Lupus Erythematosus, Systemic
|
0.690 |
GeneticVariation
|
disease |
BEFREE |
CR2 genetic variants are associated with susceptibility to systemic lupus erythematosus as well as to HIV-1 infection.
|
31634193 |
2020 |
Lupus Erythematosus, Systemic
|
0.690 |
Biomarker
|
disease |
BEFREE |
With this novel tool, we show that disruption of the critical C3d-CR2 ligand-receptor binding step alone substantially ameliorates autoimmunity and renal disease in the MRL/<i>lpr</i> model of SLE.
|
31732528 |
2019 |
Lupus Erythematosus, Systemic
|
0.690 |
AlteredExpression
|
disease |
BEFREE |
In agreement with CD19 controlling TLR9 responses in B cells, decreased expression of the CD19/CD21 complex on SLE B cells was detected as early as the transitional B cell stage.
|
29515028 |
2018 |
Lupus Erythematosus, Systemic
|
0.690 |
GeneticVariation
|
disease |
BEFREE |
We previously identified variants in complement receptor 2 (CR2/CD21) that were associated with decreased risk of SLE.
|
25180293 |
2016 |
Lupus Erythematosus, Systemic
|
0.690 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether CR2 gene polymorphisms are associated with risk of ONFH in SLE patients.
|
27446959 |
2016 |
Lupus Erythematosus, Systemic
|
0.690 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
CD21 and CD19 deficiency: Two defects in the same complex leading to different disease modalities.
|
26325596 |
2015 |
Lupus Erythematosus, Systemic
|
0.690 |
GeneticVariation
|
disease |
BEFREE |
These data confirm the effects of rs3813946 on CR2 transcription, identifying the 5' UTR to be a novel regulatory element for the CR2 gene in which variation may alter gene function and modify the development of lupus.
|
22673213 |
2012 |
Lupus Erythematosus, Systemic
|
0.690 |
SusceptibilityMutation
|
disease |
ORPHANET |
These data confirm the effects of rs3813946 on CR2 transcription, identifying the 5' UTR to be a novel regulatory element for the CR2 gene in which variation may alter gene function and modify the development of lupus.
|
22673213 |
2012 |
Lupus Erythematosus, Systemic
|
0.690 |
GeneticVariation
|
disease |
BEFREE |
A recent family-based analysis in Caucasian and Chinese populations provided evidence for association of single-nucleotide polymorphisms (SNPs) in the complement receptor 2 (CR2/CD21) gene with SLE.
|
19387458 |
2009 |
Lupus Erythematosus, Systemic
|
0.690 |
Biomarker
|
disease |
LHGDN |
Single-nucleotide polymorphism 1 (rs3813946), located in the 5' untranslated region of the CR2 gene, altered transcriptional activity, suggesting a potential mechanism by which CR2 could contribute to the development of lupus.
|
17360460 |
2007 |
Lupus Erythematosus, Systemic
|
0.690 |
GeneticVariation
|
disease |
BEFREE |
Single-nucleotide polymorphism 1 (rs3813946), located in the 5' untranslated region of the CR2 gene, altered transcriptional activity, suggesting a potential mechanism by which CR2 could contribute to the development of lupus.
|
17360460 |
2007 |
Lupus Erythematosus, Systemic
|
0.690 |
SusceptibilityMutation
|
disease |
ORPHANET |
Single-nucleotide polymorphism 1 (rs3813946), located in the 5' untranslated region of the CR2 gene, altered transcriptional activity, suggesting a potential mechanism by which CR2 could contribute to the development of lupus.
|
17360460 |
2007 |
Lupus Erythematosus, Systemic
|
0.690 |
Biomarker
|
disease |
BEFREE |
Characterization of human complement receptor type 2 (CR2/CD21) as a receptor for IFN-alpha: a potential role in systemic lupus erythematosus.
|
16785534 |
2006 |
Lupus Erythematosus, Systemic
|
0.690 |
Biomarker
|
disease |
CTD_human |
|
|
|