Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, we examined whether PARP-1 is critical for DC differentiation and function using bone marrow progenitors and their migration to the lung in an ovalbumin-based mouse model of asthma.
|
31178661 |
2019 |
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We have previously reported that PARP-1 plays an important role in the establishment of airway inflammation associated with asthma and ALI.
|
29355504 |
2018 |
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
STAT-6 and GATA-3 are reported to be central players in PARP-1-mediated eosinophilic inflammation in asthma.
|
28974953 |
2017 |
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We have demonstrated a critical role for PARP in experimental asthma.
|
26169874 |
2015 |
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we provide evidence for the first time that PARP-1 is activated in human asthma and that its inhibition is effective in blocking established asthma in mice.
|
26205779 |
2015 |
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition to the role of PARP-1 in DNA repair, multiple studies have also demonstrated its involvement in several inflammatory diseases, such as septic shock, asthma, atherosclerosis, and stroke, as well as in cancer.
|
26339143 |
2015 |
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recent studies point toward the involvement of poly (ADP-ribose) polymerase-1 (PARP-1) in the pathogenesis of allergic airway inflammation, such as asthma and allergic rhinitis (AR).
|
24180296 |
2014 |
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Some genetic factors that may contribute to asthma are regulated by vitamin D, such as vitamin D receptor (VDR), human leukocyte antigen genes (HLA), human Toll-like receptors (TLR), matrix metalloproteinases (MMPs), a disintegrin and metalloprotein-33 (ADAM-33), and poly(ADP-ribosyl) polymerase- 1 (PARP-1).
|
22532985 |
2012 |
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
PARP-1 deficiency blocks IL-5 expression through calpain-dependent degradation of STAT-6 in a murine asthma model.
|
21276008 |
2011 |
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that PARP-1 V762A variants may be one of the factors participating in protection or susceptibility to asthma in our population.
|
19484672 |
2009 |
Asthma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Post-allergen challenge inhibition of poly(ADP-ribose) polymerase harbors therapeutic potential for treatment of allergic airway inflammation.
|
18261157 |
2008 |
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Gene knockout or pharmacological inhibition of poly(ADP-ribose) polymerase-1 prevents lung inflammation in a murine model of asthma.
|
12594058 |
2003 |