Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker disease BEFREE The present study investigated the role of genetic variants in the 10 neurotrophic-related genes (BDNF, NGFR, NTRK2, MTOR, VEGFA, S100A10, SERPINE1, ARHGAP33, GSK3B, CREB1) in MDD susceptibility through a case-control (455 MDD patients and 2,998 healthy controls) study and in antidepressant efficacy (n = 455). 29725086 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 GeneticVariation disease BEFREE One GNB3 polymorphism (rs5443) and four CREB1 polymorphisms (rs2253206, rs2551941, rs6740584, rs11904814) were investigated based on known associations with MD. 28225778 2017
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker disease BEFREE Our results suggest that CREB/ATF and NRF2 signaling may contribute to MDD by activating immune cell transcriptome dynamics that ultimately influence central nervous system (CNS) motivational and affective processes via circulating mediators. 27219347 2016
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker disease PSYGENET In conclusion, polymorphisms in the CREB gene may not be independently associated with MDD risk, but they are likely to confer increased susceptibility by interacting with environmental risk factors in the Chinese population. 25755794 2015
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 GeneticVariation disease BEFREE In conclusion, polymorphisms in the CREB gene may not be independently associated with MDD risk, but they are likely to confer increased susceptibility by interacting with environmental risk factors in the Chinese population. 25755794 2015
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker disease BEFREE Larger well-defined cohorts are required to confirm or refute a possible association of CREB1 and SA in female MDD patients. 24955721 2015
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker disease PSYGENET In the current study, we explored the effect of the pathogenic Creb1 allele on gene expression in the mouse hippocampus, a brain region that is altered in structure and function in MDD. 25059218 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 GeneticVariation disease BEFREE This was achieved by replacing the corresponding mouse DNA sequence with a 6-base DNA sequence from the human CREB1 promoter that is associated with the development of MDD in men and women from families identified by probands with recurrent, early-onset MDD (RE-MDD). 24006268 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 GeneticVariation disease BEFREE This study aimed to investigate the influence of CREB1 polymorphism on cognitive function in patients with MDD. 23844928 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker disease BEFREE Here, we studied the MDD-related gene CREB1 in a set of independent BD sample groups of European ancestry (a total of 64,888 subjects) and identified multiple SNPs significantly associated with BD (the most significant being SNP rs6785[A], P=6.32 × 10(-5), odds ratio (OR)=1.090). 23568192 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker disease PSYGENET This was achieved by replacing the corresponding mouse DNA sequence with a 6-base DNA sequence from the human CREB1 promoter that is associated with the development of MDD in men and women from families identified by probands with recurrent, early-onset MDD (RE-MDD). 24006268 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker disease PSYGENET This study aimed to investigate the influence of CREB1 polymorphism on cognitive function in patients with MDD. 23844928 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 GeneticVariation disease BEFREE This work also predicted that the genes with the greatest impact on model stability were those involved in the neurotrophin pathway, such as CREB, BDNF (which has been associated with major depressive disorder in a variety of studies) and TRkB, followed by genes and metabolites related to 5-HT synthesis. 24093582 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker disease PSYGENET This work also predicted that the genes with the greatest impact on model stability were those involved in the neurotrophin pathway, such as CREB, BDNF (which has been associated with major depressive disorder in a variety of studies) and TRkB, followed by genes and metabolites related to 5-HT synthesis. 24093582 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 GeneticVariation disease BEFREE The primary aim of this study was to investigate whether a set of single nucleotide polymorphisms (SNPs) within two genes implicated in neuroplasticity and inflammatory processes (the mitogen activated protein kinase 1, MAPK1 (rs3810608, rs6928, rs13515 and rs8136867), and the cyclic AMP responsive element binding protein 1, CREB1 (rs889895, rs6740584, rs2551922 and rs2254137)) was associated with antidepressant treatment resistance (according to two different definitions), in 285 Major Depressive Disorder (MDD) patients. 23537502 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 GeneticVariation disease BEFREE To explore the possible relationship between six single nucleotide polymorphisms (SNPs) (rs6311 and rs6305 of 5-HT2A, rs5443 of Gβ3, rs2230739 of ACDY9, rs1549870 of PDE1A and rs255163 of CREB1, which are all related with 5-HT2A the signal transduction pathway) and the response efficacy to selective serotonin reuptake inhibitor (SSRI) treatments in major depressive disorder (MDD) Chinese. 22480177 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker disease BEFREE IFN-α-treated patients with high depression/fatigue scores demonstrated up-regulation of genes bearing promoter motifs for transcription factors involved in myeloid differentiation, IFN-α and AP1 signaling, and reduced prevalence of motifs for CREB/ATF, which has been implicated in major depression. 22152193 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker disease BEFREE Recently, an increasing number of studies focused on the role of cyclic adenosine monophosphate response element binding protein 1 (CREB1) and Piccolo (PCLO) on MDD. 22293360 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 GeneticVariation disease BEFREE This was achieved by replacing the corresponding mouse DNA sequence with a 6-base DNA sequence from the human CREB1 promoter that is associated with the development of MDD in families identified by probands with recurrent, early-onset MDD. 22180334 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 GeneticVariation disease BEFREE Case-control association study of 14 variants of CREB1, CREBBP and CREM on diagnosis and treatment outcome in major depressive disorder and bipolar disorder. 22386572 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 AlteredExpression disease BEFREE The recombinant strain exhibited decreases in reproductive capacity and pup survival that may be related to increased infant mortality observed in RE-MDD families; enlargement of the cerebral ventricles; reduced levels of CREB protein in the mouse cerebral cortex, as predicted from transfection experiments employing the pathogenic human CREB1 promoter; and alterations in two standardized behavioral tests, the forced swim and marble burying tests. 21598377 2011
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 GeneticVariation disease BEFREE The aim of this study was to investigate the potential association of a set of single nucleotide polymorphisms (SNPs) in CREB1 gene and both MD and response, remission and treatment resistance to antidepressants. 20643483 2011
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 AlteredExpression disease BEFREE Results from previous transfection experiments that employed constructs containing the wild-type or variant CREB1 promoters coupled to a reporter gene support the hypothesis that the A(-656) allele contributes to the development of MDD in women by selectively increasing the activity of the CREB1 promoter in brain cell lines exposed to 17 β-estradiol. 20957653 2010
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 GeneticVariation disease BEFREE The results continue to support sex-specific linkage of the CREB1 region to mood disorders among women from families with RE-MDD. 19517574 2010
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 GeneticVariation disease BEFREE The results support the hypothesis that the A(-656) allele contributes to the development of MDD in women through selective alteration of CREB1 promoter activity by female gonadal steroids in noradrenergic neuronal cells. 18317463 2009