|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We investigated the role of LINC01234 in CRC development and confirmed its correlation with Krüppel-like factor 6 (KLF6), a tumor suppressor gene that is dysregulated in CRC.
|
31650732 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in renal carcinoma.
|
30858363 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition, KLF6 silencing attenuates ART-mediated inhibition of tumor growth in vivo.
|
31723124 |
2019 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Based on these findings a decrease or lack of the PAC1 receptor/PACAP signalling might have an influence on tumour growth and/or differentiation.
|
31788045 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Induction of FPN induces autophagy and activates the transcription factors tumor protein 53 (p53) and Kruppel-like factor 6 (KLF6) and their common downstream target, cyclin-dependent kinase inhibitor 1A (p21).
|
29061069 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
By employing bioinformatics analysis, point mutation and luciferase reporter assays, we further identified the 3'-UTR of tumor suppressor Krüppel-like factor 6 (KLF6) as the direct target of miR-342-3p.
|
30638935 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Regarding its role in tumorigenesis, KLF6 is considered a tumor suppressor.
|
31824948 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
miR-181a is up-regulated in ccRCC and may act as a tumor promoting factor by targeting KLF6 expression.
|
29066014 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
When given to mice bearing subcutaneous or orthotopic xenograft, PAC-1 and WF-210 inhibited the tumor growth and tumor angiogenesis.
|
29269017 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The wtKLF6 was significantly downexpressed in tumors compared to normal tissues (<i>p</i> = 0.0015), whereas KLF6-SV1 and KLF6-SV2 were overexpressed in tumors compared to wtKLF6 and KLF6-SV3 (<i>p</i> < 0.0001).
|
29854578 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
RNA Silencing was used for wtKLF6 and KLF6-SV1.Tumor cell apoptosis was measured.
|
29432497 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The cellular effects of miR-142-5p were mediated by the modulation of tumour suppressor KLF6 expression, as the expression of miR-142-5p and KLF6 protein are inversely correlated in colon cancer cells.
|
29337244 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
KLF6-SV2 plays a role as tumor suppressor by efficiently blocking cell proliferation, arresting cell cycle and inducing apoptosis in colorectal cancer, which may be related to increased expression of p21 and Bax.
|
29084019 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Moreover, bioinformatics and luciferase reporter gene assays confirmed that miR-4262 targeted the mRNA 3'-UTR region of KLF6 and KLF15, two characterized tumor suppressor genes. miR-4262 suppressed protein levels of KLF6 and KLF15 in MDA-MB-231 cells, and the suppression could be rescued by the transfection of pcDNA-KLF6 and -KLF15.
|
27629257 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The transcription factor forkhead box O1 (FOXO1) negatively regulates activated EGFR signaling by turning on the gene expression of tumor suppressor Kruppel-like factor 6.
|
27966721 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In a mouse xenograft model of human ccRCC, silencing KLF6 increased tumor cell proliferation and malignant character, whereas E2F1 silencing reversed these properties.
|
27780824 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our study is the first to provide demonstrate that KLF6 functions as a tumor suppressor gene and prevents the metastasis of oral cancer cells.
|
28638268 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Both IL-2 vectors exerted significant tumor growth delay; however, attempts to further enhance antitumor activity of the IL-2 vectors by combining with the proapoptotic drug procaspase activating compound 1 (PAC1) were unsuccessful.
|
27151235 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Therefore, our findings show that KLF6 suppresses growth and invasion of HCC cells in vitro and in vivo, suggesting a tumor suppressive function in HCC and provides the potential therapeutic target for the treatment of HCC.
|
27510817 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Concordantly, single-copy deletion of Klf6 in a HCC mouse model results in increased tumor formation, increased metastasis to the lungs and decreased survival, indicating that KLF6 suppresses both HCC development and metastasis.
|
26876204 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, nude mice carrying the tumors of overexpressed miR-101 combined with knockdown of KLF6 produced the smallest tumors and showed the highest survival rate.
|
25230316 |
2015 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We report 2 unusual cytogenetic findings in a pediatric Ewing sarcoma, an insertion of the MIC2 gene encoding CD99 from Xp to 10p and a submicroscopic deletion of the well-known tumor supressor gene KLF6.
|
24322504 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Reduced KLF6 expression was observed in 41 (83.67 %) of the 49 breast cancer tumors.
|
24519062 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
To sum up, our findings unveiled a novel molecular mechanism that specific miRNAs promoted tumorigenesis by targeting the tumor suppressive isoform KLF6-FL rather than its oncogenic isoform KLF6-SV1.
|
24921656 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Kruppel-like factor 6 (KLF6) is a tumor suppressor gene frequently downregulated in a number of human cancers, including osteosarcoma.
|
23322324 |
2013 |