Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma
0.060 Biomarker disease BEFREE Our recent data indicate that CREB/ATF-1 regulates the expression of AP-2α, thus, supporting the notion that CREB is an important "master switch" in melanoma progression. 21147226 2011
CUI: C0025202
Disease: melanoma
melanoma
0.060 Biomarker disease BEFREE The loss of AP-2alpha and increased activity of cAMP-responsive element binding (CREB) protein are two hallmarks of malignant progression of cutaneous melanoma. 20805990 2010
CUI: C0025202
Disease: melanoma
melanoma
0.060 AlteredExpression disease LHGDN Platelet-activating factor mediates MMP-2 expression and activation via phosphorylation of cAMP-response element-binding protein and contributes to melanoma metastasis. 16306050 2006
CUI: C0025202
Disease: melanoma
melanoma
0.060 Biomarker disease BEFREE In this prospect article, we summarize our data on the role of AP-2 and CREB/ATF-1 in the progression of human melanoma and report on the development of new fully human antibodies anti-MCAM/MUC18 and anti-IL-8 which could serve as new modalities for the treatment of melanoma. 15523674 2005
CUI: C0025202
Disease: melanoma
melanoma
0.060 Biomarker disease BEFREE Collectively, our data demonstrate that CREB and its associated proteins play an important role in tumor growth and metastasis of human melanoma. 11108132 2000
CUI: C0025202
Disease: melanoma
melanoma
0.060 AlteredExpression disease BEFREE In addition, the cell-surface adhesion molecule MCAM/MUC18 that is involved in metastasis of human melanoma was downregulated in the KCREB-transfected cells. 9366524 1997