|
Sarcoidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the logistic regression models evaluating the association between HLA alleles and chronic sarcoidosis adjusted for rs1049550 and rs2076530, only DRB1*03 was significantly associated with disease resolution.
|
27662826 |
2018 |
|
Sarcoidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Results of in silico binding analyses showed that DRB1*03:01 consistently demonstrated the highest binding affinities for six bacterial peptides previously found in sarcoidosis granulomas, whereas *12:01 displayed the lowest binding affinities.
|
25506722 |
2015 |
|
Sarcoidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Among sarcoidosis patients, the HLA A*23, A*80, B*08, B*41, DQB1*05 and DRB1*14 antigens tended to be more common than in the controls, whereas the B*44, B*45, B*51, B*58, DRB1*15 and DRB1*16 alleles were more frequently found in control subjects than in the sarcoidosis patients.
|
23911360 |
2013 |
|
Sarcoidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the group of patients with chronic sarcoidosis DRB1*11 (P=0.0219; OR=2.44), DRB1*15 (P=0.0414; OR=2.47) demonstrated statistically significant difference in comparison to controls only, while a lower frequency of DRB1*13 (P=0.0156; OR=0.24) in this group was statistically significant when compared to both patients with acute sarcoidosis and controls.
|
21796887 |
2011 |
|
Sarcoidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results support the hypothesis that HLA-A, -B, and -DRB1 polymorphisms may play a role in susceptibility and manifestation of sarcoidosis.
|
21513758 |
2011 |
|
Sarcoidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
ESAT-6 and katG presented by antigen-presenting cells expressing DRB1*1101-induced Th-1 responses from sarcoidosis T cells, thus providing a mechanistic insight for the association of HLA DRB1*1101 with sarcoidosis, and sarcoidosis T cell interaction with microbial antigens.
|
19536643 |
2010 |
|
Sarcoidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Löfgren's syndrome is a common sarcoidosis phenotype in the Dutch and is strongly associated with the DRB1*0301 allele.
|
20685690 |
2010 |
|
Sarcoidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We therefore set out to test the hypothesis that the primary DRB1 15-DQB1 0602 link in sarcoidosis would be to splenomegaly.
|
17875181 |
2007 |
|
Sarcoidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The RAGE coding gene maps to the 6p21.32 region, close to the genes DRB1 and BTNL2, which are associated with sarcoidosis.
|
17170388 |
2007 |
|
Sarcoidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Initially, we studied the association of sarcoidosis with DQB1, and in the present study, we evaluated all amino acid variants of the HLA-DPB1, -DQB1, -DRB1, -DRB3, -DRB4 and -DRB5 genes to identify possible polymorphisms associated with the disease.
|
17559577 |
2007 |
|
Sarcoidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The association of the HSP(+2437)-C allele with sarcoidosis and LS appeared to be independent of the presence of DRB1*03, although this HLA specificity was associated with LS manifestation.
|
16611259 |
2006 |
|
Sarcoidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
DQB1*02, DQA1*0201/*0501 (Ls) and DRB1*15/*13 (Stage II) were more frequently present in SA than in TB, but after correction, only DRB1*15, DQB1*02, DQA1*0501 were significantly different.
|
18038917 |
2006 |
|
Sarcoidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recent studies in sarcoidosis have identified association of a single nucleotide polymorphism (SNP) rs2076530 within BTNL2, a potential T-cell inhibitor, independent of the known DRB1 association.
|
16984233 |
2006 |
|
Sarcoidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition, we found a highly significant correlation of HLA-DRB1*11 or -DRB1*15 alleles and/or the presence of M. tuberculosis DNA to a chronic disease course, whereas HLA-DRB1*03 or -DRB1*04 alleles combined with the absence of M. tuberculosis DNA were associated with an acute sarcoidosis (p = 0.009).
|
15881283 |
2005 |
|
Sarcoidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The overrepresentation of TNF-308*A, LTAlpha+252*G and HLA-DRB1*03 allele carriers was found in a subgroup of sarcoidosis patients presenting with Lofgren's syndrome (LS) by comparison with the subgroup of patients without LS (NLS; phenotype frequency LS vs NLS: 68.8 vs 37.1% for TNF-308*A, 93.8 vs 66.3% for LTA+252*G and 68.8 vs 21.3% for DRB1*03).
|
15713215 |
2005 |
|
Sarcoidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, we also showed the presence of a combined association between DRB1*03 and IFN-gamma 3,3 in sarcoidosis (P = 0.017) and LS patients (P = 0.001).
|
15019280 |
2004 |
|
Sarcoidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Further, multivariate logistic regression analysis revealed that the presence of DRB1*11(odds ratio [OR] 9) and DRB1*14 (OR 7), and absence of DRB1*07 (OR 63 and DQB1*0201(OR 3) alleles, were independent predictors of sarcoidosis.
|
12600814 |
2003 |
|
Sarcoidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition to being susceptibility markers, HLA class II alleles may be markers for different phenotypes of sarcoidosis (DRB1*0401 for eye in blacks and whites, DRB3 for bone marrow in blacks, and DPB1*0101 for hypercalcemia in whites).
|
14508706 |
2003 |
|
Sarcoidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA-DRB3*0101 as well as DRB1*0301 positive sarcoidosis patients may have the capacity to present specific sarcoidosis associated antigens in such a way that AV2S3+ CD4+ T cells are stimulated preferentially, generating lung restricted AV2S3+ T cell expansions.
|
11923555 |
2002 |
|
Sarcoidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Conversely, a lack of DRB1*11 and/or DRB1*12 but not DRB3*0201/2 favored the clinical course of sarcoidosis.
|
11169267 |
2001 |
|
Sarcoidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These studies support the thesis that one of the major genetic factors controlling the development of sarcoidosis is located within the DRB1 locus in the HLA class II region.
|
9349405 |
1997 |
|
Sarcoidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sarcoidosis is a systemic granulomatous disease and the DRB1 gene of the DR subregion has been implicated for determining the genetic susceptibility to the disease.
|
9062964 |
1997 |
|
Sarcoidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our finding of a high frequency of DRB1*08 (which lacks the DRB3 gene encoding the DR52 antigen) in patients living in both eastern Japan and in Hokkaido, confirms that it is the HLA-DRB1 locus, rather than that of the HLA-DRB3, -DQA1, or -DQB1, which determines the susceptibility to sarcoidosis.
|
9130059 |
1996 |
|
Sarcoidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The significantly increased frequency of the DR8 (DRB1*08) haplotype, which lacks the DRB3 gene encoding DR52 antigen, suggested that the DR5 (DRB1*11), DR6 (DRB1*14) and DR8 (DRB1*08) of the DRB1 alleles may determine the susceptibility to sarcoidosis among the Japanese.
|
8739505 |
1996 |
|
Sarcoidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Susceptibility to the development of sarcoidosis has been demonstrated to be associated with HLA-DR5, -DR6, and -DR8 encoded by the DRB1 gene.
|
7742275 |
1995 |