CRH, corticotropin releasing hormone, 1392

N. diseases: 274; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030193
Disease: Pain
Pain
0.320 Biomarker phenotype BEFREE Corticotropin-releasing factor mediates bone cancer induced pain through neuronal activation in rat spinal cord. 26138585 2016
CUI: C0030193
Disease: Pain
Pain
0.320 Therapeutic phenotype CTD_human This study examines the contribution of central corticotropin-releasing factor (CRF) to pain behavior. 16495007 2006
CUI: C0030193
Disease: Pain
Pain
0.320 Therapeutic phenotype CTD_human We compared nociceptive thresholds (heat and mechanical) and pain behavior in response to a sustained stimulus (formalin test) between Fischer and Lewis rats that have different HPA axis activity.Intracerebroventricular (i.c.v.) administration of CRF produced dose-dependent antinociception at a lower dose in Lewis (40 ng, paw pinch 71+/-0 g) compared to Fischer rats (200 ng, 112+/-3 g). 16495007 2006
CUI: C0030193
Disease: Pain
Pain
0.320 Therapeutic phenotype CTD_human In the formalin test, CRF and astressin had the largest effect on the interphase suggesting that they act on the endogenous pain inhibitory system. 16495007 2006
CUI: C0030193
Disease: Pain
Pain
0.320 Therapeutic phenotype CTD_human Our results establish that central CRF is a key modulator of pain behavior and indicates that CRF effects on nociception are largely independent of its mood modulating effect as well as its control of the HPA axis. 16495007 2006
CUI: C0030193
Disease: Pain
Pain
0.320 Biomarker phenotype BEFREE The peripheral paracrine effects of CRF may be similar to those of hypothalamic CRF, i.e., to counterbalance local stressful events, such as inflammation and pain, so that they do not threaten the homeostasis of the body. 9105870 1997