Iron Overload
|
0.400 |
Biomarker
|
disease |
BEFREE |
These data suggest that the reported role of ceruloplasmin cannot fully explain the iron hepatosplenic phenotype in HA, encouraging the search for additional mechanisms.-Kenawi, M., Rouger, E., Island, M.-L., Leroyer, P., Robin, F., Remy, S., Tesson, L., Anegon, I., Nay, K., Derbré, F., Brissot, P., Ropert, M., Cavey, T., Loréal, O. Ceruloplasmin deficiency does not induce macrophagic iron overload: lessons from a new rat model of hereditary aceruloplasminemia.
|
31560858 |
2019 |
Iron Overload
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, we found increased levels of iron, transferrin, and ceruloplasmin in microglial cells, indicating an attempt by the immune system to remove the excess iron.
|
28233916 |
2017 |
Iron Overload
|
0.400 |
Biomarker
|
disease |
CTD_human |
Hepatic but not brain iron is rapidly chelated by deferasirox in aceruloplasminemia due to a novel gene mutation.
|
20801540 |
2010 |
Iron Overload
|
0.400 |
Biomarker
|
disease |
BEFREE |
Glutathione synthesis inhibitor butathione sulfoximine regulates ceruloplasmin by dual but opposite mechanism: Implication in hepatic iron overload.
|
20211720 |
2010 |
Iron Overload
|
0.400 |
Biomarker
|
disease |
BEFREE |
Ceruloplasmin (Cp), a copper-containing protein, plays a significant role in body iron homeostasis as aceruloplasminemia patients and Cp knock-out mice exhibit iron overload in several tissues including liver and brain.
|
19019832 |
2009 |
Iron Overload
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Here, we report the identification, clinical characterization, and in silico analysis of a novel compound heterozygosity in the ceruloplasmin gene of a 31-year-old man with iron overload.
|
17710675 |
2007 |
Iron Overload
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The absence of ceruloplasmin and its ferroxidase activity leads to pathological iron overload in the brain and other organs.
|
17307325 |
2007 |
Iron Overload
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Hepatic iron overload associated with a decreased serum ceruloplasmin level in a novel clinical type of aceruloplasminemia.
|
16831606 |
2006 |
Iron Overload
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Hereditary hyperferritinemias are linked to mutations of three genes: the L-ferritin gene responsible for the hereditary hyperferritinemia cataract syndrome (without iron overload), the ferroportin gene leading to a dominant form of iron overload, and the ceruloplasmin (CP) gene corresponding to an iron overload syndrome with neurological symptoms.
|
15842597 |
2005 |
Iron Overload
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Aceruloplasminemia is an autosomal recessive disease of iron overload associated with mutation(s) in the ceruloplasmin gene.
|
12044538 |
2002 |
Iron Overload
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Anemia and iron overload due to compound heterozygosity for novel ceruloplasmin mutations.
|
12200392 |
2002 |
Iron Overload
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our inability to resolve the patient's iron overload by regular phlebotomy is consistent with recent animal studies indicating an essential role for ceruloplasmin in cellular iron efflux.
|
11076887 |
2000 |
Iron Overload
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A role of the copper protein ceruloplasmin (Cp) in iron metabolism is suggested by its ferroxidase activity and by the tissue iron overload in hereditary Cp deficiency patients.
|
10777486 |
2000 |