Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
<i>In vitro</i> and preclinical <i>in vivo</i> data show that administration of ADM exerts anti-inflammatory, antimicrobial, and protective effects on endothelial barrier function during sepsis, but other work suggests that it may also decrease blood pressure, which could be detrimental for patients with septic shock.
|
29520277 |
2018 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Adrenomedullin (ADM) is a potent hypotensive peptide produced by macrophages and endothelial cells during ischemia and sepsis.
|
15930287 |
2005 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Adrenomedullin increased with severity (sepsis: 25.8 pg/mL [IQR 20.3-40.2], severe sepsis: 84.2 pg/mL [IQR 42.7-118.5], septic shock: 119.7 pg/mL [IQR 83.8-172.6]; P<.0001).
|
27865148 |
2017 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Adrenomedullin (ADM) is an important regulator of endothelial barrier function and vascular tone, and may represent a novel treatment target in sepsis.
|
29856470 |
2018 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
ADM is strongly elevated in patients with sepsis and in patients with acute heart failure.
|
30592365 |
2019 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Adrenomedullin (ADM) is a vasoactive peptide in sepsis.
|
30822437 |
2019 |
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Adrenomedullin has vascular properties and elevated plasma adrenomedullin levels were detected in sepsis.
|
31625979 |
2020 |
Sepsis
|
0.600 |
AlteredExpression
|
disease |
LHGDN |
Adrenomedullin and adrenomedullin binding protein-1: their role in the septic response.
|
12643861 |
2003 |
Sepsis
|
0.600 |
Biomarker
|
disease |
LHGDN |
Adrenomedullin and endothelial barrier function.
|
18000597 |
2007 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Circulating Biologically Active Adrenomedullin Predicts Organ Failure and Mortality in Sepsis.
|
31037864 |
2019 |
Sepsis
|
0.600 |
AlteredExpression
|
disease |
LHGDN |
Circulating precursor levels of endothelin-1 and adrenomedullin, two endothelium-derived, counteracting substances, in sepsis.
|
18080871 |
2008 |
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Compared to those of healthy individuals (n = 47), mRNA levels of ANG2, IL10, HBP, PCT, and ADM were increased in patients who eventually developed sepsis.
|
29413717 |
2018 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Finally, effects of single and repeated dose administration of HAM1101, HAM8101 and placebo on survival were assessed in CLP-induced murine sepsis (n = 60, n = 10 per group).
|
29324627 |
2018 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
High plasma concentrations of ADM correlate with worse outcome in sepsis patients.
|
30782906 |
2019 |
Sepsis
|
0.600 |
Biomarker
|
disease |
RGD |
Human adrenomedullin and its binding protein ameliorate sepsis-induced organ injury and mortality in jaundiced rats.
|
20132852 |
2010 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
In the present prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock 1 (, AdrenOSS-1) study, we assessed relationships between circulating bio-ADM during the initial intensive care unit (ICU) stay and short-term outcome in order to eventually design a biomarker-guided randomized controlled trial.
|
30583748 |
2018 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this review, we first provide a brief overview of the currently available data on the role of adrenomedullin in sepsis and describe its effects on endothelial barrier function and vasodilation.
|
29324626 |
2018 |
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
It is revealed that the distributions of receptor or binding sites of AM are changed in sepsis, and it is suggested that AM plays distinct roles in the clinical course of this syndrome.
|
10777702 |
2000 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
It remains unknown whether a combination of human AM and human AMBP-1 (AM/AMBP-1) is also beneficial in sepsis and, if so, whether human AM/AMBP-1 reverses established sepsis in rats.
|
19009024 |
2009 |
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Plasma levels of mid-regional pro-adrenomedullin in sepsis are associated with risk of death.
|
30207133 |
2019 |
Sepsis
|
0.600 |
AlteredExpression
|
disease |
LHGDN |
Receptor activity-modifying proteins: RAMPing up adrenomedullin signaling.
|
17053041 |
2007 |
Sepsis
|
0.600 |
Biomarker
|
disease |
CTD_human |
Role of cyclooxygenase in ventricular effects of adrenomedullin: is adrenomedullin a double-edged sword in sepsis?
|
14766677 |
2004 |
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Specifically, we find that certain conditions, such as pregnancy, cardiovascular disease, and sepsis, are associated with robust and dynamic changes in the expression of AM and AM receptor proteins, which together represent an elegant mechanism for altering the physiological responsiveness or function of AM.
|
17053041 |
2007 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Strong evidence now exists that AM is able to act as an autocrine, paracrine, or endocrine mediator in a number of biologically significant functions, including the endothelial regulation of blood pressure, protection against organ damage in sepsis or hypoxia, and the control of blood volume through the regulation of thirst.
|
15464589 |
2004 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
The biological role of adrenomedullin (ADM), a hormone involved in hemodynamic homeostasis, is controversial in sepsis because administration of either the peptide or an antibody against it may be beneficial.
|
28411114 |
2017 |