ATF2, activating transcription factor 2, 1386

N. diseases: 122; N. variants: 17
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker group BEFREE Multivariate analysis further showed that moderate/strong ATF2 expression and phospho-ATF2 positivity were independent predictors for recurrence of low-grade tumors (hazard ratio (HR) = 2.956, P = 0.045) and cancer-specific mortality of muscle-invasive tumors (HR = 5.317, P = 0.012), respectively. 30521479 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression group BEFREE Activating transcription factor 2 (ATF2) is a multifunctional transcription factor, and is implicated in tumor progress, yet its role in pancreatic cancer remains unclear. 28318081 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression group BEFREE Moreover, ATF2 was shown to be highly expressed in RCC tissues, especially in tumors with metastases. 27377902 2016
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker group BEFREE The mitochondrial accumulation of ATF2 is involved in tumor suppressor activities via cytochrome c release in melanoma cells. 26462148 2015
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression group BEFREE Notably, nuclear ATF2 and low expression of IFNβ1 in melanoma tumor samples correlates with poor patient responsiveness to biochemotherapy or neoadjuvant IFN-α2a. 25728676 2015
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker group BEFREE Activating transcription factor-2 (ATF-2) has been implicated as a tumour suppressor in breast cancer (BC). c-JUN N-terminal kinase (JNK) and p38 MAPK phosphorylate ATF-2 within the activation domain (AD), which is required for its transcriptional activity. 25141981 2014
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker group BEFREE Here, we show ATF2 suppresses tumor formation in an orthotopic model of liver cancer and cellular transformation in vitro. 25456131 2014
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression group BEFREE Herein we perform immunohistochemical analyses using a validated specific antibody for ATF2 expression and intracellular localization on a cohort of 594 malignant and 207 benign mesenchymal tumors representing 47 diagnostic entities. 24289970 2014
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker group CTD_human Oxidative stress and MAPK involved into ATF2 expression in immortalized human urothelial cells treated by arsenic. 23591579 2013
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker group BEFREE Activating transcription factor 2 (ATF2; also known as cAMP-dependent transcription factor ATF-2) has oncogenic activities in melanoma and tumor suppressor activities in non-malignant skin tumors and breast cancer. 22685333 2012
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker group BEFREE Moreover nuclear factor (NF)-κB and other transcription factors like CREB, ATF-2 involved in tumour development and angiogenesis were also inhibited by harmine. 20858484 2010
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression group BEFREE The transcription factor ATF2 has been shown to attenuate melanoma susceptibility to apoptosis and to promote its ability to form tumors in xenograft models. 21203491 2010
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker group BEFREE Yet work in other tumor models, including breast and skin tumors reveals that ATF2, in cooperation with mutated oncogenes or tumor suppressor genes, can also elicit tumor suppressor function. 18677098 2008
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker group BEFREE These studies suggest the functional link between the ATF-2 and the two tumor suppressors BRCA1 and p53. 17700520 2008
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker group BEFREE Thus, ATF-2 acts as a tumor susceptibility gene of mammary tumors, at least partly, by activating a group of target genes, including Maspin and Gadd45alpha. 17189429 2007
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker group BEFREE To assess the role of the ATF-2 gene as a tumor suppressor in human carcinogenesis, we examined genetic alterations of the ATF-2 gene in 9 breast cancer cell lines, 10 neuroblastoma cell lines and 46 lung cancer cell lines. 11836564 2002
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker group BEFREE Our results suggest that ATF2 is a regulator of radiation and drug resistance in melanomas, and that tumor targeted ATF2 modulators may be useful sensitizers in the treatment of tumors of this type. 9484842 1998
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression group BEFREE Furthermore, the levels of CRE-BP1 mRNA in some clinical samples of human tumors were apparently higher than that in normal tissues. 1829805 1991