|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association of glucocorticoid and type 1 corticotropin-releasing hormone receptors gene variants and risk for depression during pregnancy and post-partum.
|
23726670 |
2013 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, 5-HT2CR signaling enhancement and the subsequent activation of the CRF neuron were involved in novelty-induced hypophagia in aged mice, and the 5-HT2CR antagonists offer a promising therapeutic option for depression.
|
23583320 |
2013 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Recent molecular studies of expression of serotonin, GABA and CRH receptors in various brain regions have demonstrated that molecular factors may contribute to the development of depressive disorder and suicide behaviour.
|
23110080 |
2012 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
In addition, elevated CRF in cerebrospinal fluid is observed in mood and anxiety disorder patients, suggesting that CRF is also being overproduced from extrahypothalamic sources such as the central amygdala (CeA) and overactivity of the amygdala in neuroimaging studies is a consistent finding in anxiety and depression patients.
|
21616602 |
2012 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Corticotropin-releasing factor (CRF) has a key role in the central stress response, and altered levels of this neuropeptide are linked to stress-related psychopathologies such as anxiety and depression.
|
20548294 |
2011 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Recently, two studies have reported an interaction between childhood abuse and the TAT-haplotype of the CRH-Receptor Gene (CRHR1) connecting childhood adversities and genetic susceptibility to adult depression.
|
20957648 |
2010 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
A concatenation of findings from preclinical and clinical studies support a preeminent function for the corticotropin-releasing factor (CRF) system in mediating the physiological response to external stressors and in the pathophysiology of anxiety and depression.
|
20010888 |
2010 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We propose that full-length dendritic cell nucleus protein-1 may play a role in the pathogenesis of depressive disorders by enhancing corticotropin-releasing hormone expression in the hypothalamic paraventricular nucleus.
|
20693543 |
2010 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
REST has many target genes, including corticotropin releasing hormone (CRH), brain-derived neurotrophic factor, serotonin 1A receptor, which are suggested to be involved in the pathophysiology of depression and the action of antidepressants.
|
19846118 |
2010 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The corticotropin-releasing factor (CRF, or corticotropin-releasing hormone) and arginine vasopressin systems have been implicated in the pathophysiology of anxiety and depressive disorders and response to antidepressant treatment.
|
20368512 |
2010 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that RAR-alpha might contribute to regulating the activity of CRH neurons in vivo, and the vulnerable character of the critical proteins in RA signaling pathways might provide novel targets for therapeutic strategies for depression.
|
19596122 |
2009 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Variation in the corticotropin-releasing hormone receptor (CRHR1) gene has been shown to interact with early life stress to predict adult depression.
|
19596121 |
2009 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
CTD_human |
Increased synthesis of CRF in CeA amplified CRF and arginine vasopressin peptide concentration in the paraventricular nucleus of the hypothalamus, and decreased glucocorticoid negative feedback, both markers associated with the pathophysiology of depression.
|
18698320 |
2009 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Hyperactivity of corticotropin-releasing factor (CRF) neurons in the paraventricular nucleus (PVN) of the hypothalamus is a prominent feature in depression and may be important in the etiology of this disease.
|
18427561 |
2008 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Indeed, animal studies have shown that vulnerability to depressive-like behaviors involve mechanisms similar to those associated with human depression (e.g., altered serotonin, corticotropin releasing hormone and their receptors, growth factors), and that the effects of stressors are influenced by previous stressor experiences, particularly those encountered early in life.
|
18423590 |
2008 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Child abuse and trauma alter the endogenous stress response, principally corticotropin-releasing hormone and its downstream effectors, suggesting that a gene x environment interaction at this locus may be important in depression.
|
18250257 |
2008 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Numerous reports suggest that alterations in CRF function contribute to the pathogenesis of depression.
|
16122764 |
2006 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Corticotropin-releasing hormone (CRH) has been implicated in the pathophysiology of anxiety disorders and depression.
|
16884458 |
2006 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Corticotropin-releasing factor, vasopressin and receptor systems in depression and anxiety.
|
16733617 |
2006 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Early-life adversity, such as physical or sexual abuse during childhood, results in long-lasting changes in the CRF-mediated stress response and a greatly increased risk of depression in genetically predisposed persons.
|
16124836 |
2005 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Because both cortisol and CRH have behavioral effects, and hypothalamic CRH hypersecretion has been associated with chronic states of anxiety and depression, we performed endocrine and psychologic studies in consecutively admitted parents of patients with classic congenital adrenal hyperplasia due to 21-OH deficiency and parents of children with other chronic endocrine disorders.
|
15126546 |
2004 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
There are well-replicated, independent lines of evidence supporting a role for corticotropin-releasing hormone (CRH) in the pathophysiology of depression.
|
15365580 |
2004 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
These findings raise the possibility that the CRH and GABA(A) receptor subunit changes, or the disturbed coordination between these GABA(A) receptor subunits, contribute to depression and/or suicidality or are secondary to the illness/distress associated with it.
|
14960621 |
2004 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The Dex/CRH test is one of the most reliable neuroendocrine function tests for hypothalamic-pituitary-adrenocortical (HPA) system dysregulation in depression.
|
12147330 |
2002 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
CTD_human |
Patients suffering from depression have abnormal activity in stress responsive brain regions and elevated cerebrospinal fluid CRF.
|
12438692 |
2002 |