|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Germline SNVs were matched against somatic tumor SNVs (i.e., tumor mutations) over twenty TCGA datasets to identify 23 germline-somatic matched, deleterious AA substitutions in coding regions for FLG, TTN, MUC4, and MUC17.
|
29778426 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
On univariate analysis no correlation was seen with either MUC1 or MUC3 and any of the clinicopathological variables including tumour grade and stage, vascular invasion and tumour type.
|
17349047 |
2007 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The median level of MUC3 and VEGF expression was greater in tumor areas compared with normal areas (P < 0.002 and P < 0.001, respectively).
|
14550470 |
2003 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In addition, a decrease in the expression of MUC3 and MUC4 was correlated with the degree of de-differentiation of the tumor.
|
12657964 |
2003 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
MUC1, MUC3 and MUC6 are expressed in normal and tumour kidney.
|
12010365 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
There is a change in the pattern of the membrane associated mucins MUC1 and MUC3, part of which is in keeping with changes described in colorectal neoplasia.
|
12171961 |
2002 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Although there was no correlation of mucin expression with tumor histology, there was a significant decrease in expression of MUC3 and MUC4 with increasing cancer stage (P < 0.05).
|
9850092 |
1998 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In colon cancers, the genetic regulation of MUC2 and MUC3 is different depending on the histological type of tumor.
|
8813081 |
1996 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
This work evaluates the expression in lung cancer of the most well characterized mucin genes (MUC1, MUC2, MUC3) and of the recently described MUC4 in lung tissues, to check a correlation between the expression of any particular gene and this tumor.
|
8694545 |
1996 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In several samples of moderately well-differentiated colon cancer, MUC2 and MUC3 showed distinct patterns of expression, but the expression level of each was reduced compared with levels in normal tissue; there was considerable tumor-to-tumor and cell-to-cell variability using both mucin antibodies and complementary DNA probes.
|
8020672 |
1994 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Analysis of The Cancer Genome Atlas database indicated that mucin-17 (MUC17) was more highly expressed in gastric cancer (GC) specimens, with favourable prognosis for patients.
|
31262330 |
2019 |
|
Malignant Neoplasms
|
0.050 |
PosttranslationalModification
|
group |
BEFREE |
Near the transcriptional start site, the DNA methylation level of MUC17-negative cancer cell lines (e.g.
|
20926598 |
2011 |
|
Malignant Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
We propose that tumours lacking expression of MUC1 and MUC3 will be more likely to metastasise, due to previously observed loss of cell-cell adhesion, and this will therefore lead to more aggressive cancers with poorer prognosis.
|
17349047 |
2007 |
|
Malignant Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Both MUC1 and MUC4 were down-regulated in gastric cancers, whereas cancer and normal tissue levels were similar for MUC3, 11, 12 and 13.
|
15375564 |
2004 |
|
Malignant Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
While MUC 3 and 7 are expressed in a small proportion of early cancers, MUC 5AC, 5B, and 6 are not expressed in laryngeal squamous cancer.
|
15243562 |
2004 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Analysis of The Cancer Genome Atlas database indicated that mucin-17 (MUC17) was more highly expressed in gastric cancer (GC) specimens, with favourable prognosis for patients.
|
31262330 |
2019 |
|
Primary malignant neoplasm
|
0.040 |
PosttranslationalModification
|
group |
BEFREE |
Near the transcriptional start site, the DNA methylation level of MUC17-negative cancer cell lines (e.g.
|
20926598 |
2011 |
|
Primary malignant neoplasm
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Both MUC1 and MUC4 were down-regulated in gastric cancers, whereas cancer and normal tissue levels were similar for MUC3, 11, 12 and 13.
|
15375564 |
2004 |
|
Primary malignant neoplasm
|
0.040 |
AlteredExpression
|
group |
BEFREE |
While MUC 3 and 7 are expressed in a small proportion of early cancers, MUC 5AC, 5B, and 6 are not expressed in laryngeal squamous cancer.
|
15243562 |
2004 |
|
Malignant tumor of colon
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
RNA blot analysis and in situ hybridization indicates that MUC17 is expressed in select pancreatic and colon cancer cell lines and in intestinal absorptive cells.
|
11855812 |
2002 |
|
Malignant tumor of colon
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Expression of MUC2 and MUC3 mRNA were both markedly decreased in poorly, moderately, and well-differentiated colon cancers but were preserved in mucinous colon cancers.
|
8813081 |
1996 |
|
Malignant tumor of colon
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Localization of mucin (MUC2 and MUC3) messenger RNA and peptide expression in human normal intestine and colon cancer.
|
8020672 |
1994 |
|
Malignant tumor of colon
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
MUC2 or MUC3 mRNA levels were increased in colloid colon cancer compared with normal colon, however in well- and moderately well-differentiated colon cancers MUC1, 2 and 3 mRNA levels were decreased.
|
7678777 |
1993 |
|
Adenocarcinoma
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Aberrant expression of membrane mucins MUC3 and MUC4 and of a mucin-associated carbohydrate tumor antigen Sialyl Le(x) in PanINs and adenocarcinoma further supports the progression model for pancreatic adenocarcinoma.
|
12657964 |
2003 |
|
Colon Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
RNA blot analysis and in situ hybridization indicates that MUC17 is expressed in select pancreatic and colon cancer cell lines and in intestinal absorptive cells.
|
11855812 |
2002 |