CRP, C-reactive protein, 1401

N. diseases: 1483; N. variants: 15
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 GeneticVariation disease BEFREE -717A>G polymorphism of human C-reactive protein gene associated with coronary heart disease in ethnic Han Chinese: the Beijing atherosclerosis study. 15517131 2005
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 AlteredExpression disease BEFREE C-reactive protein levels and viable Chlamydia pneumoniae in carotid artery atherosclerosis. 11739967 2001
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 AlteredExpression disease LHGDN C-reactive protein accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice. 14744975 2004
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE C-reactive protein (CRP) is a well-documented marker of atherosclerotic cardiovascular disease risk. 16266402 2005
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE C-reactive protein (CRP) is reported to be involved in the development of atherosclerosis. 16733231 2006
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE C-reactive protein (CRP) has been suggested to participate in the development of atherosclerosis, in part, by promoting endothelial dysfunction and impairing endothelial progenitor cell (EPC) survival and differentiation. 16931792 2006
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease CTD_human C-reactive protein (CRP) has been suggested to participate in the development of atherosclerosis, in part, by promoting endothelial dysfunction and impairing endothelial progenitor cell (EPC) survival and differentiation. 16931792 2006
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE C-reactive protein (CRP) has been identified as a possible factor able to promote atherosclerosis. 17433639 2008
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 GeneticVariation disease BEFREE CRP gene single nucleotide polymorphisms (SNPs) have been shown to be associated with CRP concentration; however, their independent effect on atherosclerosis has not been yet established. 19428053 2009
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE C-reactive protein (CRP), a sensitive, but nonspecific marker of inflammation has been shown to play proatherogenic roles in the process of atherosclerosis. 19624831 2009
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE C-reactive protein (CRP) plays an important role in the inflammatory process of atherosclerosis. 20670634 2010
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE C-reactive protein (CRP) has been implicated in the development of atherosclerosis. 21310412 2011
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE C-reactive protein promotes atherosclerosis by increasing LDL transcytosis across endothelial cells. 24517733 2014
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE C-reactive protein (CRP), an important inflammatory factor, plays an essential role in the pathogenesis of atherosclerosis. 30146678 2019
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE C-reactive protein (CRP) and matrix metalloproteinase (MMP)-9 are involved in the inflammation of atherosclerosis lesions. 30452971 2019
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE CRP is a biomarker of the inflammatory reaction and an important mediator of atherosclerosis. 30496036 2018
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 AlteredExpression disease BEFREE Additionally, circulating free IGF-1 levels and oral glucose tolerance tests (OGTT) were assessed in cohort 1 whereas C-reactive protein levels and degree of atherosclerosis and hepatic steatosis were studied in cohort 2. 28850155 2017
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE Adipocytokines such as tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP), adiponectin, leptin, resistin along with peroxisome proliferator activated receptor-γ (PPAR-γ) are important mediators in glucose homeostasis in association with CD36 and can be used as markers for T2DM and atherosclerosis. 21262584 2011
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE After 8 weeks of vitamin D supplementation in group DM3, the levels of 25(OH)D and HOMA-<i>β</i> increased and the levels of LDL-c, TC, HOMA-IR, FINS, CRP, RBP4, AI1, AI2, and SBP decreased significantly when compared with group DM2 (<i>P</i> < 0.05); Pearson analysis showed that serum RBP4 was positively correlated with TG, FINS, HOMA-IR, SBP, CRP, and AI and negatively correlated with 25(OH)D. In addition, multivariable logistic regression analysis showed that serum RBP4, SBP, and HDL-c were predictors for the presence of diabetic atherosclerosis. 30186876 2018
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE After adjusting for WBCC and CRP the inverse association between BRS and carotid plaque area was attenuated and did not remain significant, while both WBCC and CRP remained significantly associated with carotid plaque area, indicating that low-grade inflammation can possibly link BRS to atherosclerosis. 28376102 2017
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE After being considered a marker of acute inflammation for several decades and fruitfully used in clinical practice, CRP has been recently considered as a potential contributor to inflammatory diseases including atherosclerosis as well as a marker of cardiovascular risk. 17584094 2007
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE After evaluating its anti-oxidative and anti-inflammatory effects in cultured human cells, quercetin (0.1%, w/w in diet) was given to human CRP transgenic mice, a humanized inflammation model, and ApoE*3Leiden transgenic mice, a humanized atherosclerosis model. 21601209 2011
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE AIDM was evaluated in an inflammation model, male human C-reactive protein (CRP) transgenic mice, and an atherosclerosis model, female ApoE*3Leiden transgenic mice. 21411607 2011
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE Although female apoE knockouts develop atherosclerosis more rapidly than males, the human CRP transgene is under sex hormone control and is expressed at human levels only in males.We therefore studied only male mice. 15919817 2005
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE Although myeloperoxidase, plasma fibrinogen, cardiac troponin-I, and C-reactive protein have been considered as diagnostic markers for multiple cardiac risks, specific biomarkers for atherosclerosis have not been clearly determined yet. 31337962 2019