Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
In the present study, we further elucidate the impact of COMT in treatment response in MDD patients with suicide risk and/or a personal history of suicide attempts.
|
21940152 |
2012 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Catechol-O-methyltransferase genotype as modifier of superior responses to venlafaxine treatment in major depressive disorder.
|
23706899 |
2013 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the present study, the effect of COMT val158met on response to electroconvulsive therapy (ECT) was analyzed in a sample of 104 Caucasian patients (f = 71, m = 33) with pharmacologically treatment-resistant Major Depression.
|
19309019 |
2010 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, we partially replicated our previous findings confirming a possible influence of COMT variants in MD and BD, particularly in early onset subjects, though not with the same risk genotypes.
|
21600957 |
2011 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The goal of our work is to study the possible effect of clinical variables, neuropsychological performance, and the 5HTTLPR, the rs25531 of the SLC6A4 gene, and the val108/58Met of the COMT gene polymorphisms on the prediction of the speed of remission in MDD patients.
|
23787408 |
2013 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
COMT Val158met polymorphism was genotyped in 334 Chinese major depressive disorder (MDD) patients who were treated with fluoxetine for at least 4 weeks.
|
18533273 |
2009 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To overcome the problem of poor sample size detecting genes of small effect, we perform a meta-analysis of the current literature, investigating the influence of the COMT Val158Met polymorphism on the pathogenesis of MDD, with a major focus on the effect of gender.
|
26813412 |
2016 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Sixteen SNPs in the COMT gene were investigated in 123 outpatients with major depression.
|
24814141 |
2014 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Monoamine oxidase a and catechol-o-methyltransferase functional polymorphisms and the placebo response in major depressive disorder.
|
19593178 |
2009 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This article presents associations of the COMT pain sensitivity haplotype and baseline pain levels in female patients with MDD.
|
20627703 |
2010 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Catechol-o-methyltransferase (COMT) and proline dehydrogenase (PRODH) mRNAs in the dorsolateral prefrontal cortex in schizophrenia, bipolar disorder, and major depression.
|
14618678 |
2004 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We could not demonstrate any significant difference in the distribution of this COMT single-nucleotide polymorphism (SNP) in the treatment response to selective serotonin reuptake inhibitors or between patients with MDD and control subjects.
|
20071037 |
2010 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
A total of 26 outpatients with treatment-resistant MDD and 27 matched healthy controls underwent magnetic resonance imaging and genotyping for six SNPs in monoaminergic genes [serotonin transporter (SLC6A4), norepinephrine transporter (SLC6A2), serotonin 1A and 2A receptors (HTR1A and HTR2A), catechol-O-methyltransferase (COMT), and brain-derived neurotrophic factor (BDNF)].
|
25990886 |
2015 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
DTI and genotyping for the COMT val158met gene (rs4680) polymorphism were conducted to determine the impact of COMT polymorphisms on white matter changes in patients with MDD.
|
23618651 |
2013 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of our work is to study the possible role of clinical variables, neuropsychological performance, and the 5HTTLPR, rs25531, and val108/58Met COMT polymorphisms in the prediction of the response to fluoxetine after 4weeks of treatment in a sample of patient with MDD.
|
20584552 |
2010 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Lack of influence of rs4680 (COMT) and rs6276 (DRD2) on diagnosis and clinical outcomes in patients with major depression.
|
24555772 |
2014 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The current study is a preliminary investigation of the association of polymorphisms of the serotonin transporter (SLC6A4), dopamine transporter (DAT1), dopamine receptor D4 (DRD4), and catechol-O-methyl transferase (COMT) genes with theory of mind decoding in a sample of adults with major depression.
|
26974654 |
2016 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Further post-hoc tests showed a nonlinear modulation effect of COMT on gFCD in the development of MDD.
|
28728097 |
2017 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We examined whether the COMT gene, which has been known to play a role in antidepressant treatment response in major depressive disorder (MDD), has a pharmacogenetic effect in antidepressant treatment response in GAD.
|
22417933 |
2012 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Investigating the impact of COMT on suicidal behaviour, we found a significant association with suicide risk in MDD patients not responding to antidepressant treatment, but not in responders.
|
22464339 |
2012 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Expressions of NMDAR-related genes including SRR, SHMT2, PSAT1, GCAT, GAD1, SLC1A4, NRG1 and COMT in peripheral WBCs of 110 patients with MDD (25 drug-naïve, 21 drug-free, and 64 medicated patients) and 125 healthy individuals were measured using quantitative PCR.
|
30699855 |
2019 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
rs4680 in COMT and rs3219151 in GABRA6 showed positive associations with PD and MDD.
|
25974322 |
2015 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We have prospectively demonstrated the relationship between the single-nucleotide polymorphism of the Val158Met COMT gene (rs4680) and the hippocampal subfields in drug-naive MDD patients.
|
31239688 |
2019 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Moreover this genotype resulted in epistasis with COMT Met carriers in association with MDD.
|
26021967 |
2015 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our aim was to assess the effect of accumulation of specific SERT, BDNF and COMT gene functional polymorphisms on brain structure in MDD patients.
|
26956059 |
2016 |