CRP, C-reactive protein, 1401

N. diseases: 1483; N. variants: 15
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 GeneticVariation group BEFREE Diabetes, dislipidemia, and hypertension were most prevalent in patients in the upper CRP tertile. 12690081 2003
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 Biomarker group CTD_human Candesartan reduces oxidative stress and inflammation in patients with essential hypertension. 14620923 2003
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 Biomarker group BEFREE In logistic regression, the significant independent predictors for developing pre-eclampsia were fasting glucose, CRP, a family history of hypertension and the proband's mother having gestational diabetes. 15614032 2004
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 AlteredExpression group BEFREE CRP levels are associated with blood pressure, pulse pressure, and hypertension, but adjustment for life course confounding and a Mendelian randomization approach suggest the elevated CRP levels do not lead to elevated blood pressure. 15731495 2005
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 Biomarker group LHGDN Retinopathy and hypertension affect serum high-sensitivity C-reactive protein levels in Type 2 diabetic patients. 15866055 2005
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 AlteredExpression group LHGDN Fiber and C-reactive protein in diabetes, hypertension, and obesity. 15920074 2005
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 Biomarker group CTD_human Effect of doxazosin on C-reactive protein plasma levels and on nitric oxide in patients with hypertension. 16680063 2006
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 Biomarker group BEFREE Association of CRP with hypertension and the metabolic syndrome was studied in a larger series of 732 individuals, including 79 with hypertension. 17211240 2007
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 GeneticVariation group BEFREE In this study, men homozygous with the ApoE epsilon4 allele had thicker CCA-IMT, independently of Apo E epsilon2 and epsilon3 alleles, CRP, lipid variables (TG, LDL, HDL) and other CVD risk factors (smoking, hypertension, body mass index, diabetes), suggesting CCA-IMT to be modified by the ApoE epsilon4 genotype in a recessive pattern. 17426996 2007
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 AlteredExpression group BEFREE Therefore, we studied the association of single nucleotide polymorphism (SNP) in the IL-6 gene (IL6) promoter with plasma levels of fibrinogen, CRP and hypertension. 17508011 2007
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 Biomarker group BEFREE People with hypertension display an inflammatory pattern that includes increased plasma concentrations of monocyte chemoattractant protein 1 (MCP-1) and C-reactive protein (CRP) and enhanced expression of tissue factor (TF) mRNA in blood monocytes. 18339698 2008
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 Biomarker group LHGDN Association between protein-bound sialic acid and high-sensitivity C-reactive protein in essential hypertension: a possible indication of underlying cardiovascular risk. 18388037 2009
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 Biomarker group BEFREE In conclusion, serum C-reactive protein concentrations are higher in nonhypertensive offspring of parents with hypertension. 18574071 2008
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 Biomarker group LHGDN Relationship of C-reactive protein with hypertension and interactions between increased C-reactive protein and other risk factors on hypertension in Mongolian people, China. 18654021 2008
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 AlteredExpression group BEFREE A single injection of AAV-hCRP resulted in efficient and sustained hCRP expression and led to increased blood pressure 2 months after gene transfer that persisted for another 2 months. 19056836 2009
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 AlteredExpression group BEFREE CRP gene allelic variation is associated with serum CRP levels as well as hypertension in Turkish adults. 19410251 2009
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 Biomarker group BEFREE However, the combination of elevated CRP or hypertension with PH+ substantially increases the risk of CVD. 19587606 2009
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 GeneticVariation group BEFREE Association of MCP-1 -2518 A/G single nucleotide polymorphism with the serum level of CRP in Slovak patients with ischemic heart disease, angina pectoris, and hypertension. 19639050 2009
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 Biomarker group BEFREE Multivariate logistic analysis showed that diabetes was significantly associated with age (odds ratio: 1.26), overweight (1.86), high triglycerides (1.96), family history of hypertension (1.86), heart rate (1.05) and high C-reactive protein (3.59), and IFG significantly associated with age (odds ratio: 1.11), low high-density lipoprotein-cholesterol (1.80), family history of hypertension (1.60), heart rate (1.03) and high C-reactive protein (2.73). 19712989 2009
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 Biomarker group CTD_human Our study indicated that elevated plasma levels of high-sensitivity C-reactive protein and angiotensin II were positively and renin activity inversely associated with the risk of hypertension. 19770776 2010
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 Biomarker group RGD Augmented nitric oxide generation in neutrophils: oxidative and pro-inflammatory implications in hypertension. 19905982 2009
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 Biomarker group BEFREE C-reactive protein (CRP) is a risk factor or biomarker for cardiovascular diseases, including hypertension. 20157054 2010
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 AlteredExpression group BEFREE Compared with the CC genotype, variant genotypes CT and TT correlated with significantly lower levels of visfatin, hs-CRP, IL-6 and TNF-α in the SAP group (P < 0.05), with lower levels of hs-CRP and IL-6 in the UAP group (P < 0.05), and with lower levels of visfatin in the AMI group (P < 0.05) after adjustment for age, gender, smoking, hypertension, diabetes, dyslipidemia and medication. 20383745 2011
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 Biomarker group CTD_human Induction of hemeoxygenase-1 attenuates the hypertension and renal inflammation in spontaneously hypertensive rats. 20667508 2010
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 Biomarker group BEFREE Serum C-reactive protein (CRP) elevation predicts the development of heart failure in patients with hypertension. 21220701 2011