|
Prostatic Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Identification of genes potentially involved in the acquisition of androgen-independent and metastatic tumor growth in an autochthonous genetically engineered mouse prostate cancer model.
|
17013881 |
2007 |
|
Malignant neoplasm of prostate
|
0.300 |
Biomarker
|
disease |
CTD_human |
Identification of genes potentially involved in the acquisition of androgen-independent and metastatic tumor growth in an autochthonous genetically engineered mouse prostate cancer model.
|
17013881 |
2007 |
|
Hepatitis E
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hepatitis E virus (HEV) is a 7.2-kb positive-sense, single-stranded RNA virus containing three partially overlapping reading frames, ORF1 to ORF3.
|
31019049 |
2019 |
|
Waist-Hip Ratio
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Hepatitis E
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hepatitis E Virus Genotype 3 Genomes from RNA-Positive but Serologically Negative Plasma Donors Have CUG as the Start Codon for ORF3.
|
30278453 |
2018 |
|
Hepatitis E
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, special attention is focused on quasi-enveloped HEV virions and the potential role of the HEV-ORF3 product as antibody-neutralization target on the surface of quasi-enveloped HEV virions to provide new insights for the future development of improved vaccines against zoonotic HEV infection.
|
29520257 |
2018 |
|
Hepatitis E
|
0.100 |
Biomarker
|
disease |
BEFREE |
Palmitoylation mediates membrane association of hepatitis E virus ORF3 protein and is required for infectious particle secretion.
|
30532200 |
2018 |
|
Coronary Artery Disease
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.
|
29212778 |
2018 |
|
Hepatitis E
|
0.100 |
Biomarker
|
disease |
BEFREE |
ORF3 as a sensitive and specific diagnostic index for hepatitis E.
|
28587339 |
2017 |
|
Hepatitis E
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hepatitis E virus ORF3 is a functional ion channel required for release of infectious particles.
|
28096411 |
2017 |
|
Hepatitis E
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fecal samples were collected from 170 pigs and screened for hepatitis E virus RNA using a duplex real-time RT-PCR targeting a highly conserved 70nt long sequence within overlapping parts of ORF2 and ORF3 as well as a 113nt sequence of ORF2.
|
28089613 |
2017 |
|
Hepatitis E
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, recombinant CaHEV truncated ORF2 and complete ORF3 proteins were evaluated separately for immunoprotection of chickens against CaHEV infection.
|
28528763 |
2017 |
|
Hepatitis E
|
0.100 |
Biomarker
|
disease |
BEFREE |
The ORF3 Protein of Genotype 1 Hepatitis E Virus Suppresses TLR3-induced NF-κB Signaling via TRADD and RIP1.
|
27270888 |
2016 |
|
Adenocarcinoma Of Esophagus
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association studies in oesophageal adenocarcinoma and Barrett's oesophagus: a large-scale meta-analysis.
|
27527254 |
2016 |
|
Hepatitis E
|
0.100 |
Biomarker
|
disease |
BEFREE |
Replacement of the hepatitis E virus ORF3 protein PxxP motif with heterologous late domain motifs affects virus release via interaction with TSG101.
|
26457367 |
2015 |
|
Hepatitis E
|
0.100 |
Biomarker
|
disease |
BEFREE |
Identification of miR-221 and -222 as important regulators in genotype IV swine hepatitis E virus ORF3-expressing HEK 293 cells.
|
23579640 |
2013 |
|
Hepatitis E
|
0.100 |
Biomarker
|
disease |
BEFREE |
Consideration of the clinical manifestations of hepatitis E reported previously and the results of biological analysis from this study suggests that the ORF3 protein is likely to lead to an imbalance of coagulation and fibrinolysis by interacting with host proteins and triggering the corresponding pathological processes.
|
23418552 |
2013 |
|
Hepatitis E
|
0.100 |
Biomarker
|
disease |
BEFREE |
The PSAP motif within the ORF3 protein of an avian strain of the hepatitis E virus is not critical for viral infectivity in vivo but plays a role in virus release.
|
22438540 |
2012 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
|
21378990 |
2011 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
|
21378990 |
2011 |
|
Hepatitis E
|
0.100 |
Biomarker
|
disease |
BEFREE |
Varying abilities of recombinant polypeptides from different regions of hepatitis E virus ORF2 and ORF3 to detect anti-HEV immunoglobulin M.
|
19382255 |
2009 |
|
Hepatitis E
|
0.100 |
Biomarker
|
disease |
BEFREE |
T-cell epitope mapping of ORF2 and ORF3 proteins of human hepatitis E virus.
|
17381721 |
2007 |
|
Hepatitis E
|
0.100 |
Biomarker
|
disease |
BEFREE |
ORF3 protein of hepatitis E virus is not required for replication, virion assembly, or infection of hepatoma cells in vitro.
|
16928762 |
2006 |
|
Hepatitis E
|
0.100 |
Biomarker
|
disease |
BEFREE |
An earlier study in our laboratory has demonstrated that the ORF3 protein of the hepatitis E virus expedites the secretion of alpha1 microglobulin, an immunosuppressant molecule.
|
16407257 |
2006 |
|
Hepatitis E
|
0.100 |
Biomarker
|
disease |
BEFREE |
Non-isotopic in situ hybridization (digoxigenin-labeled probe directed towards hepatitis E virus ORF1) and immunohistochemistry (against hepatitis E virus ORF2 and ORF3) were applied to detect hepatitis E virus genome and gene product in the liver tissue of two patients with fulminant hepatitis E seropositive for hepatitis E virus RNA.
|
7560853 |
1995 |