RBM45, RNA binding motif protein 45, 129831

N. diseases: 557; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 Biomarker disease BEFREE HLA-B*15 showed a negative association with HPV-16-positive CaCx (0.1, 0.01), whereas DRB1*04 exhibited protection to both HPV-16-positive CaCx and persistent HPV-16 infection (0.3, 0.0001 and 0.1, 0.0002, respectively). 31800372 2019
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 Biomarker disease BEFREE Human Leukocyte Antigen (HLA) Class II -DRB1 and -DQB1 Alleles and the Association with Cervical Cancer in HIV/HPV Co-Infected Women in South Africa. 31258717 2019
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 GeneticVariation disease BEFREE Further, protective associations were evidenced for alleles B*35 and DRB1*10 and haplotypes A*11-B*35 and DRB1*10-DQB1*0501 with cervical cancer in South India. 27268619 2016
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 GeneticVariation disease BEFREE Human leukocyte antigen class II DRB1*1302 allele protects against cervical cancer: At which step of multistage carcinogenesis? 26235935 2015
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 GeneticVariation disease BEFREE Haplotype analysis highlighted the significant association of HLA- DRB1*07:01-DQB1*02:02 and HLA DRB1*10:01-DQB1*05:01 with cervical cancer, while HLA-DRB1*14:04-DQB1*05:03 and DRB1*15:01-DQB1*06:01 conferred decreased risk for cervical cancer. 25673541 2014
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 GeneticVariation disease BEFREE Among the 25 specific alleles, six (DRB1*0301, *0403,*0404, *0803, *1312 and *1502) were associated with an increased risk cervical cancer in all studies. 24551099 2014
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 GeneticVariation disease BEFREE Variation in LD between the classic HLA loci, rs9272143 and rs67841474 between populations may explain the different associations of HLA-B*07 and DRB1*1501-DQB1*0602 with cervical cancer between studies. 24520070 2014
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 GeneticVariation disease BEFREE We also confirmed previously reported associations of B*0702 and DRB1*1501-DQB1*0602 with susceptibility to and DRB1*1301-DQA1*0103-DQB1*0603 with protection against cervical cancer. 23482656 2013
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 GeneticVariation disease BEFREE Consistent associations across other studies in women with CC and infected by HPV16 were observed for HLA-DRB1*15 (OR, 3.9; 95% CI, 1.6-10.2) and the haplotype DRB1*15 DQB1*0602 (OR, 4.1; 95% CI, 1.4-12.7) compared with control women. 19820376 2009
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 GeneticVariation disease BEFREE The DRB1*13 allele/DRB1*13-DQB1*06 haplotype was strongly protective against risk to HPV infection (p(c) < 0.002) as well as cervical cancer (p(c) 0.01). 19272325 2009
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 GeneticVariation disease BEFREE In a similar fashion, the occurrence of DRB1 *13-DQB1 *06 (OR, 0.17; 95% CI, 0.04-0.80) haplotype was significantly lower in the study patients compared with the controls and may confer a decreased risk of CC among Han race population in the Guangdong Province of China. 19027490 2008
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 GeneticVariation disease BEFREE Accordingly, a specific MHC class II haplotype, DRB1*0901-DQB1*03032, may be a risk factor for cervical carcinoma in the Japanese population. 17433060 2008
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 Biomarker disease BEFREE These results indicate that HLA-DPB1*1301 may confer susceptibility to cervical cancer, and the haplotypes DRB1*150101-DQB1*0602 and DRB1*070101-DQB1*0201 may contribute to the resistance to the development of cervical cancer among Chinese women. 17349874 2007
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 GeneticVariation disease BEFREE We find that carriers of the commonly reported protective DRB1*1301 and DQB1*0603 alleles have lower HPV 18/45 load compared to noncarriers and a lower risk of developing HPV 18/45-positive cervical carcinoma. 15906352 2005
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 GeneticVariation disease BEFREE The strongest class II effects are coming from the DQB1 and DRB1 loci, but the DPB1 locus also contributes to the susceptibility to cervical cancer. 15238505 2004
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 Biomarker disease BEFREE Observations from this study confirm earlier findings of a negative association between DRB1*13 and cervical cancer and suggest that specific DRB1-DQB1 haplotype combinations, rather than individual DQB1*03 alleles, increase the risk for cervical cancer. 11588129 2001
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 GeneticVariation disease BEFREE We have examined the association of variation at the DRB1 and DQB1 loci with HPV16 infection and risk of development of cervical cancer by analysis of 440 cases diagnosed with cervical cancer in situ and 476 age-matched controls in a retrospective case-control study. 11519043 2001
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 Biomarker disease BEFREE In previous studies, the HLA class II haplotype HLA DRB1*0401-DQB1*0301 was shown to correlate with susceptibility to HPV infection, CIN and cervical cancer while DRB1*0101-DQB1*0501 indicated protection. 11562779 2001
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 Biomarker disease BEFREE DQB1*0301 alone (2P = 0.02) and in combination with DRB1*0401 (2P = 0.02) was found to be associated with cervical cancer. 10755413 2000
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 GeneticVariation disease BEFREE The distribution of HLA class II DRB1 and DQB1 alleles in cervical carcinoma patients was compared with the frequency of these alleles found in healthy population living in the Czech Republic. 10732716 1999
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 GeneticVariation disease BEFREE The association of HLA class II DQB1 and DRB1 alleles with the development of cervical carcinoma was studied in 150 Swedish patients using PCR-based HPV and HLA typing. 8864172 1996