RBM45, RNA binding motif protein 45, 129831

N. diseases: 557; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker disease BEFREE However, many class II HLA-DR variants were found to be associated with M. tuberculosis but not M. africanum with the exception of the DRB1*03:01, which was associated with both groups. 30516034 2019
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker disease BEFREE Thus, our data indicate that DRB1*03 and DRB1*07 may provide protective effects against TB susceptibility. 26634553 2015
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 GeneticVariation disease BEFREE Furthermore, we found that these less-protective DRB1 alleles are found at a very high frequency in several populations with a high burden of tuberculosis. 20353587 2010
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 GeneticVariation disease BEFREE The presence of DRB1 shared alleles between primary cases and their contacts was a risk factor for tuberculosis (p=0.0281). 19692729 2010
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 GeneticVariation disease BEFREE We used the polymerase chain reaction with sequence specific primer method to study the DRB1* locus in 147 Syrian patients with positive sputum smear or sputum culture for Mycobacterium Tuberculosis strains, and 209 Syrian healthy matching individuals with negative tuberculin skin test. 18998014 2008
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 GeneticVariation disease BEFREE Only DRB1*1101-1121-DQB1*05 was significantly associated with TB based on the sequential Bonferroni p value. 16916662 2006
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker disease BEFREE DQB1*02, DQA1*0201/*0501 (Ls) and DRB1*15/*13 (Stage II) were more frequently present in SA than in TB, but after correction, only DRB1*15, DQB1*02, DQA1*0501 were significantly different. 18038917 2006
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 GeneticVariation disease BEFREE It is suggested that DRB1*0803 and DQB1*0601 alleles are associated with disease progression of TB in Koreans, exerting influence on the development of drug resistance, severe disease, and recurrent disease. 16386650 2005
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 GeneticVariation disease BEFREE It seems likely that the presence of DRB1*1601, DQB1*0502 alleles and DRB1*1601-DQB1*0502, DRB1*04-DQB1*03, DRB1*14-DQB1*05 haplotypes may be related to a higher risk of developing TB, whereas low frequency of DQB1*0201 and DRB1*11-DQB1*03 haplotype may be linked to the resistance to TB. 15958261 2005
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker disease BEFREE A four-way nested classification analysis revealed that TCR V beta family 1, 5, 9, 12, and 13 usage in the context of HLA class II high-risk alleles (DRB1*1501, DRB1*08, and DQB1*0601) and Mycobacterium bovis BCG scar status were the determining factors in susceptibility and resistance to tuberculosis. 12874334 2003
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker disease BEFREE Association of high HIV-1 RNA levels and homozygosity at HLA class II DRB1 in adults coinfected with Mycobacterium tuberculosis in Harare, Zimbabwe. 12392855 2002
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 GeneticVariation disease BEFREE Our recent studies in this endemic region have reiterated the association of HLA-DRB1*02 and its subtype DRB1*1501 with tuberculosis susceptibility and have identified an IL-10 associated disease susceptibility in HLAnon-DRB1*02, BCG scar negative individuals and a skewed usage of TCR Vb in BCG scar negative, HLA high risk allele carrying individuals. 12501922 2002
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 GeneticVariation disease BEFREE The highest relative risk (RR) of tuberculosis was associated with DRB1*16 alleles (RR = 9.7). 11179915 2000
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 GeneticVariation disease BEFREE The HLA class II allele, DR2 (DRB1*1501), has been repeatedly found to be associated with development of tuberculosis and leprosy. 10703603 2000