Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Multivariate logistic regression analysis revealed that male sex, high blood pressure, hypertriglyceridemia, BMI ≥30kg/m², age ≥50 years, sleep duration <6.5 hours, C-reactive protein ≥4.5mg/L, Beck Depression Inventory >12, and apnea-hypopnea index ≥5/h were significant risk factors of type 2 diabetes in major depression.
|
29246639 |
2019 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Tryptophan depletion in depressed patients occurs independent of kynurenine pathway activation.
|
22683764 |
2012 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Association between C-reactive protein (CRP) with depression symptom severity and specific depressive symptoms in major depression.
|
28257825 |
2017 |
Unipolar Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Increased plasma nesfatin-1 levels may be associated with corticosterone, IL-6, and CRP levels in patients with major depressive disorder.
|
29427582 |
2018 |
Unipolar Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Baseline serum C-reactive protein levels may predict antidepressant treatment responses in patients with major depressive disorder.
|
30878656 |
2019 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Prior studies suggest that the inflammatory biomarker c-reactive protein (CRP) holds promise for predicting antidepressant response in patients with major depressive disorder.
|
30102967 |
2018 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
C-reactive protein, diet quality and physical activity did not mediate the effect of obesity on major depressive disorder, and C-reactive protein mediated about 25% of the effect of major depressive disorder on adiposity.
|
31800914 |
2019 |
Unipolar Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Patients with MD exhibited higher levels of CRP, higher neutrophil and monocyte counts, lower IL-10 levels and reduced LPS-stimulated IL-6 production compared to controls (P<0.001-0.045).
|
28509904 |
2017 |
Unipolar Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Baseline CRP levels relate differentially to antidepressant treatment outcomes in persons with major depressive disorder.
|
28187400 |
2017 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate the relationship between quality of life (QoL) (physical and mental health, assessed by the SF-36) and chronic inflammation assessed using C-reactive protein (CRP) in patients with current major depressive disorder.
|
29156363 |
2018 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
While cross-sectional associations of inflammatory markers interleukin-6 (IL-6) and C-reactive protein with major depressive disorder are well established, evidence for longitudinal associations mostly comes from studies on depression symptoms, not diagnoses.
|
30819515 |
2019 |
Unipolar Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The present findings suggest that major depression is frequent in SZ patients and that increased CRP levels are associated with non-remission under antidepressants in this population.
|
31676465 |
2020 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
CRP, DII, and WBC were associated with MD.No associations were found for IgE.
|
30699847 |
2019 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study examined circulating concentrations of C-reactive protein (CRP), plasma tryptophan, kynurenine (KYN), kynurenic acid (KYNA) and quinolinic acid (QUIN) and whole blood mRNA expression of IDO in patients with major depressive disorder (MDD) compared with healthy controls (HC).
|
29787958 |
2018 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Reduced expression of glucocorticoid-inducible genes GILZ and SGK-1: high IL-6 levels are associated with reduced hippocampal volumes in major depressive disorder.
|
22832853 |
2012 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Additionally, our findings suggest a causal relationship between increased inflammation and high cholesterol in depression, as a single infusion of infliximab reduced cholesterol in TRD patients with high CRP compared to placebo.
|
30249443 |
2018 |