Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, many class II HLA-DR variants were found to be associated with M. tuberculosis but not M. africanum with the exception of the DRB1*03:01, which was associated with both groups.
|
30516034 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, our data indicate that DRB1*03 and DRB1*07 may provide protective effects against TB susceptibility.
|
26634553 |
2015 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, we found that these less-protective DRB1 alleles are found at a very high frequency in several populations with a high burden of tuberculosis.
|
20353587 |
2010 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The presence of DRB1 shared alleles between primary cases and their contacts was a risk factor for tuberculosis (p=0.0281).
|
19692729 |
2010 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We used the polymerase chain reaction with sequence specific primer method to study the DRB1* locus in 147 Syrian patients with positive sputum smear or sputum culture for Mycobacterium Tuberculosis strains, and 209 Syrian healthy matching individuals with negative tuberculin skin test.
|
18998014 |
2008 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Only DRB1*1101-1121-DQB1*05 was significantly associated with TB based on the sequential Bonferroni p value.
|
16916662 |
2006 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
DQB1*02, DQA1*0201/*0501 (Ls) and DRB1*15/*13 (Stage II) were more frequently present in SA than in TB, but after correction, only DRB1*15, DQB1*02, DQA1*0501 were significantly different.
|
18038917 |
2006 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
It is suggested that DRB1*0803 and DQB1*0601 alleles are associated with disease progression of TB in Koreans, exerting influence on the development of drug resistance, severe disease, and recurrent disease.
|
16386650 |
2005 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
It seems likely that the presence of DRB1*1601, DQB1*0502 alleles and DRB1*1601-DQB1*0502, DRB1*04-DQB1*03, DRB1*14-DQB1*05 haplotypes may be related to a higher risk of developing TB, whereas low frequency of DQB1*0201 and DRB1*11-DQB1*03 haplotype may be linked to the resistance to TB.
|
15958261 |
2005 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
A four-way nested classification analysis revealed that TCR V beta family 1, 5, 9, 12, and 13 usage in the context of HLA class II high-risk alleles (DRB1*1501, DRB1*08, and DQB1*0601) and Mycobacterium bovis BCG scar status were the determining factors in susceptibility and resistance to tuberculosis.
|
12874334 |
2003 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Association of high HIV-1 RNA levels and homozygosity at HLA class II DRB1 in adults coinfected with Mycobacterium tuberculosis in Harare, Zimbabwe.
|
12392855 |
2002 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our recent studies in this endemic region have reiterated the association of HLA-DRB1*02 and its subtype DRB1*1501 with tuberculosis susceptibility and have identified an IL-10 associated disease susceptibility in HLAnon-DRB1*02, BCG scar negative individuals and a skewed usage of TCR Vb in BCG scar negative, HLA high risk allele carrying individuals.
|
12501922 |
2002 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The highest relative risk (RR) of tuberculosis was associated with DRB1*16 alleles (RR = 9.7).
|
11179915 |
2000 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The HLA class II allele, DR2 (DRB1*1501), has been repeatedly found to be associated with development of tuberculosis and leprosy.
|
10703603 |
2000 |