus spontaneously were positive for DRB1*1301-02 (relative risk of developing chronic infection compared to chronic hepatitis B subjects 0.12; p=0.004).
|
9075656 |
1997 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
The MHC class II allele DRB1*1302 was associated with protection against persistent HBV infection among both children and adults in the Gambia.
|
7898524 |
1995 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data suggest a molecular basis for the differential associations of HLA-DRB1*1301 and DRB1*1302 with resistance to severe malaria and clearance of hepatitis B virus infection.
|
7604034 |
1995 |