CRH, corticotropin releasing hormone, 1392

N. diseases: 402; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker disease BEFREE The changes in, and relationship between, plasma nitric oxide and corticotropin-releasing hormone in patients with major depressive disorder. 28755509 2018
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker disease BEFREE Corticotropin-releasing factor 1 receptor haplotype and cognitive features of major depression. 29317606 2018
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 GeneticVariation disease BEFREE Association analysis for corticotropin releasing hormone polymorphisms with the risk of major depressive disorder and the response to antidepressants. 26055202 2015
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker disease BEFREE Evidence for the role of corticotropin-releasing factor in major depressive disorder. 26271720 2015
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker disease BEFREE Our findings argue for a role of the SLC6A15 gene in ACTH and cortisol secretion during the Dex/CRH test and furthermore in the occurrence of cognitive impairments in unipolar depression. 22475622 2013
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker disease PSYGENET Negative life events and corticotropin-releasing-hormone receptor1 gene in recurrent major depressive disorder. 23529111 2013
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker disease PSYGENET Our findings argue for a role of the SLC6A15 gene in ACTH and cortisol secretion during the Dex/CRH test and furthermore in the occurrence of cognitive impairments in unipolar depression. 22475622 2013
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker disease PSYGENET Variation in the corticotropin-releasing hormone receptor 1 (CRHR1) gene influences fMRI signal responses during emotional stimulus processing. 22378896 2012
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker disease PSYGENET In addition, persistent elevation of cerebrospinal fluid (CSF) corticotropin-releasing factor (CRF) concentrations following early-life adversity has been posited to underlie the subsequent development of major depression. 20692103 2011
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker disease PSYGENET Our results suggest that the aberrant REST-mediated transcriptional regulation of, at least, CRH, adenylate cyclase 5, and tumor necrosis factor superfamily, member 12-13, might be state-dependent and associated with the pathophysiology of major depression. 19846118 2010
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 AlteredExpression disease BEFREE We found reduced mRNA expression of REST and increased mRNA expression of CRH, adenylate cyclase 5, and the tumor necrosis factor superfamily, member 12-13 in patients with major depressive disorder in a current depressive state, but not in a remissive state. 19846118 2010
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker disease CTD_human Continuous expression of corticotropin-releasing factor in the central nucleus of the amygdala emulates the dysregulation of the stress and reproductive axes. 18698320 2009
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker disease BEFREE Many pieces of evidence supported that corticotropin-releasing hormone (CRH) play a role in the pathophysiology of major depression. 16815632 2006
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker disease BEFREE A function test combining the pre-treatment of 1.5 mg dexamethasone (DEX) with a challenge of 100 microg corticotropin-releasing hormone (CRH) reveals a pathological increase in the adrenocorticotropin and cortisol release in patients with major depression. 15504420 2005
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker disease BEFREE CRH, stress, and major depression: a psychobiological interplay. 15196881 2004
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker disease BEFREE Recent research suggests that central corticotropin releasing hormone hyperdrive is an important neurobiological risk factor for developing major depression. 14573312 2003
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker disease CTD_human Intracerebroventricular corticotropin-releasing factor increases limbic glucose metabolism and has social context-dependent behavioral effects in nonhuman primates. 12438692 2002
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker disease BEFREE This differential effect of glucocorticoid on CRH mRNA regulation could help explain the abnormal CRH production observed in clinical disorders such as anorexia nervosa and major depression. 1547737 1992