ovarian neoplasm
|
0.110 |
Biomarker
|
disease |
BEFREE |
Importantly, two neddylation conjugating E2 enzymes, UBE2M and UBE2F, were found to play essential roles in PTX-induced cytotoxicity and tubulin polymerization in OCCs.
|
30545630 |
2019 |
ovarian neoplasm
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association studies identify susceptibility loci for epithelial ovarian cancer in east Asian women.
|
30898391 |
2019 |
Intrahepatic Cholangiocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Knockdown of Nedd8‑conjugating enzyme UBE2M suppresses the proliferation and induces the apoptosis of intrahepatic cholangiocarcinoma cells.
|
31545502 |
2019 |
Malignant neoplasm of ovary
|
0.010 |
Biomarker
|
disease |
BEFREE |
Importantly, two neddylation conjugating E2 enzymes, UBE2M and UBE2F, were found to play essential roles in PTX-induced cytotoxicity and tubulin polymerization in OCCs.
|
30545630 |
2019 |
Primary cholangiocarcinoma of intrahepatic biliary tract
|
0.010 |
Biomarker
|
disease |
BEFREE |
Knockdown of Nedd8‑conjugating enzyme UBE2M suppresses the proliferation and induces the apoptosis of intrahepatic cholangiocarcinoma cells.
|
31545502 |
2019 |
Carcinoma, Ovarian Epithelial
|
0.010 |
Biomarker
|
disease |
BEFREE |
Importantly, two neddylation conjugating E2 enzymes, UBE2M and UBE2F, were found to play essential roles in PTX-induced cytotoxicity and tubulin polymerization in OCCs.
|
30545630 |
2019 |
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The results showed that the entire neddylation pathway, including NEDD8 (the IHC staining of NEDD8 represents the global-protein neddylation), E1 NEDD8-activating enzymes (NAE1 and UBA3), E2 NEDD8-conjugating enzymes (UBE2F and UBE2M), E3 NEDD8-ligases (MDM2, RBX1 and RNF7), and deneddylation enzymes (COPS5, UCHL1 and USP21), was overactivated in HCC.
|
29846044 |
2018 |
Non-Small Cell Lung Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Polyubiquitylation of NOXA was evaluated by <i>in vivo</i> and <i>in vitro</i> ubiquitylation assays.<b>Results:</b> UBE2F is overexpressed in non-small cell lung cancer (NSCLC) and predicts poor patient survival.
|
27591266 |
2017 |
Renal Cell Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Levels of both Nedd8 activating enzyme E1 and Nedd8-conjugating enzyme E2 were higher in ccRCC tissues and RCC cancer cells than in normal.
|
28717191 |
2017 |
Malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
While UBE2F overexpression promotes lung cancer growth both <i>in vitro</i> and <i>in vivo</i>, UBE2F knockdown selectively inhibits tumor growth.
|
27591266 |
2017 |
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Levels of both Nedd8 activating enzyme E1 and Nedd8-conjugating enzyme E2 were higher in ccRCC tissues and RCC cancer cells than in normal.
|
28717191 |
2017 |
Carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
While UBE2F overexpression promotes lung cancer growth both <i>in vitro</i> and <i>in vivo</i>, UBE2F knockdown selectively inhibits tumor growth.
|
27591266 |
2017 |
Primary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
While UBE2F overexpression promotes lung cancer growth both <i>in vitro</i> and <i>in vivo</i>, UBE2F knockdown selectively inhibits tumor growth.
|
27591266 |
2017 |
Refractory Cytopenia of Childhood
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Levels of both Nedd8 activating enzyme E1 and Nedd8-conjugating enzyme E2 were higher in ccRCC tissues and RCC cancer cells than in normal.
|
28717191 |
2017 |
Human immunodeficiency virus (HIV) II infection category B1
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found that conjugation of NEDD8 to Cullin-5 by the NEDD8-conjugating enzyme UBE2F is required for HIV Vif-mediated degradation of the host restriction factor APOBEC3G (A3G).
|
23300442 |
2012 |