CRH, corticotropin releasing hormone, 1392

N. diseases: 274; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036572
Disease: Seizures
Seizures
0.310 Biomarker phenotype BEFREE The stress theory of spasms yielded the corticotropin releasing hormone (CRH)-induced model, which showed the higher proconvulsant potency of CRH in developing rats, although only limbic seizures were observed. 23312951 2014
CUI: C0036572
Disease: Seizures
Seizures
0.310 Biomarker phenotype CTD_human The increase in GAT-1-ir somata in the CRH model and not in the hyperthermia model may reflect the difference in the duration of seizures. 11074187 2000
CUI: C0036572
Disease: Seizures
Seizures
0.310 Biomarker phenotype CTD_human The number of GAT-1-immunoreactive (ir) neurons was increased in several forebrain regions 24 h after induction of seizures by CRH as compared to the control group. 11074187 2000
CUI: C0036572
Disease: Seizures
Seizures
0.310 Biomarker phenotype CTD_human The present study examined GAT-1-immunolabeling in infant rats with two types of developmental seizures, one induced by corticotropin-releasing hormone (CRH) lasting about 2 h and the other by hyperthermia (a model of febrile seizures) lasting only 20 min. 11074187 2000
CUI: C0036572
Disease: Seizures
Seizures
0.310 Biomarker phenotype CTD_human Increased expression of gamma-aminobutyric acid transporter-1 in the forebrain of infant rats with corticotropin-releasing hormone-induced seizures but not in those with hyperthermia-induced seizures. 11074187 2000
CUI: C0036572
Disease: Seizures
Seizures
0.310 Biomarker phenotype CTD_human C-fos expression after icv CRF has been considered a useful tool in mapping areas involved in stress and in seizure activity. 8923670 1997
CUI: C0036572
Disease: Seizures
Seizures
0.310 Biomarker phenotype CTD_human C-Fos expression as a molecular marker in corticotropin-releasing factor-induced seizures. 8923670 1997
CUI: C0036572
Disease: Seizures
Seizures
0.310 Biomarker phenotype CTD_human CRH-induced seizure duration (88.2 +/- 9 vs. 74.7 +/- 9.4 min) and severity of seizures was also unchanged by ACTH treatment. 7821275 1995
CUI: C0036572
Disease: Seizures
Seizures
0.310 Biomarker phenotype CTD_human We tested ACTH activity against exogenous corticotropin-releasing hormone (CRH)-induced seizures in the infant rat model. 7821275 1995
CUI: C0036572
Disease: Seizures
Seizures
0.310 Biomarker phenotype CTD_human Administration of CRH, an age-specific endogenous convulsant, resulted in a prolonged series of seizures after 2- to 55-min latency. 7821275 1995
CUI: C0036572
Disease: Seizures
Seizures
0.310 Biomarker phenotype CTD_human Corticotropin-releasing hormone-induced seizures in infant rats originate in the amygdala. 1596084 1992
CUI: C0036572
Disease: Seizures
Seizures
0.310 Biomarker phenotype CTD_human Corticotropin-releasing hormone-induced electrographic and behavioral seizures originate in the amygdala. 1596084 1992
CUI: C0036572
Disease: Seizures
Seizures
0.310 Biomarker phenotype CTD_human The neuroanatomical substrate of seizures induced by picomolar amounts of corticotropin-releasing hormone in infant rats was investigated. 1596084 1992
CUI: C0036572
Disease: Seizures
Seizures
0.310 Biomarker phenotype CTD_human The administration of corticotropin-releasing hormone produced age-specific seizures within minutes, which correlated with rhythmic amygdala discharges. 1596084 1992
CUI: C0036572
Disease: Seizures
Seizures
0.310 Biomarker phenotype CTD_human Some endorphin derivatives and hydrocortisone prevent EEG limbic seizures induced by corticotropin-releasing factor in rabbits. 1700951 1991
CUI: C0036572
Disease: Seizures
Seizures
0.310 Biomarker phenotype CTD_human Corticotropin-releasing hormone (CRH) administered into the cerebral ventricles of rats during the first postnatal week caused a specific and stereotyped behavior sequence: rhythmic chewing and licking (jaw myoclonus) were followed by 'limbic'-type seizures. 1914160 1991
CUI: C0036572
Disease: Seizures
Seizures
0.310 Biomarker phenotype CTD_human CRH potency in inducing seizures varied inversely with age. 1914160 1991
CUI: C0036572
Disease: Seizures
Seizures
0.310 Biomarker phenotype CTD_human Corticotropin-releasing factor (CRF) injected into the cerebral ventricles of small mammals induces EEG limbic seizures, behavioral excitability, stereotyped behavior, and tardive enhancement of hippocampal theta voltage and frequency. 1700951 1991
CUI: C0036572
Disease: Seizures
Seizures
0.310 Biomarker phenotype CTD_human CRH-induced seizures occurred prior to any changes in serum corticosterone, and were eliminated by the administration of a CRH antagonist, as well as of phenytoin. 1914160 1991
CUI: C0036572
Disease: Seizures
Seizures
0.310 Biomarker phenotype CTD_human When some gamma-endorphin derivatives (DT gamma E, DE gamma E) were injected intravenously (i.v.) for 4 days (or hydrocortisone once), they prevented the EEG ictal seizures induced in the hippocampus of rabbits by CRF injected i.c.v. 1700951 1991