PARP1, poly(ADP-ribose) polymerase 1, 142

N. diseases: 565; N. variants: 23
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019158
Disease: Hepatitis
Hepatitis
0.320 Biomarker group BEFREE We analyzed immune cell populations in the liver and several lymphoid organs, such as the spleen, thymus, and bone marrow in <i>Parp2</i>-deficient mice to better define the role of PARP proteins in liver immunity and inflammation at steady state and during ConA-induced hepatitis. 28751426 2017
CUI: C0019158
Disease: Hepatitis
Hepatitis
0.320 AlteredExpression group BEFREE In the mouse model of Con A-induced hepatitis, where death of mouse hepatocytes is dependent on TRAIL and NKT (Natural Killer T) cells, PARP-1 activity was positively correlated with liver injury and hepatitis was prevented both by Nec-1 or PJ-34. 22814620 2012
CUI: C0019158
Disease: Hepatitis
Hepatitis
0.320 Biomarker group CTD_human Here, we show that hPARP-1 mice exhibit impaired survival rates accompanied by reduced hair growth and premature development of several inflammation and age-associated pathologies, such as adiposity, kyphosis, nephropathy, dermatitis, pneumonitis, cardiomyopathy, hepatitis, and anemia. 20561897 2010