CRH, corticotropin releasing hormone, 1392

N. diseases: 402; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE We conclude that androgens may directly affect CRH neurons in the human PVN via AR binding to the CRH-ARE, which may have consequences for sex-specific pathogenesis of mood disorders. 16446741 2006
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE The density of RAR-alpha-immunoreactive neurons and CRH-RAR-alpha double-staining neurons was significantly increased in the PVN of patients with affective disorders. 19596122 2009
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group PSYGENET Corticotropin-releasing factor-binding protein regulates the availability of free corticotropin-releasing factor and is a functional candidate gene for affective disorders. 17728670 2007
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group PSYGENET Corticotropin-releasing factor-binding protein (CRF-BP) regulates the availability of free CRF and is a functional candidate gene for affective disorders. 17599466 2007
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 GeneticVariation group BEFREE Dysfunction of the CRF system has been observed in stress-related affective disorders including post-traumatic stress disorder, depression, and anxiety. 31212019 2019
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE The most robustly confirmed neuroendocrine finding among psychiatric patients with affective disorders is hyperactivity of the hypothalamic-pituitary-adrenocortical (HPA) system, resulting from hyperactive hypothalamic corticotropin-releasing hormone (CRH) neurons. 11337098 2001
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE Dysfunctioning of corticotropin-releasing factor (CRF) and its receptors (CRF(1) and CRF(2)) has been linked to the development of stress-related disorders, such as affective disorders and drug abuse. 16611089 2006
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 AlteredExpression group BEFREE Decades of research have described the importance of corticotropin-releasing factor (CRF) signaling in alcohol addiction, as well as in commonly co-expressed neuropsychiatric diseases, including anxiety and mood disorders. 30217435 2018
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE These findings show that stress activates BNST CRF neurons, and that α<sub>2A</sub>-AR activation suppresses the <i>in vivo</i> activity of these cells, at least in part by suppressing excitatory drive from PBN inputs onto CRF neurons.<b>SIGNIFICANCE STATEMENT</b> Stress is a major variable contributing to mood disorders. 30478032 2019
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE These results indicate that the central CRF signal, rather than the peripheral CRF signal would be related to anxiety and other behavioral changes, and CRF<sub>1</sub> receptor antagonism in the central nervous system may be critical for identifying drug candidates for anxiety and mood disorders. 28689880 2017
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group PSYGENET Hypersecretion of central corticotropin-releasing hormone (CRH) has been implicated in the pathophysiology of affective disorders. 18475271 2008
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE Our present findings give further evidence that the blockage of CRF action may be useful in the treatment of mood disorders. 28429110 2017
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE Getting closer to affective disorders: the role of CRH receptor systems. 15310462 2004
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group PSYGENET Corticotropin-releasing factor (CRF), its receptors, and signaling pathways that regulate CRF expression and responses are areas of intense investigation for new drugs to treat affective disorders. 17908177 2008
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE Corticotropin-releasing factor-binding protein (CRF-BP) regulates the availability of free CRF and is a functional candidate gene for affective disorders. 17599466 2007
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group PSYGENET The ratio of the CRH-RAR-alpha double-staining neurons to the CRH-immunoreactive neurons in affective disorder patients was also increased. 19596122 2009
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE Listening to mutant mice: a spotlight on the role of CRF/CRF receptor systems in affective disorders. 15899517 2005
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 AlteredExpression group BEFREE The activation and expression of glucocorticoids and CRH are variable and may hold important clues to individual experiences of mood disorders. 28119322 2017
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE Corticotropin-releasing factor-binding protein regulates the availability of free corticotropin-releasing factor and is a functional candidate gene for affective disorders. 17728670 2007
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE Corticotropin-releasing factor binds with high affinity to CRF receptor 1 (CRFR1) and is implicated in stress-related mood disorders such as anxiety and depression. 30499109 2019
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE Given the fundamental role of the corticotropin-releasing hormone (CRH) system in anxiety, stress-associated pathologies, and mood disorders, we describe genetic modifications of the genes that encode proteins integral to the CRH/CRH receptor system with particular emphasis on conditional gene-targeting strategies. 14755129 2004