Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE Author Correction: Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition. 30087441 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.400 AlteredExpression disease BEFREE Taken together, our results suggest that methylation changes of Klf14 in those tissues may be associated with changes in gene expression and inflammation on the adipose tissue of obesity and T2D. 29425818 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE We show that carriers of the KLF14 T2D risk allele shift body fat from gynoid stores to abdominal stores and display a marked increase in adipocyte cell size, and that these effects on fat distribution, and the T2D association, are female specific. 29632379 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.400 AlteredExpression disease BEFREE We discuss a recent study that has identified and validated the link between a type-2 diabetes (T2D) association and human adipose biology by means of KLF14 gene expression. 29880058 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease CTD_human We show that carriers of the KLF14 T2D risk allele shift body fat from gynoid stores to abdominal stores and display a marked increase in adipocyte cell size, and that these effects on fat distribution, and the T2D association, are female specific. 29632379 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE From the molecular function aspect, this review focuses on the impact of KLF14-mediated regulation in major atherosclerosis-related diseases and pathological processes, such as insulin resistance, type 2 diabetes, dyslipidemia, inflammation, obesity, metabolic syndrome, cell proliferation and differentiation. 28641818 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE The transcription factor Krüppel-like factor 14 (KLF14) has been associated with type 2 diabetes and high-density lipoprotein-cholesterol (HDL-C) through genome-wide association studies. 28962896 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE Despite strong evidence showing that a polymorphism in the <i>Klf14</i> gene is closely linked to the development of type 2 diabetes, the physiological and metabolic functions of KLF14 still remain unclear. 29123026 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE Genome-wide association studies have shown that Krüppel-like factor 14 (KLF14) is associated with both Type 2 diabetes mellitus and lipid metabolism. 27923151 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE Polymorphisms in Four Genes (KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963) and Their Correlation with Type 2 Diabetes Mellitus in Han Chinese in Henan Province, China. 26927145 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE However, since HNF4A and KLF14 are established loci for type 2 diabetes, it is unlikely that HDL-C solely mediates these associations. 26670163 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE The T2D risk alleles of rs972283 near KLF14 and rs11634397 near ZFAND6 were associated with a higher risk for elevated triglycerides (rs972283: 1.11 (1.02, 1.24), P = 1.46 × 10-2; rs11634397: 1.14 (1.00, 1.29), P = 4.66 × 10-2), while the T2D risk alleles of rs780094 in GCKR and rs7903146 in TCF7L2 were related to a lower risk of elevated triglycerides (rs780094: 0.86 (0.80, 0.93), P = 1.35 × 10-4; rs7903146: 0.82 (0.69, 0.98), P = 3.18 × 10-2). 26599349 2015
Diabetes Mellitus, Non-Insulin-Dependent
0.400 AlteredExpression disease BEFREE KLF14 mRNA and protein in fat and muscle were significantly decreased in HFD-fed mice, db/db mice and T2DM patients. 26226221 2015
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE We performed an meta-analysis to assess the contributions of rs151290 in KCNQ1 and rs972283 in KLF14 to risk of T2DM. 24486580 2014
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE This study confirms parent-of-origin effects in the association with type 2 diabetes for variants in KLF14, MOB2, and KCNQ1. 23630301 2013
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE Our results revealed that seven index SNPs at the TCF7L2, KLF14, KCNQ1, ADCY5, CDKAL1, JAZF1, and GCKR loci were significantly associated with T2D (P < 0.05). 23193183 2013
Diabetes Mellitus, Non-Insulin-Dependent
0.400 AlteredExpression disease BEFREE Here we show that the type 2 diabetes and high-density lipoprotein cholesterol-associated cis-acting expression quantitative trait locus (eQTL) of the maternally expressed transcription factor KLF14 acts as a master trans regulator of adipose gene expression. 21572415 2011
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE The meta-analysis revealed that rs2943641 in the IRS1 locus was significantly associated with type 2 diabetes, (P = 0.0034, OR = 1.15 95% confidence interval; 1.05-1.26) and 3 SNPs, rs10930963 in the MTNR1B locus, rs972283 in the KLF14 locus, and rs231362 in the KCNQ1 locus, had nominal association with type 2 diabetes in the present Japanese samples (P<0.05). 22046406 2011
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE We have demonstrated that 13 variants confer an increased risk of type 2 diabetes in our Pakistani populations; to our knowledge this is the first time that SNPs in or near KCNQ1, JAZF1, IRS1, KLF14, CHCHD9 and DUSP9 have been significantly associated with the disease in South Asians. 21350842 2011