COMT, catechol-O-methyltransferase, 1312

N. diseases: 622; N. variants: 47
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3160814
Disease: Cannabis use
Cannabis use
0.400 GeneticVariation disease BEFREE The analysis revealed significant differences between subjects COMT Val/Val homozygous and Met carriers with history of cannabis use, with a better performance on both tasks among the Met carriers group. 30790675 2019
CUI: C3160814
Disease: Cannabis use
Cannabis use
0.400 GeneticVariation disease BEFREE The interaction between cannabis use and the Val158Met polymorphism of the COMT gene in psychosis: A transdiagnostic meta - analysis. 29444152 2018
CUI: C3160814
Disease: Cannabis use
Cannabis use
0.400 GeneticVariation disease BEFREE The relationship between age at psychosis onset and COMT Val158Met and BDNF Val66Met polymorphisms with early cannabis use as well as those factors associated with early cannabis use were investigated. 28142064 2017
CUI: C3160814
Disease: Cannabis use
Cannabis use
0.400 GeneticVariation disease BEFREE Our results suggest that the COMT Val(158)Met polymorphism moderates the effect of regular cannabis use on severity of subclinical psychotic symptoms. 27052366 2016
CUI: C3160814
Disease: Cannabis use
Cannabis use
0.400 GeneticVariation disease BEFREE The relationship between catechol-O-methyltransferase gene Val158Met (COMT) polymorphism and premorbid cannabis use in Turkish male patients with schizophrenia. 25600541 2015
CUI: C3160814
Disease: Cannabis use
Cannabis use
0.400 Biomarker disease PSYGENET The relationship between catechol-O-methyltransferase gene Val158Met (COMT) polymorphism and premorbid cannabis use in Turkish male patients with schizophrenia. 25600541 2015
CUI: C3160814
Disease: Cannabis use
Cannabis use
0.400 GeneticVariation disease BEFREE This result suggests that COMT genotypes and cannabis use only influenced PE scores among individuals exposed to childhood abuse. 23445265 2014
CUI: C3160814
Disease: Cannabis use
Cannabis use
0.400 Biomarker disease PSYGENET We found that: (i) daily cannabis use is not associated with executive function deficits; and (ii) COMT val158met and 5-HTTLPR polymorphisms moderate the link between cannabis use and executive performance. 23449176 2013
CUI: C3160814
Disease: Cannabis use
Cannabis use
0.400 GeneticVariation disease BEFREE These findings suggest that a functional polymorphism in the COMT gene may moderate the interaction between childhood maltreatment and cannabis use on psychotic experiences in the general population. 23954148 2013
CUI: C3160814
Disease: Cannabis use
Cannabis use
0.400 GeneticVariation disease BEFREE We found that: (i) daily cannabis use is not associated with executive function deficits; and (ii) COMT val158met and 5-HTTLPR polymorphisms moderate the link between cannabis use and executive performance. 23449176 2013
CUI: C3160814
Disease: Cannabis use
Cannabis use
0.400 GeneticVariation disease BEFREE Cannabis use profiles and COMT Val158Met genotypes were obtained from 80 inpatients with schizophrenia-spectrum disorders and 77 inpatients with other non-psychotic disorders. 21231925 2011
CUI: C3160814
Disease: Cannabis use
Cannabis use
0.400 GeneticVariation disease BEFREE The results of our study are discussed in the context of previous findings, suggesting the involvement of COMT polymorphisms in the association between cannabis use and schizophrenia as well as the existence of additional factors mediating this association. 21310591 2011
CUI: C3160814
Disease: Cannabis use
Cannabis use
0.400 GeneticVariation disease BEFREE The aim of the study was to explore the existence of an interaction between COMT genotype and cannabis use in early stages of psychosis and its effects on the age of onset in a representative group of first-episode psychosis patients. 20493536 2010
CUI: C3160814
Disease: Cannabis use
Cannabis use
0.400 GeneticVariation disease BEFREE Logistic regression and generalized estimating equations' analyses were used to examine the role of adolescent-onset cannabis use (< or =15 years of age) on CIP risk, both controlling for previously implicated CIP risk factors and familial relationships, and considering potential interactions with COMT Val158Met genotype. 19944543 2010
CUI: C3160814
Disease: Cannabis use
Cannabis use
0.400 GeneticVariation disease BEFREE A functional polymorphism in the catechol-O-methyltransferase (COMT) gene moderated the influence of adolescent cannabis use on developing adult psychosis. 15866551 2005