COMT, catechol-O-methyltransferase, 1312

N. diseases: 622; N. variants: 47
Disease: Fetal Growth Retardation ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.420 GeneticVariation phenotype BEFREE Intrauterine growth restriction was based on the birth weight ratio below 0.85; children were genotyped for polymorphisms associated with dopamine (DA) signaling, with the hypofunctional variants (TaqIA-A1 allele, DRD2-141C Ins/Ins, DRD4 7-repeat, DAT1-10-repeat, Met/Met-COMT) receiving the lowest scores, and a composite score was calculated reflecting the total number of the five genotypes. 29038017 2018
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.420 Biomarker phenotype CTD_human In conclusion, resveratrol increased uterine artery blood flow velocity and fetal weight in COMT⁻/⁻ mice, suggesting potential as a therapeutic strategy for PE and FGR. 23667712 2013
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.420 Biomarker phenotype BEFREE Our findings suggest that the allele encoding low-activity COMT may be a susceptible marker for intrauterine fetal growth restriction. 17047485 2006
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.420 Biomarker phenotype HPO