Heart failure
|
0.400 |
Biomarker
|
disease |
CTD_human |
The effects of atorvastatin (10 mg) on systemic inflammation in heart failure.
|
16360360 |
2005 |
Heart failure
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We collected conventional (blood pressure, cholesterol, adiposity), lifestyle, and novel (C-reactive protein, CRP) risk factors at baseline in participants from the Scottish Health Surveys (n = 5946, 44.5% men, aged 53.6 +/- 12.4 years), who were followed up over an average of 7.1 years for cardiovascular disease (CVD) events (a composite of fatal and nonfatal events incorporating acute myocardial infarction, coronary artery bypass surgery, percutaneous coronary angioplasty, stroke, heart failure).
|
19587606 |
2009 |
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study we investigated distribution of CRP, the Terminal Complement Complex (C5b-9) and macrophages (CD68) in the myocardium of patients suffering from non-ischaemic heart failure and their implication on clinical parameters.
|
19343415 |
2009 |
Heart failure
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The objective of the study was to determine whether GR haplotype 3 is associated with HF and whether this association is explained by low-grade inflammation (C-reactive protein).
|
20371666 |
2010 |
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, the effect of CRP on heart failure has not been elucidated.
|
21519150 |
2011 |
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
Serum C-reactive protein (CRP) elevation predicts the development of heart failure in patients with hypertension.
|
21220701 |
2011 |
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
After 3 months of therapy, levels of left ventricular end diastolic diameter, NT-proBNP, CRP, Th1, Th1/Th2, IFN-γ, T-bet mRNA and T-bet/GATA-3 mRNA decreased in the two CCI subgroups, but levels in the CCI intervention group were lower in comparison to the control group.
|
23413906 |
2013 |
Heart failure
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
After adjusting for traditional risk factors, high-sensitivity C-reactive protein, N-terminal pro-B-type natriuretic peptide, and high-sensitivity cardiac troponin T, higher levels of Cp were associated with HF (hazard ratio, 1.44; 95% confidence interval, 1.13-1.83) and mortality (hazard ratio, 1.38; 95% confidence interval, 1.11-1.63).
|
23861484 |
2013 |
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
Serum C-reactive protein (CRP) elevation is associated with poor clinical outcome in patients with heart failure (HF).
|
22875408 |
2013 |
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
Presence of metabolic syndrome (MS) and its components, presence of heart failure, severity of CAD symptoms, severe past ventricular arrhythmia (sustained ventricular tachycardia [sVT] or ventricular fibrillation [VF]), lower left ventricle ejection fraction, higher left ventricle mass index, higher end-diastolic volume and higher number of smoking pack-years were significantly associated with higher WBC, CRP and IL-6.
|
26864064 |
2016 |
Heart failure
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Female gender, history of heart failure or left ventricular ejection fraction <40%, and high levels (>1 mg/dL) of C-reactive protein (CRP) were independently associated with left atrial SEC/thrombosis.
|
27730663 |
2017 |
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study examined the individual and combined effect of N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity cardiac troponin T (hs-cTnT), interleukin-6 (IL-6), and hs-CRP on the prediction of heart failure incidence or progression in patients with type 2 diabetes.
|
28684396 |
2017 |
Heart failure
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
C-reactive protein levels reached a peak after 48 h. Patients with STEMI and signs of HF showed significantly higher peak CRP levels.
|
28883850 |
2017 |
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
We performed a cross-sectional analysis to investigate the relationships between inflammatory biomarkers [serum interleukin-6 (IL-6), C-reactive protein (hs-CRP) and serum amyloid A (SAA)] and median of 6 years follow-up for all-cause mortality and HF hospitalization among women with signs and symptoms of ischemia, non-obstructive CAD and preserved EF.
|
28542263 |
2017 |
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
After further adjustment for biomarkers (high-sensitivity C-reactive protein, lipoprotein-associated phospholipase A<sub>2</sub> activity, high-sensitivity troponin I, and B-type natriuretic peptide), IL-6 remained significantly associated with the risk of major adverse cardiovascular events (adj HR Q4:Q1 1.43, 95% CI 1.09-1.88) and cardiovascular death or heart failure (adj HR 1.79, 95% CI 1.22-2.63).
|
29066436 |
2017 |
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
Further analysis revealed that MedDietScore differentially affected patients' prognosis according to heart failure phenotype, with short-term impact in HFrEF and HFmrEF patients yet longer positive outcomes in HFpEF and C-reactive protein potentially mediated these relations.
|
28832572 |
2017 |
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study investigated the prospective influence of marital status, social support, depression, and C-reactive protein (CRP) on the mortality of patients with chronic HF.
|
27384414 |
2017 |
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
To describe correlations and agreement between salivary and serum B-type natriuretic peptide (BNP), C-reactive protein (CRP), interleukin (IL)-6, and IL-10 and determine which biomarkers predict worse functional class in patients with heart failure (HF).
|
27605566 |
2017 |
Heart failure
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Other predictors included ischemic etiology (HR 1.33, p=0.023), prior hospitalization for heart failure (HR 1.34, p=0.017), C-reactive protein (HR 1.04, p<0.001), and statin use (HR 0.70, p=0.016).
|
29169753 |
2018 |
Heart failure
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
After beta-blocker treatment, hs-CRP levels are associated with functional capacity in HF patients.
|
29396658 |
2018 |
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
In the multivariable analysis, the independent predictors of death were age (odds ratio (OR) 1.07, 95% confidence interval (CI) 1.02-1.13), C-reactive protein (CRP) at hospital admission (OR 1.12, 95% CI 1.04-1.21), length of the vegetation at diagnosis (OR 1.15, 95% CI 1.03-1.28), development of heart failure (OR 6.43, 95% CI 2.14-19.33), and embolic events during antimicrobial therapy (OR 12.14, 95% CI 2.11-71.89).
|
29382606 |
2018 |
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
After multivariable adjustment for baseline clinical characteristics and established biomarkers (high-sensitivity troponin I, brain-type natriuretic peptide, and high-sensitivity C-reactive protein), FGF-23 concentration in the top quartile was independently associated with an increased risk of CV death or heart failure hospitalization (adjusted hazard ratio [HR], 2.35; 95% CI, 1.82-3.02; P < .001) and its individual components.
|
29710336 |
2018 |
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
Older age, atrial fibrillation, hypertension, obesity, edema, high C-reactive protein, and smoking were risk factors for HF.
|
29934374 |
2018 |
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
In the multivariable analysis, higher vWF concentrations (middle tertile hazard ratio [HR] 4.59, 95% confidence interval [CI] 1.55-13.50 [P=0.006]; upper tertile HR 4.10, 95% CI 1.43-11.75 [P=0.009]), age≥75years (HR 5.02, 95% CI 1.53-16.49; P=0.008), heart failure (HR 2.05, 1.01-4.19; P=0.048), C-reactive protein, log<sub>2</sub> per unit increase (HR 1.29, 95% CI 1.04-1.61; P=0.021), no warfarin at discharge (HR 4.96, 95% CI 2.02-12.20; P<0.0001) and no aspirin at discharge (HR 4.41, 95% CI 1.71-11.97; P=0.002) were independently associated with an increased risk of stroke and all-cause death, whereas female sex was a protective factor (HR 0.35, 0.16-0.78; P=0.01).
|
29685722 |
2018 |
Heart failure
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our results hint towards an association of less common CRP genetic variants with increased mortality risk, depressive symptoms and peripheral CRP levels in this population of HF patients thereby suggesting a possible role of the inflammatory system as link between poor prognosis in HF and depressive symptoms.
|
29627531 |
2018 |