PARP1, poly(ADP-ribose) polymerase 1, 142

N. diseases: 565; N. variants: 23
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE In this study, we examined whether PARP-1 is critical for DC differentiation and function using bone marrow progenitors and their migration to the lung in an ovalbumin-based mouse model of asthma. 31178661 2019
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE We have previously reported that PARP-1 plays an important role in the establishment of airway inflammation associated with asthma and ALI. 29355504 2018
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE STAT-6 and GATA-3 are reported to be central players in PARP-1-mediated eosinophilic inflammation in asthma. 28974953 2017
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE We have demonstrated a critical role for PARP in experimental asthma. 26169874 2015
CUI: C0004096
Disease: Asthma
Asthma
0.400 AlteredExpression disease BEFREE In the present study, we provide evidence for the first time that PARP-1 is activated in human asthma and that its inhibition is effective in blocking established asthma in mice. 26205779 2015
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE In addition to the role of PARP-1 in DNA repair, multiple studies have also demonstrated its involvement in several inflammatory diseases, such as septic shock, asthma, atherosclerosis, and stroke, as well as in cancer. 26339143 2015
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE Recent studies point toward the involvement of poly (ADP-ribose) polymerase-1 (PARP-1) in the pathogenesis of allergic airway inflammation, such as asthma and allergic rhinitis (AR). 24180296 2014
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE Some genetic factors that may contribute to asthma are regulated by vitamin D, such as vitamin D receptor (VDR), human leukocyte antigen genes (HLA), human Toll-like receptors (TLR), matrix metalloproteinases (MMPs), a disintegrin and metalloprotein-33 (ADAM-33), and poly(ADP-ribosyl) polymerase- 1 (PARP-1). 22532985 2012
CUI: C0004096
Disease: Asthma
Asthma
0.400 AlteredExpression disease BEFREE PARP-1 deficiency blocks IL-5 expression through calpain-dependent degradation of STAT-6 in a murine asthma model. 21276008 2011
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease BEFREE These findings suggest that PARP-1 V762A variants may be one of the factors participating in protection or susceptibility to asthma in our population. 19484672 2009
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease CTD_human Post-allergen challenge inhibition of poly(ADP-ribose) polymerase harbors therapeutic potential for treatment of allergic airway inflammation. 18261157 2008
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE Gene knockout or pharmacological inhibition of poly(ADP-ribose) polymerase-1 prevents lung inflammation in a murine model of asthma. 12594058 2003