|
Malignant neoplasm of stomach
|
0.660 |
GeneticVariation
|
disease |
BEFREE |
A small interfering RNA targeting the KLF6 splice variant, KLF6-SV1, as gene therapy for gastric cancer.
|
21538018 |
2011 |
|
Malignant neoplasm of stomach
|
0.660 |
Biomarker
|
disease |
HPO |
|
|
|
|
Malignant neoplasm of stomach
|
0.660 |
GeneticVariation
|
disease |
BEFREE |
The IVS1 -27G/A polymorphism of KLF6 has been investigated, which can influence susceptibility to gastric cancer and disease outcome.
|
18190240 |
2008 |
|
Malignant neoplasm of stomach
|
0.660 |
GeneticVariation
|
disease |
BEFREE |
Thus, in this Chinese population the KLF6 IVS1 -27AA genotype was associated with a decreased risk of gastric cancer and with cancer stage.
|
21309496 |
2011 |
|
Malignant neoplasm of stomach
|
0.660 |
AlteredExpression
|
disease |
BEFREE |
In summary, these data suggest that KLF6 gene is a direct target of miR-181a and miR-181a functions as an oncomir in gastric cancer by repressing the expression of tumor suppressor KLF6.
|
22581522 |
2012 |
|
Malignant neoplasm of stomach
|
0.660 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Malignant neoplasm of stomach
|
0.660 |
GeneticVariation
|
disease |
BEFREE |
To determine whether genetic alterations of KLF6 gene are involved in the development and/or progression of gastric cancer, we have screened a set of 80 sporadic gastric cancers for mutations and allele loss of the KLF6 gene.
|
15824733 |
2005 |
|
Malignant neoplasm of stomach
|
0.660 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Malignant neoplasm of stomach
|
0.660 |
AlteredExpression
|
disease |
BEFREE |
An inverse association was observed between miR‑18b and KLF6 mRNA levels in GC tissues.
|
30628682 |
2019 |
|
Malignant neoplasm of prostate
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
KLF6-SV1 overexpression accelerates human and mouse prostate cancer progression and metastasis.
|
18596922 |
2008 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This study investigated the prevalence and significance of KLF6 exon 2 mutations and splice variants (SVs) in different stages of human PC progression.
|
22819534 |
2012 |
|
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
Molecular profiling of prostatic acinar morphogenesis identifies PDCD4 and KLF6 as tissue architecture-specific prognostic markers in prostate cancer.
|
23219426 |
2013 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These findings indicate that significant genetic alterations of KLF6 occur in a minority of high-grade prostate cancers.
|
12651626 |
2003 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that KLF6 germ-line mutations are of marginal importance in prostate cancer predisposition in Finland.
|
15247715 |
2004 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Here we show that a germline KLF6 single nucleotide polymorphism, confirmed in a tri-institutional study of 3,411 men, is significantly associated with an increased relative risk of prostate cancer in men, regardless of family history of disease.
|
15735005 |
2005 |
|
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our study strongly supports the notion that KLF6 and TP53 mutations are not frequent events in prostate cancer.
|
19020536 |
2008 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recently, a candidate tumor suppressor gene, KLF6, which is mapped to chromosome 10p, was found to be frequently mutated in prostate cancer.
|
12740910 |
2003 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
It has been reported that the Krüppel-like transcription factor 6 (KLF6) gene is mutated in a proportion (15-55%) of human prostate cancers, and more recent data are emerging regarding mutated KLF6 in nasopharyngeal carcinomas, astrocytoid gliomas and colorectal cancer.
|
14503916 |
2003 |
|
Malignant neoplasm of prostate
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
PAC1-R null isoform expression in human prostate cancer tissue.
|
16372333 |
2006 |
|
Malignant neoplasm of prostate
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The Kruppel-like transcription factor KLF6 is a novel tumor-suppressor gene mutated in a significant fraction of human prostate cancer.
|
15064720 |
2004 |
|
Malignant neoplasm of prostate
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Krüppel-like factor 6 (KLF6) is a ubiquitously expressed zinc finger transcriptional factor, which has been suggested to be a candidate tumor suppressor gene in prostate cancer and astrocytic glioma.
|
15172991 |
2004 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The negative association between KLF6 IVS1-27A and prostate cancer risk supports a population-specific effect of susceptibility alleles in prostate tumorigenesis.
|
16598737 |
2006 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recently, high frequency (42%) of KLF6 mutations have been reported in colorectal cancers (CRC) as in prostate cancers, astrocytic gliomas and hepatocellular carcinomas.
|
16044160 |
2005 |
|
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our data suggest that KLF6 is a tumor suppressor gene involved in human prostate cancer.
|
11752579 |
2001 |