CPB2, carboxypeptidase B2, 1361

N. diseases: 148; N. variants: 11
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity
0.300 Biomarker disease CTD_human Hemostatic abnormalities including TAFI alterations represent a link between obesity and vascular thrombosis. 16959692 2006
CUI: C0002453
Disease: Amenorrhea
Amenorrhea
0.300 Biomarker phenotype CTD_human A significant correlation was found between baseline TAFI antigen concentrations and the duration of amenorrhea (P < 0.05; r = 0.33). 16167916 2005
CUI: C0032796
Disease: Postpartum Amenorrhea
Postpartum Amenorrhea
0.300 Biomarker phenotype CTD_human The effects of short-term raloxifene therapy on fibrinolysis markers: TAFI, tPA, and PAI-1. 16167916 2005
Experimental Autoimmune Encephalomyelitis
0.200 Biomarker disease RGD Minocycline effects on the cerebrospinal fluid proteome of experimental autoimmune encephalomyelitis rats. 22768796 2012
CUI: C0026766
Disease: Multiple Organ Failure
Multiple Organ Failure
0.200 Biomarker phenotype RGD EF6265, a novel inhibitor of activated thrombin-activatable fibrinolysis inhibitor, protects against sepsis-induced organ dysfunction in rats. 19325462 2009
Chemical and Drug Induced Liver Injury
0.200 Biomarker disease RGD A novel function of thrombin-activatable fibrinolysis inhibitor during rat liver regeneration and in growth-promoted hepatocytes in primary culture. 19386599 2009
CUI: C0004610
Disease: Bacteremia
Bacteremia
0.200 Biomarker disease RGD Plasma thrombin activatable fibrinolysis inhibitor and tissue factor pathway inhibitor changes following sepsis. 17911187 2007
CUI: C0243026
Disease: Sepsis
Sepsis
0.200 Biomarker disease RGD Tissue factor pathway inhibitor and thrombin activatable fibrinolytic inhibitor plasma levels following burn and septic injuries in rats. 15497025 2004
CUI: C2985280
Disease: Blood Protein Measurement
Blood Protein Measurement
0.100 GeneticVariation phenotype GWASCAT Genomic atlas of the human plasma proteome. 29875488 2018
CUI: C2985280
Disease: Blood Protein Measurement
Blood Protein Measurement
0.100 GeneticVariation phenotype GWASCAT Co-regulatory networks of human serum proteins link genetics to disease. 30072576 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.060 Biomarker group BEFREE Procarboxypeptidase U (proCPU, TAFI, proCPB2) in cerebrospinal fluid during ischemic stroke is associated with stroke progression, outcome and blood-brain barrier dysfunction. 29194929 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.060 AlteredExpression group BEFREE The dose-response curve showed that, as a whole, with the increase of TAFI levels, the relative risk of stroke first increased and then decreased (p=0.0127). 28890533 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.060 GeneticVariation group BEFREE Thrombin activatable fibrinolysis inhibitor gene polymorphisms are associated with antigenic levels in the Asian-Indian population but may not be a risk for stroke. 18986391 2008
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.060 Biomarker group BEFREE AP showed associations with all 4 major subtypes of ischemic stroke and intact TAFI to large vessel disease and cryptogenic stroke. 17272741 2007
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.060 AlteredExpression group LHGDN AP showed associations with all 4 major subtypes of ischemic stroke and intact TAFI to large vessel disease and cryptogenic stroke. 17272741 2007
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.060 AlteredExpression group LHGDN Thrombin activatable fibrinolysis inhibitor and its relationship to fibrinolysis and inflammation during the acute and convalescent phase of ischemic stroke. 17473579 2007
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.060 AlteredExpression group BEFREE This indicates that increased functional TAFI levels after stroke are not caused by an acute phase reaction. 16092924 2005
CUI: C0398623
Disease: Thrombophilia
Thrombophilia
0.050 Biomarker disease BEFREE The authors discuss the similarities and differences between TIC and MAC, and propose a mechanism for the hypercoagulable state of MAC that revolves around the thrombomodulin-thrombin complex as it switches between activating the protein C anticoagulation pathway or the thrombin activatable fibrinolysis inhibitor coagulation pathway. 31108555 2019
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.050 Biomarker disease BEFREE Procarboxypeptidase U (proCPU, TAFI, proCPB2) in cerebrospinal fluid during ischemic stroke is associated with stroke progression, outcome and blood-brain barrier dysfunction. 29194929 2018
CUI: C0398623
Disease: Thrombophilia
Thrombophilia
0.050 AlteredExpression disease BEFREE TAFI serves as a link between two limbs of hemostasis, with its higher levels promoting inhibition of fibrinolytic system and thus promoting a hypercoagulable state. 27487812 2017
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.050 AlteredExpression disease BEFREE Similarly, in general, with the increase of TAFI levels, the curve showed that the relative risk of ischemic stroke first increased and then decreased (p=0.0110). 28890533 2017
CUI: C0398623
Disease: Thrombophilia
Thrombophilia
0.050 AlteredExpression disease BEFREE High level of TAFI antigen in attack-free period of FMF disease shows ongoing subclinical inflammation and hypercoagulability. 24580410 2014
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.050 GeneticVariation disease BEFREE High functional CPB2 levels have been found to be associated with an increased risk for ischemic stroke. 18986391 2008
CUI: C0398623
Disease: Thrombophilia
Thrombophilia
0.050 Biomarker disease BEFREE Thrombin-activatable fibrinolysis inhibitor (TAFI) may contribute to a hypercoagulable state, and therefore we were interested in the role of TAFI in SVT. 17264944 2007
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.050 Biomarker disease BEFREE AP showed associations with all 4 major subtypes of ischemic stroke and intact TAFI to large vessel disease and cryptogenic stroke. 17272741 2007