|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Metastatic angiomatoid fibrous histiocytoma of the scalp, with EWSR1-CREB1 gene fusions in primary tumor and nodal metastasis.
|
23199525 |
2013 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The viral genome encodes two oncoproteins, transactivator protein (Tax) and helix basic zipper protein (HBZ), which are considered tumor initiator and maintenance factors, respectively.
|
31103249 |
2020 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Recent studies have shown that the t(11;19)(q21;p13) translocation in mucoepidermoid carcinomas and benign Warthin's tumors results in a fusion of the N-terminal CREB-binding domain of the cAMP coactivator TORC1 (a.k.a.
|
15729701 |
2005 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
EWSR1 gene rearrangements including EWSR1-ATF1 or EWSR1-CREB1 GENE fusions are typically assessed in these tumors.
|
26163185 |
2015 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Although some investigators argue that CMCT is a variant of CCS, we think it should be separated from CCS, and subcutaneous/dermal CCS should be confined to tumors with EWSR1-ATF1/ CREB1 fusion.
|
31276279 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Collectively, our data demonstrate that CREB and its associated proteins play an important role in tumor growth and metastasis of human melanoma.
|
11108132 |
2000 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Afterward, pCREB1(S133) transactivated the tumor suppressor gene, EMP2, in vitro and in vivo.
|
25940704 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The tumor is characterized by the presence of EWSR1-ATF1 or EWSR1-CREB1 and immunohistochemical positivity for S-100 protein without melanocytic marker positivity.
|
27764830 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We demonstrated that T-cadherin functions as a pro-apoptotic tumor suppressor that antagonizes AKT/CREB/AP-1/FoxO3a signaling, whereas NFκB, TCF/LEF and mTOR are not part of the T-cadherin signaling pathway.
|
23625515 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Finally, when administered intraperitoneally, ART inhibited p38, ERK, STAT5, and CREB activation in tumor tissues and the growth of human CML xenograft tumors in mice without exhibiting any significant adverse effects.
|
25738364 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Overexpression of <i>VAPA-Rab31</i> upregulated anti-apoptotic protein Bcl-2 and phosphorylated CREB both in cells and xenograft tumors.
|
31083279 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings indicate that the current tumor is an additional case of PPMS with EESR1-CREB1 fusion, recently reported by Thway et al.
|
23252871 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Recurrent gene fusions involving EWSR1 with members of the cAMP response element binding protein (CREB) family (ATF1 and CREB1) have been reported in a diverse group of tumors including angiomatoid fibrous histiocytoma (AFH), soft tissue and gastrointestinal clear cell sarcoma, primary pulmonary myxoid sarcoma, and hyalinizing clear cell carcinoma of salivary gland.
|
28009602 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Expression profile comparisons with tumours of other sarcoma subtypes demonstrated that both cases clustered close to EWSR1-CREB1-positive tumours.
|
29533464 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, reduced levels of TTP are a potential biomarker for human cancers with poor outcome, and targeting the CREB pathway may be a therapeutic route for treating aggressive TTP-low tumors.
|
25541715 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The HTLV-1 transactivator protein, Tax, is believed to be crucial for the development of the disease since it is transforming in vitro and induces tumors in transgenic animals.
|
9420268 |
1998 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, the clinical data from <sup>18</sup>F-fluorodeoxyglucose positron emission tomography/computed tomography further present a strong association between the GPER/cAMP/PKA/CREB pathway of stromal fibroblasts with tumor metabolic activity and clinical treatment, suggesting that targeting cytoplasmic GPER in CAFs may rescue the drug sensitivity in patients with breast cancer.
|
27721408 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Especially in glioma, miR-200b targets the CREB1 gene and suppresses the tumor cell growth in vitro.
|
24559637 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Activating transcription factor 3 (ATF3) is a member of the ATF/CREB subfamily of the basic region-leucine zipper family and has been known as a tumor suppressor in human colorectal cancer cells.
|
20581861 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Mucoepidermoid (MEC) salivary gland tumors arise from a t(11;19) rearrangement which generates a fusion oncogene, Mect1-Maml2, that functions to activate CREB-responsive target genes.
|
16652146 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CREB1 has been shown to play a critical role in development and progression of tumors.
|
27059735 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We demonstrate that oncogenic stress chronically activates AMPK in GSCs that coopt the AMPK-CREB1 pathway to coordinate tumour bioenergetics through the transcription factors HIF1α and GABPA.
|
29915361 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, AS-IV and miR-134 increased the sensitivity of CRC tumors to oxaliplatin (OXA) chemotherapy. cAMP responsive element-binding protein 1 (CREB1), which was required for CRC cells migration, invasion and drug sensitivity, was significantly down-regulated by AS-IV.
|
29041002 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Three nuclear transcriptional factors, AP-1, CREB, and Pit-1, which are targets of protein kinase C and A, appear to play critical roles in both neoplastic growth and hormone secretion in hormone-producing adenomas.
|
10728913 |
1999 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Knockdown of CREB1 inhibits tumor growth of human gastric cancer in vitro and in vivo.
|
28498439 |
2017 |