|
Autoimmune hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Increased frequencies of both HLA-DRB1*04:04:01 and *16:02:01:01 alleles (OR = 2.91; 95% CI = 1.08-7.84) and the haplotype (DRB1-TNFA-LTA) *04:04:01-G-A (OR = 5.33; 95% CI = 1.32-21.49) were observed in AIH patients.
|
31570816 |
2019 |
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The frequency of deleterious alleles in TNFAIP3 was higher in the AIH subset without the DRB1 risk alleles than that with (P = 0.0052, OR 5.10, 95%CI 1.55-16.74).
|
31138864 |
2019 |
|
Autoimmune hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
DRB1*03:01 was singly associated with AIH among whites (odds ratio [OR]: 3.09, P = 0.002) and carriers of DRB1*03:01 also carried DQA*05:01 and DQB1*02:01.
|
31211758 |
2019 |
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The C allele of rs7708392 was associated with AIH, especially AIH without DRB1*04:05, an already established risk factor.
|
29559739 |
2018 |
|
Autoimmune hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The predisposing association of DRB1*04:01 (P = 0.0006, corrected P [Pc] = 0.0193, odds ratio [OR] 2.97, 95% confidence interval [CI] 1.62-5.43), DRB1*04:05 (P = 1.89×10-21, Pc = 5.86×10-20, OR 3.41, 95% CI 2.65-4.38), and DQB1*04:01 (P = 4.66×10-18, Pc = 6.99×10-17, OR 3.89, 95% CI 2.84-5.33) and the protective association of DRB1*13:02 (P = 0.0003, Pc = 0.0080, OR 0.48, 95% CI 0.32-0.72) with Japanese type 1 AIH were observed.
|
29088299 |
2017 |
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The presence of HLA alleles B*08:01, C*07:01, DRB1*03:01, DQB1*02:01 and possibly A*01:01 enhances the risk of AIH (type 1) in Spanish patients.
|
27206238 |
2016 |
|
Autoimmune hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, DRB1(∗)11 was less frequent in AIH patients.
|
26780502 |
2016 |
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Two types of autoimmune hepatitis are justified by serological markers, but they also have distinctive genetic associations (DRB1 and DQB1 genes) and autoantigens.
|
25999246 |
2015 |
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The DRB1*04:05-DQB1*04:01 haplotype was significantly associated with AIH susceptibility (30% vs. 11%, P = 1.2×10(-10); odds ratio [OR] = 3.51) and correlated with elevated serum IgG (3042 vs. 2606 mg/dL, P = 0.041) and anti-smooth muscle antigen positivity (77% vs. 34%, P = 0.000006).
|
24956105 |
2014 |
|
Autoimmune hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
On the other hand, frequencies of A32 and DRB1*04 were high among patients with unclassified autoimmune hepatitis.
|
21480110 |
2011 |
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recently, molecular analysis using polymerase chain reaction (PCR)-based DNA typing has revealed that susceptibility to type 1 AIH is primarily associated with the HLA class II DRB1 locus, which encodes a polymorphic β chain of the HLA-DR antigen.
|
20957499 |
2011 |
|
Autoimmune hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Human leucocyte antigen typing revealed DRB1*03 heterozygosity, which has been associated with the occurrence of both autoimmune hepatitis and type 1 diabetes.
|
22797478 |
2010 |
|
Autoimmune hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
By high-resolution analysis, the frequencies of DRB1 *0405 and DQB1 *0401 were significantly increased in patients with AIH (P = 0.0001, OR = 3.74; P = 0.00006, OR = 3.95, respectively).
|
18022727 |
2008 |
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CD4 T cells from patients with type 2 AIH positive for the predisposing HLA allele DRB1*0701 recognize seven regions of CYP2D6, five of which are also recognized by CD8 T cells.
|
18528928 |
2008 |
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our data indicate that type 1 AIH predisposition in a Venezuelan mestizo population of different ethnic backgrounds is associated with DRB1*1301 and DRB1*0301 alleles.
|
17927716 |
2007 |
|
Autoimmune hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA DRB1*03-DRB1*04 is a risk factor for type-1 autoimmune hepatitis, and its impact on outcome relates to the diversity of DRB1*04 alleles that encode a critical motif.
|
17105585 |
2006 |
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Among the HLA DRB1 alleles, DRB1*0301 (20% vs 6.19%; P = 0.03), DRB1*1301 (15% vs 2.65%; P = 0.01), DRB1*14 (30% vs 11.5%; P = 0.02) and DRB1*1501 (40% vs 22.12%; P = 0.08) were increased in AIH patients when compared with the controls.
|
15683420 |
2005 |
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Studies of type 1 AIH have focused on the major histocompatibility complex (MHC), mapping susceptibility to the DRB1 region.
|
12447707 |
2002 |
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The DRB1*0405-DQB1*0401 haplotype in autoimmune pancreatitis showed no significant association with any HLA class I antigens, in contrast to the B54-DRB1*0405-DQB1*0401 haplotype reported in autoimmune hepatitis.
|
11984513 |
2002 |
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In subtypes of DR4, there was a trend of increase in the gene frequency of DRB1 0405 in patients with AIH versus healthy controls (21.9% vs 6.3%, P=0.04, but P(c) =0.08).
|
11819862 |
2001 |
|
Autoimmune hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The principal HLA alleles associated with type 1 autoimmune hepatitis in Britain and North America are DRB1*0301 and DRB1*0401.
|
10807521 |
2000 |
|
Autoimmune hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic susceptibility to type 1 autoimmune hepatitis is indicated by a preponderance of female subjects and strong associations with human leukocyte antigens (HLA) DRB1*0301 and DRB1*0401.
|
10613727 |
2000 |
|
Autoimmune hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We report on a 55-year-old woman in whom AIH developed during the convalescence period of serologically proven acute viral hepatitis type A. HLA class II DRB1*0401, which was reported to be associated with AIH with a moderate coarse and late appearance in life, was found in this patient.
|
10548341 |
1999 |
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Comparison of DRB1*13- and DRB1*03-positive subjects revealed that the former alleles conferred susceptibility to younger patients with AIH type 1.
|
10406258 |
1999 |
|
Autoimmune hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
A significant association of autoimmune hepatitis with DRB1*0404 was found, (chi2Y=19.95, pc=0.002, RR=7.71), suggesting the presence of a susceptibility gene located at the DRB1 locus.
|
9672174 |
1998 |