|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Previous research has indicated that variation in genes encoding catechol-O-methyltransferase (<i>COMT</i>) and dopamine receptor D2 (<i>DRD2</i>) may influence cognitive function and that this may confer vulnerability to the development of mental health disorders such as schizophrenia.
|
28523234 |
2017 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This study is the first to date examining the impact of AUDs/SUDs and COMT variants on FER in an epidemiologically representative sample of subjects with schizophrenia.
|
28913946 |
2017 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We report that the variation in gene sequence at the four COMT SNPs studied was not associated with an altered the risk of schizophrenia but genotype at rs4680 and rs4818, but not rs165519 and rs737865, were associated with varying levels of cortical CHRM1 expression in the human dorsolateral prefrontal cortex (DLPFC).
|
26954460 |
2016 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that variation of the COMT gene is associated with treatment response regarding negative symptoms and prolactin changes after amisulpride treatment in patients with schizophrenia.
|
26724569 |
2016 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
There was a significant interaction between peripheral proline and COMT on negative symptoms in schizophrenia (P<0.0001, n=95).
|
27622935 |
2016 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Searches using PubMed, Web of Science, and PsycInfo databases (03/01/2015) yielded 23 studies investigating COMT Val158Met variation and antipsychotic response in schizophrenia and schizo-affective disorder.
|
26745992 |
2016 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genotypic variations in the functional polymorphism Val(158)Met COMT appear to have an impact in dopamine signaling in the PFC of healthy subjects and schizophrenia patients.
|
27421706 |
2016 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
COMT val158met polymorphism and molecular alterations in the human dorsolateral prefrontal cortex: Differences in controls and in schizophrenia.
|
27021555 |
2016 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Large and rare CNVs as well as low-frequency CNVs and relatively small CNVs, namely <30 kb in COMT, may be genetic risk factors for schizophrenia.
|
26852906 |
2016 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
The pooled results from the meta-analysis (15,565 cases and 17,251 healthy subjects) after the elimination of heterogeneity showed an association between COMT Val108/158Met and schizophrenia [recessive model: OR 1.08 CI 95 % (1.01-1.15)].
|
27020768 |
2016 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Genetic studies indicate that disrupted-in-schizophrenia-1 (DISC1), brain-derived neurotrophic factor (BDNF), and catechol-O-methyl transferase (COMT) genes might be implicated in the etiology of schizophrenia, but not in all populations.
|
27285059 |
2016 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
COMT-Val is a putative risk factor in schizophrenia, which is characterized by disordered prefrontal function.
|
26649915 |
2016 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The COMT Val158Met polymorphism moderates the association between cognitive functions and white matter microstructure in schizophrenia.
|
26999687 |
2016 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The current study was designed to investigate the role of COMT Val(108/158)Met polymorphism in development, sensory gating deficit, and symptoms of schizophrenia in Han Chinese population.
|
27315458 |
2016 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Notably, select single-nucleotide polymorphisms (SNPs) of the COMT gene have been implicated in schizophrenia risk, severity, and treatment response.
|
27228319 |
2016 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Does COMT val158met polymorphism influence P50 sensory gating, eye tracking or saccadic inhibition dysfunctions in schizophrenia?
|
27825784 |
2016 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The relationship between catechol-O-methyltransferase gene Val158Met (COMT) polymorphism and premorbid cannabis use in Turkish male patients with schizophrenia.
|
25600541 |
2015 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Many susceptible genes have been identified in schizophrenia such as catechol-O-methyltransferase (COMT) and serine/threonine kinase (AKT1).
|
25801838 |
2015 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Here we contrasted the effects of complex COMT haplotypes with the ValMet polymorphism on cognitive functions and their interaction with menopause, in healthy subjects and patients with schizophrenia.
|
26560201 |
2015 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Since recent studies in patients affected by neurodegenerative and psychiatric disorders suggested a role of saitohin (STH) gene as a concurring factor in hypofrontality, we hypothesize that STH and COMT polymorphisms could have an additive effect on cognition in schizophrenia.
|
25283873 |
2015 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Catechol-O-methyltransferase (COMT) is a candidate susceptibility gene for schizophrenia that is involved in the regulation of dopamine in the prefrontal cortex.
|
25722988 |
2015 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In this study, we explored the relationship between the Val158Met polymorphism of the COMT gene and the GMV/cortical thickness/cortical surface area in 150 first-episode treatment-naïve patients with schizophrenia and 100 healthy controls.
|
25564193 |
2015 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
In each case, a single gene is represented in a plurality of epistatic interactions, apolipoprotein E (APOE) for AD and catechol-O-methyltransferase for schizophrenia.
|
25403528 |
2015 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
COMT genotype and response to cognitive remediation in schizophrenia.
|
26255563 |
2015 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
In this invited review, we consider the current status of 25 historical candidate genes for schizophrenia (for example, COMT, DISC1, DTNBP1 and NRG1).
|
25754081 |
2015 |