CRH, corticotropin releasing hormone, 1392

N. diseases: 402; N. variants: 2
Disease: Depressive disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease BEFREE CRF overproduction has been implicated in affective disorders, such as depression and anorexia nervosa, and may lead to Cushing's syndrome. 1597149 1992
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease BEFREE These data indicate that CRF receptor antagonists may be useful for the treatment of the disease states where CRF is elevated such as anxiety and depression, anorexia nervosa and stroke and that ligand inhibitors of CRF-BP may be used to elevate brain levels of 'free' urocortin and other CRF-related peptides. 9118350 1996
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease BEFREE Abnormalities in CRH secretion have been documented in both the depression and manic phases of bipolar disorder (BPD). 9399692 1998
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease BEFREE More refined analysis of the HPA system revealed that corticosteroid receptor (CR) signaling is impaired in major depression, resulting among other changes, in increased production and secretion of corticotropin-releasing hormone (CRH, also frequently abbreviated CRF) in various brain regions postulated to be involved in the causality of depression. 11027914 2000
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease BEFREE The Dex/CRH test is one of the most reliable neuroendocrine function tests for hypothalamic-pituitary-adrenocortical (HPA) system dysregulation in depression. 12147330 2002
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease CTD_human Patients suffering from depression have abnormal activity in stress responsive brain regions and elevated cerebrospinal fluid CRF. 12438692 2002
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 AlteredExpression disease BEFREE Levels of corticotropin-releasing hormone are elevated in patients with depression and anxiety and are expected to be elevated in patients with congenital adrenal hyperplasia; it is unknown whether patients with 21-hydroxylase deficiency have an increased incidence of these psychiatric disorders. 11848730 2002
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease BEFREE Because both cortisol and CRH have behavioral effects, and hypothalamic CRH hypersecretion has been associated with chronic states of anxiety and depression, we performed endocrine and psychologic studies in consecutively admitted parents of patients with classic congenital adrenal hyperplasia due to 21-OH deficiency and parents of children with other chronic endocrine disorders. 15126546 2004
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease BEFREE There are well-replicated, independent lines of evidence supporting a role for corticotropin-releasing hormone (CRH) in the pathophysiology of depression. 15365580 2004
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease BEFREE These findings raise the possibility that the CRH and GABA(A) receptor subunit changes, or the disturbed coordination between these GABA(A) receptor subunits, contribute to depression and/or suicidality or are secondary to the illness/distress associated with it. 14960621 2004
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 GeneticVariation disease BEFREE Early-life adversity, such as physical or sexual abuse during childhood, results in long-lasting changes in the CRF-mediated stress response and a greatly increased risk of depression in genetically predisposed persons. 16124836 2005
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 GeneticVariation disease BEFREE Numerous reports suggest that alterations in CRF function contribute to the pathogenesis of depression. 16122764 2006
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease BEFREE Corticotropin-releasing hormone (CRH) has been implicated in the pathophysiology of anxiety disorders and depression. 16884458 2006
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease BEFREE Corticotropin-releasing factor, vasopressin and receptor systems in depression and anxiety. 16733617 2006
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease BEFREE Hyperactivity of corticotropin-releasing factor (CRF) neurons in the paraventricular nucleus (PVN) of the hypothalamus is a prominent feature in depression and may be important in the etiology of this disease. 18427561 2008
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease BEFREE Indeed, animal studies have shown that vulnerability to depressive-like behaviors involve mechanisms similar to those associated with human depression (e.g., altered serotonin, corticotropin releasing hormone and their receptors, growth factors), and that the effects of stressors are influenced by previous stressor experiences, particularly those encountered early in life. 18423590 2008
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 AlteredExpression disease BEFREE Child abuse and trauma alter the endogenous stress response, principally corticotropin-releasing hormone and its downstream effectors, suggesting that a gene x environment interaction at this locus may be important in depression. 18250257 2008
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 AlteredExpression disease BEFREE These results suggest that RAR-alpha might contribute to regulating the activity of CRH neurons in vivo, and the vulnerable character of the critical proteins in RA signaling pathways might provide novel targets for therapeutic strategies for depression. 19596122 2009
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 GeneticVariation disease BEFREE Variation in the corticotropin-releasing hormone receptor (CRHR1) gene has been shown to interact with early life stress to predict adult depression. 19596121 2009
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease CTD_human Increased synthesis of CRF in CeA amplified CRF and arginine vasopressin peptide concentration in the paraventricular nucleus of the hypothalamus, and decreased glucocorticoid negative feedback, both markers associated with the pathophysiology of depression. 18698320 2009
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 GeneticVariation disease BEFREE Recently, two studies have reported an interaction between childhood abuse and the TAT-haplotype of the CRH-Receptor Gene (CRHR1) connecting childhood adversities and genetic susceptibility to adult depression. 20957648 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease BEFREE A concatenation of findings from preclinical and clinical studies support a preeminent function for the corticotropin-releasing factor (CRF) system in mediating the physiological response to external stressors and in the pathophysiology of anxiety and depression. 20010888 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 AlteredExpression disease BEFREE We propose that full-length dendritic cell nucleus protein-1 may play a role in the pathogenesis of depressive disorders by enhancing corticotropin-releasing hormone expression in the hypothalamic paraventricular nucleus. 20693543 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease BEFREE REST has many target genes, including corticotropin releasing hormone (CRH), brain-derived neurotrophic factor, serotonin 1A receptor, which are suggested to be involved in the pathophysiology of depression and the action of antidepressants. 19846118 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease BEFREE The corticotropin-releasing factor (CRF, or corticotropin-releasing hormone) and arginine vasopressin systems have been implicated in the pathophysiology of anxiety and depressive disorders and response to antidepressant treatment. 20368512 2010