|
Mood Disorders
|
0.400 |
Biomarker
|
group |
PSYGENET |
Various lines of evidence suggest a mechanistic role for altered cAMP-CREB (cAMP response element - binding protein) signaling in depressive and affective disorders.
|
24898566 |
2014 |
|
Mood Disorders
|
0.400 |
Biomarker
|
group |
PSYGENET |
Evaluation of the role of MAPK1 and CREB1 polymorphisms on treatment resistance, response and remission in mood disorder patients.
|
23537502 |
2013 |
|
Mood Disorders
|
0.400 |
Biomarker
|
group |
PSYGENET |
The CREB protein has been implicated in antidepressant response, suicide and mood disorders in general.
|
22574704 |
2012 |
|
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The CREB protein has been implicated in antidepressant response, suicide and mood disorders in general.
|
22574704 |
2012 |
|
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
CREB1 has previously been implicated in mood disorders, suicide, and antidepressant response.
|
21807415 |
2011 |
|
Mood Disorders
|
0.400 |
Biomarker
|
group |
PSYGENET |
CREB1 has previously been implicated in mood disorders, suicide, and antidepressant response.
|
21807415 |
2011 |
|
Mood Disorders
|
0.400 |
Biomarker
|
group |
PSYGENET |
The effects of CREB1 promoter variants on promoter activity, their influence on the development of mood disorders and related clinical features, and the interaction of their phenotypic expression with sex seem likely to be complex and allele-specific rather than a general property of the CREB1 locus.© 2010 Wiley-Liss, Inc.
|
20957653 |
2010 |
|
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Moreover, these results have been supported by a host of additional published findings that implicate sequence variations in CREB1 in the sex-dependent development of syndromic mood disorders, as well as related clinical features and disorders.
|
19517574 |
2010 |
|
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The effects of CREB1 promoter variants on promoter activity, their influence on the development of mood disorders and related clinical features, and the interaction of their phenotypic expression with sex seem likely to be complex and allele-specific rather than a general property of the CREB1 locus.© 2010 Wiley-Liss, Inc.
|
20957653 |
2010 |
|
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
A rare G-to-A transition at position -656 in the CREB1 promoter co-segregates with mood disorders in women from these families, implicating CREB1 as a sex-related susceptibility gene for unipolar mood disorders.
|
18317463 |
2009 |
|
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
A rare G to A transition at position -656 in the CREB1 promoter cosegregates with mood disorders in women from these families, implicating CREB1 as a sex-related susceptibility gene for unipolar mood disorders.
|
18213625 |
2008 |
|
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Association study of CREB1 and childhood-onset mood disorders.
|
15999345 |
2005 |
|
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Sequence variations in the CREB1 promoter and intron 8 have been detected that cosegregate with Mood Disorders, or their absence, in women from these families, identifying CREB1 as a sex-limited susceptibility gene for unipolar Mood Disorders.
|
12851637 |
2003 |
|
Mood Disorders
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The findings suggest that genes whose products participate in cellular signaling pathways that converge on CREB, as well as the target genes whose expression they regulate, may also harbor alleles that affect the development of Mood Disorders and related conditions.
|
14582139 |
2003 |
|
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Sequence variations in the CREB1 promoter and intron 8 have been detected that cosegregate with Mood Disorders, or their absence, in women from these families, identifying CREB1 as a sex-limited susceptibility gene for unipolar Mood Disorders.
|
12851637 |
2003 |
|
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Based on considerable clinical and preclinical evidence, CREB1 is an attractive candidate for a susceptibility gene for unipolar Mood Disorders.
|
12457397 |
2002 |