CRH, corticotropin releasing hormone, 1392

N. diseases: 402; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036572
Disease: Seizures
Seizures
0.320 Biomarker phenotype CTD_human When some gamma-endorphin derivatives (DT gamma E, DE gamma E) were injected intravenously (i.v.) for 4 days (or hydrocortisone once), they prevented the EEG ictal seizures induced in the hippocampus of rabbits by CRF injected i.c.v. 1700951 1991
CUI: C0036572
Disease: Seizures
Seizures
0.320 Biomarker phenotype CTD_human Corticotropin-releasing hormone-induced electrographic and behavioral seizures originate in the amygdala. 1596084 1992
CUI: C0036572
Disease: Seizures
Seizures
0.320 Biomarker phenotype CTD_human Administration of CRH, an age-specific endogenous convulsant, resulted in a prolonged series of seizures after 2- to 55-min latency. 7821275 1995
CUI: C0036572
Disease: Seizures
Seizures
0.320 Biomarker phenotype CTD_human C-fos expression after icv CRF has been considered a useful tool in mapping areas involved in stress and in seizure activity. 8923670 1996
CUI: C0036572
Disease: Seizures
Seizures
0.320 Biomarker phenotype CTD_human The increase in GAT-1-ir somata in the CRH model and not in the hyperthermia model may reflect the difference in the duration of seizures. 11074187 2000
CUI: C0036572
Disease: Seizures
Seizures
0.320 Biomarker phenotype CTD_human CRH-induced seizures occurred prior to any changes in serum corticosterone, and were eliminated by the administration of a CRH antagonist, as well as of phenytoin. 1914160 1991
CUI: C0036572
Disease: Seizures
Seizures
0.320 Biomarker phenotype BEFREE The stress theory of spasms yielded the corticotropin releasing hormone (CRH)-induced model, which showed the higher proconvulsant potency of CRH in developing rats, although only limbic seizures were observed. 23312951 2013
CUI: C0036572
Disease: Seizures
Seizures
0.320 Biomarker phenotype BEFREE Similarly, chemogenetic activation of CRH neurons in the paraventricular nucleus (PVN) is sufficient to increase seizure susceptibility; whereas, chemogenetic inhibition of CRH neurons in the PVN of the hypothalamus is sufficient to decrease seizure susceptibility and depression-like behaviors in chronically epileptic mice. 29186699 2018