ADM, adrenomedullin, 133

N. diseases: 405; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 AlteredExpression disease BEFREE Adrenomedullin has vascular properties and elevated plasma adrenomedullin levels were detected in sepsis. 31625979 2020
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 AlteredExpression disease BEFREE Plasma levels of mid-regional pro-adrenomedullin in sepsis are associated with risk of death. 30207133 2019
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE ADM is strongly elevated in patients with sepsis and in patients with acute heart failure. 30592365 2019
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Adrenomedullin (ADM) is a vasoactive peptide in sepsis. 30822437 2019
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE High plasma concentrations of ADM correlate with worse outcome in sepsis patients. 30782906 2019
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Circulating Biologically Active Adrenomedullin Predicts Organ Failure and Mortality in Sepsis. 31037864 2019
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE In the present prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock 1 (, AdrenOSS-1) study, we assessed relationships between circulating bio-ADM during the initial intensive care unit (ICU) stay and short-term outcome in order to eventually design a biomarker-guided randomized controlled trial. 30583748 2018
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE The overall diagnostic accuracy of ADM and proADM in application to sepsis was pooled according to a bivariate model. 29246418 2018
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE <i>In vitro</i> and preclinical <i>in vivo</i> data show that administration of ADM exerts anti-inflammatory, antimicrobial, and protective effects on endothelial barrier function during sepsis, but other work suggests that it may also decrease blood pressure, which could be detrimental for patients with septic shock. 29520277 2018
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Adrenomedullin (ADM) is an important regulator of endothelial barrier function and vascular tone, and may represent a novel treatment target in sepsis. 29856470 2018
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 AlteredExpression disease BEFREE Compared to those of healthy individuals (n = 47), mRNA levels of ANG2, IL10, HBP, PCT, and ADM were increased in patients who eventually developed sepsis. 29413717 2018
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Usefulness of midregional pro-adrenomedullin as a marker of organ damage and predictor of mortality in patients with sepsis. 29246637 2018
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Finally, effects of single and repeated dose administration of HAM1101, HAM8101 and placebo on survival were assessed in CLP-induced murine sepsis (n = 60, n = 10 per group). 29324627 2018
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE In this review, we first provide a brief overview of the currently available data on the role of adrenomedullin in sepsis and describe its effects on endothelial barrier function and vasodilation. 29324626 2018
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE The biological role of adrenomedullin (ADM), a hormone involved in hemodynamic homeostasis, is controversial in sepsis because administration of either the peptide or an antibody against it may be beneficial. 28411114 2017
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Adrenomedullin increased with severity (sepsis: 25.8 pg/mL [IQR 20.3-40.2], severe sepsis: 84.2 pg/mL [IQR 42.7-118.5], septic shock: 119.7 pg/mL [IQR 83.8-172.6]; P<.0001). 27865148 2017
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE It remains unknown whether a combination of human AM and human AMBP-1 (AM/AMBP-1) is also beneficial in sepsis and, if so, whether human AM/AMBP-1 reverses established sepsis in rats. 19009024 2009
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 AlteredExpression disease BEFREE Specifically, we find that certain conditions, such as pregnancy, cardiovascular disease, and sepsis, are associated with robust and dynamic changes in the expression of AM and AM receptor proteins, which together represent an elegant mechanism for altering the physiological responsiveness or function of AM. 17053041 2007
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Adrenomedullin (ADM) is a potent hypotensive peptide produced by macrophages and endothelial cells during ischemia and sepsis. 15930287 2005
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Strong evidence now exists that AM is able to act as an autocrine, paracrine, or endocrine mediator in a number of biologically significant functions, including the endothelial regulation of blood pressure, protection against organ damage in sepsis or hypoxia, and the control of blood volume through the regulation of thirst. 15464589 2004
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease CTD_human Role of cyclooxygenase in ventricular effects of adrenomedullin: is adrenomedullin a double-edged sword in sepsis? 14766677 2004
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Thus, modulation of vascular responsiveness to AM by AMBP-1 may provide a novel approach for the management of sepsis. 12643861 2003
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 AlteredExpression disease BEFREE It is revealed that the distributions of receptor or binding sites of AM are changed in sepsis, and it is suggested that AM plays distinct roles in the clinical course of this syndrome. 10777702 2000