CRH, corticotropin releasing hormone, 1392

N. diseases: 274; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 GeneticVariation disease BEFREE Early life stress (ELS) is associated with increased vulnerability for depression, changes to the corticotropin-releasing hormone (CRH) system and structural and functional changes in hippocampus. 28461011 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE Clinical application of DEX/CRH test and multi-channel NIRS in patients with depression. 27582123 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease PSYGENET Correlation analysis indicated that the alteration of multiple CRF-controlling receptors is highly correlated with depression-related behaviors of rats in the forced swimming test. 25578258 2015
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease PSYGENET Sensitizing effect of early adversity on depressive reactions to later proximal stress: Moderation by polymorphisms in serotonin transporter and corticotropin releasing hormone receptor genes in a 20-year longitudinal study. 25422958 2015
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease PSYGENET Because dysregulation of CRH expression occurs in stress-related disorders including depression, a full understanding of the complex regulation of this gene is important in both health and disease. 23768074 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease PSYGENET Association of glucocorticoid and type 1 corticotropin-releasing hormone receptors gene variants and risk for depression during pregnancy and post-partum. 23726670 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 AlteredExpression disease BEFREE In conclusion, 5-HT2CR signaling enhancement and the subsequent activation of the CRF neuron were involved in novelty-induced hypophagia in aged mice, and the 5-HT2CR antagonists offer a promising therapeutic option for depression. 23583320 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease PSYGENET The corticotropin releasing hormone (CRH) and the CRH receptor 1 (CRHR1) have been implicated in the link between early life adversity and adult anxiety and depression, with rodent studies identifying the very early postnatal period as highly susceptible to this programming. 24630468 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 GeneticVariation disease BEFREE Association of glucocorticoid and type 1 corticotropin-releasing hormone receptors gene variants and risk for depression during pregnancy and post-partum. 23726670 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE Recent molecular studies of expression of serotonin, GABA and CRH receptors in various brain regions have demonstrated that molecular factors may contribute to the development of depressive disorder and suicide behaviour. 23110080 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE In addition, elevated CRF in cerebrospinal fluid is observed in mood and anxiety disorder patients, suggesting that CRF is also being overproduced from extrahypothalamic sources such as the central amygdala (CeA) and overactivity of the amygdala in neuroimaging studies is a consistent finding in anxiety and depression patients. 21616602 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 GeneticVariation disease BEFREE Childhood maltreatment, the corticotropin-releasing hormone receptor gene and adult depression in the general population. 20957648 2011
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 AlteredExpression disease BEFREE Corticotropin-releasing factor (CRF) has a key role in the central stress response, and altered levels of this neuropeptide are linked to stress-related psychopathologies such as anxiety and depression. 20548294 2011
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE A concatenation of findings from preclinical and clinical studies support a preeminent function for the corticotropin-releasing factor (CRF) system in mediating the physiological response to external stressors and in the pathophysiology of anxiety and depression. 20010888 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 AlteredExpression disease BEFREE These results suggest that RAR-alpha might contribute to regulating the activity of CRH neurons in vivo, and the vulnerable character of the critical proteins in RA signaling pathways might provide novel targets for therapeutic strategies for depression. 19596122 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE REST has many target genes, including corticotropin releasing hormone (CRH), brain-derived neurotrophic factor, serotonin 1A receptor, which are suggested to be involved in the pathophysiology of depression and the action of antidepressants. 19846118 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 AlteredExpression disease BEFREE We propose that full-length dendritic cell nucleus protein-1 may play a role in the pathogenesis of depressive disorders by enhancing corticotropin-releasing hormone expression in the hypothalamic paraventricular nucleus. 20693543 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE The corticotropin-releasing factor (CRF, or corticotropin-releasing hormone) and arginine vasopressin systems have been implicated in the pathophysiology of anxiety and depressive disorders and response to antidepressant treatment. 20368512 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease CTD_human Increased synthesis of CRF in CeA amplified CRF and arginine vasopressin peptide concentration in the paraventricular nucleus of the hypothalamus, and decreased glucocorticoid negative feedback, both markers associated with the pathophysiology of depression. 18698320 2009
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 GeneticVariation disease BEFREE Variation in the corticotropin-releasing hormone receptor (CRHR1) gene has been shown to interact with early life stress to predict adult depression. 19596121 2009
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE Indeed, animal studies have shown that vulnerability to depressive-like behaviors involve mechanisms similar to those associated with human depression (e.g., altered serotonin, corticotropin releasing hormone and their receptors, growth factors), and that the effects of stressors are influenced by previous stressor experiences, particularly those encountered early in life. 18423590 2008
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE Hyperactivity of corticotropin-releasing factor (CRF) neurons in the paraventricular nucleus (PVN) of the hypothalamus is a prominent feature in depression and may be important in the etiology of this disease. 18427561 2008
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE Corticotropin-releasing factor, vasopressin and receptor systems in depression and anxiety. 16733617 2008
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 GeneticVariation disease BEFREE These data support the corticotropin-releasing hormone hypothesis of depression and suggest that a gene x environment interaction is important for the expression of depressive symptoms in adults with CRHR1 risk or protective alleles who have a history of child abuse. 18250257 2008
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 GeneticVariation disease BEFREE Numerous reports suggest that alterations in CRF function contribute to the pathogenesis of depression. 16122764 2006