|
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These findings seem to indicate a role of COMT polymorphisms in regulating cognitive functioning in patients with BD.
|
30146088 |
2019 |
|
Bipolar Disorder
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The methylation level of COMT and PPIEL gene is closely related to bipolar disorder.
|
29565503 |
2018 |
|
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Sixty-four outpatients with BD in full or partial remission were stratified according to COMT Val158Met genotype (ValVal [n=13], ValMet [n=34], and MetMet [n=17]).
|
28544426 |
2017 |
|
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
The catechol-O-methyltransferase (COMT) gene has been a candidate gene for BD.
|
27930497 |
2017 |
|
Bipolar Disorder
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Nevertheless, the specific relevance of COMT enzymatic activity in the pathophysiology of BD and schizophrenia dimensions remains elusive.
|
27458023 |
2017 |
|
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
Stressful life events and catechol-O-methyl-transferase (COMT) gene in bipolar disorder.
|
28102561 |
2017 |
|
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Catechol-O-methyltransferase Val(108/158)Met polymorphism affects fronto-limbic connectivity during emotional processing in bipolar disorder.
|
28049082 |
2017 |
|
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These data indicate a significant interaction between peripheral proline and COMT genotype, influencing negative symptoms in schizophrenia and bipolar disorder.
|
27622935 |
2016 |
|
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
This study supports the hypothesis the interaction of the dopaminergic genes between BP-II(+AD) and BP-II(-AD) is significant different,, and provides additional evidence that the DRD2TaqIA A1/A1, ALDH2*1/*1 and COMT genes interact in BP-II(-AD) but not in BP-II(+AD).
|
25430946 |
2015 |
|
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
PSYGENET |
Because dopaminergic disturbance is thought to be involved in the development of bipolar disorder (BPD), it seems essential to investigate dopamine-related genes like the catechol-O-methyltransferase (COMT) gene, which are involved in dopamine metabolism, and the methylenetetrahydrofolate reductase (MTHFR) gene, which may affect COMT methylation and COMT function.
|
25744938 |
2015 |
|
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This work first showed the association of combined Leu136Leu and Val158Met variants of COMT gene with MDD and BD.
|
25766270 |
2015 |
|
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
PSYGENET |
Genotyping for COMT polymorphisms was carried out by DNA direct sequencing in 112 patients (54 MDD and 58 BD) and 58 healthy subjects.
|
25766270 |
2015 |
|
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
Monoaminergic dysfunction has been implicated in the pathogenesis of BP, it may be important to investigate genes such as the catechol-O-methyltransferase (COMT), involved in monoamine metabolism and brain-derived neurotrophic factor (BDNF) genes, modulating the monoamine system.
|
23026378 |
2013 |
|
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
PSYGENET |
The negative effects of antipsychotics on cognitive functioning in bipolar disorder may be moderated by the COMT Val 108/158 Met genotype, with a negative effect of Val allele load.
|
23421957 |
2013 |
|
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Cognitive manic symptoms in bipolar disorder associated with polymorphisms in the DAOA and COMT genes.
|
23861766 |
2013 |
|
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
PSYGENET |
Cognitive manic symptoms in bipolar disorder associated with polymorphisms in the DAOA and COMT genes.
|
23861766 |
2013 |
|
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This is the first study suggesting that COMT rs4680 modulates FER differently during BD episodes and in healthy controls.
|
22222175 |
2012 |
|
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
PSYGENET |
A gene coexpression network was developed based on a mutual information approach including four candidate genes (NRG1, DISC1, BDNF and COMT) along with other coexpressing genes in unipolar disorder, bipolar disorder and schizophrenia.
|
22777684 |
2012 |
|
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Allele G from COMT SNPs rs4680 and rs165599 may represent reliable state-dependent predictors of global CD during manic and mixed episodes in BD.
|
22713126 |
2012 |
|
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The impact of the Val158Met catechol-O-methyltransferase genotype on neural correlates of sad facial affect processing in patients with bipolar disorder and their relatives.
|
20667170 |
2011 |
|
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
In this paper, we review extant studies involving neurocognitive-genetic and neuroimaging-genetic perspectives and particularly related to catechol-O-methyltransferase (COMT), brain-derived neurotrophic factor (BDNF) and neuregulin-1 (NRG1) genes in SZ and BD.
|
21688113 |
2011 |
|
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
These studies suggest that DNA methylation analysis of MB-COMT promoter in saliva can potentially be used as an available epigenetic biomarker for disease state in SCZ and BD.
|
21820670 |
2011 |
|
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, we partially replicated our previous findings confirming a possible influence of COMT variants in MD and BD, particularly in early onset subjects, though not with the same risk genotypes.
|
21600957 |
2011 |
|
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Polymorphism rs165599 in the COMT gene was associated with susceptibility to bipolar disorder (BD), mainly in women (AG: OR = 1.46; GG: OR = 1.84; P = 0.03).
|
21595525 |
2011 |
|
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Association between catechol-O-methyltransferase Val(108/158)Met polymorphism and psychotic features of bipolar disorder.
|
20122740 |
2010 |