Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Pituitary-dependent Cushing's disease
0.100 Biomarker disease BEFREE Here, we prospectively evaluated the utility of CRH stimulation in improving <sup>18</sup>F-FDG-PET detection of adenomas in CD. 31062234 2019
Pituitary-dependent Cushing's disease
0.100 Biomarker disease BEFREE Pituitary magnetic resonance imaging (MRI) revealed a 3.5 mm microadenoma and inferior petrosal sinus sampling of adrenocorticotropic hormone (ACTH) after corticotropin releasing hormone (CRH) stimulation confirmed ACTH-dependent CD. 31251726 2019
Pituitary-dependent Cushing's disease
0.100 AlteredExpression disease BEFREE Its diagnosis relies on both biochemical tests (high-dose dexamethasone suppression test, ACTH level, corticotropin-releasing hormone test) to confirm ACTH-dependent CD and image studies (CT or MRI of chest, abdomen, and/or pelvis) for source localization. 31019854 2019
Pituitary-dependent Cushing's disease
0.100 Biomarker disease BEFREE All evaluated proteins [USP8, arginine vasopressin receptor 1b and 2, corticotropin-releasing hormone receptor, cAMP response element-binding protein (CREB), p27/kip1, cyclin E, heat shock protein 90 (HSP90), orphan nuclear receptor 4, epidermal growth factor receptor, histone deacetylase 2, glucocorticoid receptor, cyclin-dependent kinase 5 and Abelson murine leukemia viral oncogene homolog 1 enzyme substrate 1] were known to be deregulated in CD. 30844069 2019
Pituitary-dependent Cushing's disease
0.100 Biomarker disease BEFREE Clinical data was analyzed for efficacy of CRH in improving <sup>18</sup>FDG-PET detection of corticotropinomas in CD. 28986303 2018
Pituitary-dependent Cushing's disease
0.100 Biomarker disease BEFREE IPSS with desmopressin is a sensitive approach in the diagnosis of CD and has moderate accuracy in tumour lateralization, making it an alternative choice to IPSS with CRH. 29080355 2018
Pituitary-dependent Cushing's disease
0.100 AlteredExpression disease BEFREE ACTH = adrenocorticotropic hormone; BIPSS = bilateral inferior petrosal sinus sampling; CBG = corticosteroid-binding globulin; CD = Cushing disease; CRH = corticotropin-releasing hormone; CS = Cushing syndrome; Dex = dexamethasone; DST = dexamethasone suppression test; EAS = ectopic ACTH syndrome; FDA = U.S. Food & Drug Administration; HDDST = high-dose DST; IPS/P = inferior petrosal sinus to peripheral; MRI = magnetic resonance imaging; NET = neuroendocrine tumor; PET = positron emission tomography; UFC = urinary free cortisol. 28614036 2017
Pituitary-dependent Cushing's disease
0.100 Biomarker disease BEFREE Combined Administration of Ghrelin and Corticotropin-Releasing Hormone in the Diagnosis of Cushing's Disease. 26836811 2017
Pituitary-dependent Cushing's disease
0.100 Biomarker disease BEFREE Investigations suggested Cushing's disease; there was suppression after high-dose dexamethasone (<20 nmol/liter) and a 950% increase in ACTH after stimulation with CRH. 11788623 2002
Pituitary-dependent Cushing's disease
0.100 Biomarker disease BEFREE Based on existing data, the desmopressin test is regarded as an alternative to the CRH stimulation test and, when given in combination with CRH, it has been suggested to completely discriminate between patients with CD and EAS. 11932296 2002