COMT, catechol-O-methyltransferase, 1312

N. diseases: 622; N. variants: 47
Disease: Panic Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.400 GeneticVariation disease BEFREE In this age- and gender-matched case-control study involving 119 PD patients and 119 healthy controls, we examined the genotype distributions and allele frequencies of the serotonin transporter gene linked polymorphic region (5-HTTLPR), -1019C/G (rs6295) promoter polymorphism of the serotonin receptor 1A (5-HT1A), and catechol-O-methyltransferase (COMT) gene polymorphism (rs4680) and their association with PD. 28096880 2017
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.400 GeneticVariation disease BEFREE rs4680 in COMT and rs3219151 in GABRA6 showed positive associations with PD and MDD. 25974322 2015
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.400 GeneticVariation disease BEFREE The gender-specific effect of the COMT genotype suggests that the COMT Val/Met genotype may influence a personality trait, openness to experience, in males with panic disorder. 24852514 2014
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.400 Biomarker disease BEFREE An interaction of BDNF × COMT × gender was confirmed in the PD group by MANCOVA on STAI scores and NEO-PI-R Neuroticism and Extraversion scores, whereas no association of such interactions was observed in the healthy controls. 24508446 2014
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.400 GeneticVariation disease BEFREE However, TBSS analysis showed increased fractional anisotropy (FA) in posterior thalamic radiation, posterior and superior corona radiata, superior longitudinal fasciculus, and sagittal stratum, all located in the right hemisphere in COMT AA/AG genotype group compared to GG genotype in panic disorder. 23141115 2013
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.400 GeneticVariation disease BEFREE A significant relationship was found between the COMT Val158Met polymorphism and PD. 22036916 2012
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.400 GeneticVariation disease BEFREE Only Val158Met polymorphism of the catechol-O-methyltransferase gene has been implicated in susceptibility to PD by several studies in independent samples and confirmed in a recent meta-analysis. 20048750 2010
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.400 GeneticVariation disease BEFREE Genetic variation at the catechol-O-methyltransferase (COMT) gene has been significantly associated with risk for various neuropsychiatric conditions such as schizophrenia, panic disorder, bipolar disorders, anorexia nervosa and others. 18574484 2010
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.400 Biomarker disease BEFREE We analyzed five genes, derived from pharmacological or translational mouse models, in a new case-control study of PD and SAD in European Americans: (1) the serotonin transporter (SLC6A4), (2) the serotonin receptor 1A, (3) catechol-O-methyltransferase, (4) a regulator of g-protein signaling and (5) the gastrin-releasing peptide receptor. 18663369 2010
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.400 GeneticVariation disease BEFREE Association between the catechol-O-methyltransferase Val158Met polymorphism and panic disorder: a replication. 20457471 2010
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.400 GeneticVariation disease BEFREE These results suggest that the COMT Met allele is related to the higher sympathetic nervous function observed in PD. 19900710 2010
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.400 GeneticVariation disease BEFREE The activation of [oxy-Hb] on the right lateral prefrontal cortex was observed in the Met/Met genotype of the COMT gene polymorphism of PD patient groups in the analysis of NIRS, which seems to be related to the autonomic dysfunction in the pathogenesis of PD. 19429001 2009
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.400 GeneticVariation disease LHGDN This COMT variant might increase the vulnerability to panic disorder by modulating dopaminergic tonus in relevant brain regions and thus altering neuronal processing of anxiety-related emotional cues. 18440204 2008
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.400 GeneticVariation disease BEFREE Nine gene-candidates, including 5-HTTLPR, MAO-A VNTR, TPH2 rs1386494, 5-HTR1A -1019C-G, 5-HTR2A 102T-C, CCKR1 246G-A, CCKR2 -215C-A, DRD1 -94G-A and COMT Val158Met, were selected for genotyping based on previous positive findings from genetic association studies in PD. 18832011 2008
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.400 GeneticVariation disease BEFREE This COMT variant might increase the vulnerability to panic disorder by modulating dopaminergic tonus in relevant brain regions and thus altering neuronal processing of anxiety-related emotional cues. 18440204 2008
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.400 GeneticVariation disease BEFREE However, given the relatively small number of case-control studies presently available, several more association studies, preferably including a larger number of family-based studies, are warranted for conclusive evaluation of the COMT val158met polymorphism as a vulnerability factor in panic disorder. 17357147 2007
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.400 GeneticVariation disease LHGDN However, given the relatively small number of case-control studies presently available, several more association studies, preferably including a larger number of family-based studies, are warranted for conclusive evaluation of the COMT val158met polymorphism as a vulnerability factor in panic disorder. 17357147 2007
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.400 AlteredExpression disease LHGDN Is 472G/A catechol-O-methyl-transferase gene polymorphism related to panic disorder? 17728665 2007
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.400 GeneticVariation disease LHGDN In the nuclear families, significant transmission disequilibrium for the valine allele was observed between the alleles of the Val158Met COMT polymorphism and panic disorder (p<0.01). 16525418 2006
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.400 AlteredExpression disease BEFREE Our results suggest that the COMT L/L genotype is associated with PD and the genetic variant of the COMT enzyme may be related to the clinical severity and treatment response to paroxetine in PD. 15203287 2004
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.400 GeneticVariation disease LHGDN In the present study, we genotyped a single nucleotide polymorphism (472G/A=V158M) in the coding region of the catechol-O-methyl-transferase (COMT) gene in 115 patients with panic disorder and age- and sex-matched controls. 15009906 2004
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.400 GeneticVariation disease BEFREE In the present study, we genotyped a single nucleotide polymorphism (472G/A=V158M) in the coding region of the catechol-O-methyl-transferase (COMT) gene in 115 patients with panic disorder and age- and sex-matched controls. 15009906 2004
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.400 GeneticVariation disease BEFREE Polymorphic markers at catechol O-methyltransferase (COMT), serotonin transporter (5-HTT), and tryptophan hydroxylase (TPH) genes were analyzed in a case-control association study of bipolar disorder patients with or without lifetime panic disorder. 11772685 2002
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.400 GeneticVariation disease BEFREE These results suggest that the L/L genotype of the COMT gene may be related to the development and treatment outcome of panic disorder in some patients. 12359690 2002
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.400 GeneticVariation disease BEFREE Our findings provide strong evidence for a susceptibility locus for panic disorder either within the COMT gene or in a nearby region of chromosome 22. 11950461 2002