|
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast, C-reactive protein was not associated with current depression in cross-sectional and longitudinal analyses.
|
30819515 |
2019 |
|
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
After additionally controlling for physical activity, elevated WBC count (p = 0.002) and decreased levels of urine cortisol (p = 0.05) remained significant predictors of PTSD course, and elevated WBC count (p = 0.001), CRP (p = 0.03), and fibrinogen (p = 0.02) remained significant predictors of depression course.
|
30389462 |
2019 |
|
Depressive disorder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Study participants are then assigned into one of two study strata: either into the 'Depression with inflammation' stratum (CRP levels > 3 mg/L); or into the 'Depression without inflammation' stratum (CRP levels ≤ 3 mg/L).
|
30126458 |
2018 |
|
Depressive disorder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results confirm and extend previous findings suggesting that increased levels of CRP are associated with a later onset of depression and demonstrate that also NLR as a subclinical inflammatory marker is related to a later onset of depression.
|
29218020 |
2017 |
|
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Opioid usage was more likely to be associated with subjective measures (depression, BASDAI, BASFI) than objective measures (CRP, ESR), suggesting that pain in AS may derive from sources other than spinal inflammation alone.
|
29196383 |
2018 |
|
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
The main predictors of achievement of inactive disease, calculated with Cox-regression models, were CRP≤82.0 mg/l (OR=7.9, HR=1.17), ESR≤32 mm/h (OR=17.0, HR=0.85), ferritin ≤273 ng/ml (OR=56.5, HR=2.6), Hb>113 g/l (OR=17.0, HR=1.33), LDH≤676 U/l (OR=113.6, HR=3.2), PLT>335*109/l (OR=5.0, HR=2.5), and intensive depression of WBC in 2 weeks after the 1st TCZ infusion>11% (OR=13.0, HR=6.0) and granulocytes>12% (OR=14.0, HR=4.7).
|
29303703 |
2018 |
|
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
After adjusting for age, gender, BMI, smoking, and dyslipidemia-inducing antipsychotics, TC and LDL scores showed significant associations with depression [β = 0.13, p = 0.007; β = 0.14, p = 0.007], and with two inflammatory markers: CRP [β = 0.14, p = 0.007; β = 0.16, p = 0.007] and OPG [β = 0.14, p = 0.007; β = 0.11, p = 0.007].
|
29721726 |
2019 |
|
Depressive disorder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Inflammation is associated with depression, especially in women, and levels of C-reactive protein (CRP) and interleukin (IL)-6 predict response to antidepressant medications.
|
29489077 |
2019 |
|
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
No significant correlation was found between severity of depression and serum concentration of CRP, BDNF, and IL-2 in both the groups.
|
30405261 |
2019 |
|
Depressive disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Variants of the CRP gene thus influence circulating CRP levels and appear as independent susceptibility factors for late-life depression.
|
25603415 |
2015 |
|
Depressive disorder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In a multivariate logistic regression model, serum CRP level and FEV1 were risk factors for depression.
|
29518064 |
2018 |
|
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
There were no longitudinal associations between DGIH/BMI and depression, and adjustment for IL-6 and C-reactive protein did not attenuate associations between IR/BMI and depression; however, the longitudinal analyses may have been underpowered.
|
30854996 |
2020 |
|
Depressive disorder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-6 and CRP levels were elevated among those with lifetime depression and, among those with depression only, IL-6 methylation showed an inverse correlation with circulating IL-6 and CRP.
|
20836906 |
2011 |
|
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
The prevalence of elevated CRP (>1 mg/L) in depression was 58% (95% CI 47-69%), and the meta-analytic odds ratio for elevated CRP in depression compared with controls was 1.47 (95% CI 1.18-1.82).
|
31258105 |
2019 |
|
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Serum CRP concentration was measured prior to, and following, 6 weeks of treatment in 485 outpatients with bipolar I depression.
|
30102967 |
2018 |
|
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
What does plasma CRP tell us about peripheral and central inflammation in depression?
|
29895893 |
2018 |
|
Depressive disorder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Participants with a high CRP levels had a significantly higher rate of depression than did those with a low hs-CRP levels (25.1% vs. 19.8%, p = 0.007).
|
31377557 |
2019 |
|
Depressive disorder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Decreased UA levels showed weak negative correlation with the presence of sadness and disturbed daily activities, higher CRP levels positively correlated with severe depression and the correlation between depression and fatigue was also observed (p < 0.05).
|
30182258 |
2018 |
|
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results suggest sex-specific differences with respect to two important clinical outcomes (i.e., anxiety and CRP in women and depression and glycemic control in men).
|
28704763 |
2017 |
|
Depressive disorder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Compared with the levels in the schizophrenia group, the levels of CRP in the bipolar disorder and depression groups, the level of IFN-γ in the bipolar disorder group, and the levels of NGAL in the anxiety disorder and depression groups were significantly decreased (P < 0.05).
|
29028592 |
2018 |
|
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Both positive affect and life satisfaction were significantly related to lower CRP even after controlling for demographics and depression, in both the overall sample and chronically ill group.
|
28701268 |
2018 |
|
Depressive disorder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Removing the interaction term, CES-D trajectory was associated with inflammation: higher levels of high-sensitivity C-reactive protein were observed in the subthreshold (β = 0.57, p = .004) and increasing depressive symptoms (β = 1.36, p < .001) trajectories compared with the no depression trajectory.
|
30624288 |
2019 |
|
Depressive disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CRP SNPs rs1800947 and rs2794521 may be associated with depressive symptoms in patients with depression in a sexspecific fashion.
|
31711279 |
2019 |
|
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings suggest the C-reactive protein-depression association is symptom-specific and modified by antidepressant treatment.
|
27562420 |
2017 |
|
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-6, CRP and triglycerides are likely to be causally linked with depression, so could be targets for treatment and prevention of depression.
|
30886334 |
2019 |