CREM, cAMP responsive element modulator, 1390

N. diseases: 100; N. variants: 14
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.080 Biomarker group BEFREE Universal germline gene panel testing was not cost-effective compared with universal tumour testing strategies (ICER, $2.4 million/LYS). 31595523 2020
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.080 Biomarker group BEFREE EWSR1-CREM fusions have not been previously reported in CCC and have only rarely been reported in other tumors. 29975250 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.080 AlteredExpression group BEFREE This tumor acidosis induced Gprotein-coupled receptor-dependent expression of the transcriptional repressor ICER in tumor-associated macrophages that led to their functional polarization toward a non-inflammatory phenotype and promoted tumor growth. 30397348 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.080 Biomarker group BEFREE Although this is a known gene fusion found in various mesenchymal tumors, EWSR1 fusion with CREM has only been observed in 3 intracranial myxoid tumors. 29788195 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.080 Biomarker group BEFREE A novel EWSR1-CREM fusion was identified by RNA sequencing in the perirectal tumor, which was further confirmed by fluorescence in situ hybridization (FISH) and reverse transcription-polymerase chain reaction (RT-PCR). 28009602 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.080 Biomarker group BEFREE Our data suggested that CREM-1 might play an important role in the regulation of tumor metastasis and invasion and serve as a tumor suppressor in human ESCC. 23929392 2013
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.080 AlteredExpression group BEFREE In our study we focused on the expression of CREB and ICER genes in the nodular as well as in the extranodular tissue of hyperfunctioning tumours of the thyroid. 12039695 2002
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.080 Biomarker group BEFREE These ICER-bearing LNCaP cells were rendered unable to grow in soft agar and unable to form tumors in nude mice. 11507053 2001