Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
GM-CSF is a potent proinflammatory cytokine that plays a pathogenic role in the CNS inflammatory disease experimental autoimmune encephalomyelitis.
|
22837488 |
2012 |
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Unexpectedly, GM-CSF-deficient C3HeB/FeJ mice were fully susceptible to EAE because IL-17 activity compensated for the loss of GM-CSF during induction of spinal cord-targeted disease.
|
28405624 |
2017 |
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast, prophylactic anti-GM-CSF-mAb treatment prevented EAE-I and -II.
|
30216414 |
2018 |
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pathogenic TH cells in EAE must produce the pro-inflammatory cytokine granulocyte-macrophage colony stimulating factor (GM-CSF).
|
24699451 |
2014 |
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Experimental autoimmune encephalomyelitis (EAE) progressed normally when either classical dendritic cells (cDCs) or neutrophils lacked GM-CSF responsiveness.
|
26341401 |
2015 |
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We report that lymphatic vessels near the cribriform plate undergo lymphangiogenesis in a VEGFC - VEGFR3 dependent manner during experimental autoimmune encephalomyelitis (EAE) and drain both CSF and cells that were once in the CNS parenchyma.
|
30651548 |
2019 |
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In vivo, the protective effects of TSA on EAE mice are correlated with diminished inflammatory infiltration, demyelination, and GM-CSF-producing CD4<sup>+</sup> T cells in the spinal cord and selectively increased regulatory T (Treg) cell frequencies in both the spinal cord and spleen.
|
31845175 |
2019 |
Encephalomyelitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results reveal that increased CSF PDGF concentration correlates with decreased short afferent inhibition in the motor cortex in MS patients and decreased GABAergic activity in EAE.
|
29392518 |
2019 |
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Likewise, a TTV comprised of GM-CSF and PLP139-151 was a tolerogen in the SJL model of EAE.
|
22208499 |
2011 |
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we show that <i>Cblb</i> knockout mice demonstrated significantly exacerbated severity of experimental autoimmune encephalomyelitis (EAE), augmented T cell infiltration into the central nervous system (CNS) and strongly increased production of GM-CSF in T cells <i>in vitro</i> and <i>in vivo</i>.GM-CSF neutralization demonstrated that the increased susceptibility of <i>Cblb</i><sup>-/-</sup> mice to EAE was dependent on GM-CSF.
|
30349541 |
2018 |
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In vivo, RGC-32<sup>-/-</sup> mice display an attenuated experimental autoimmune encephalomyelitis phenotype accompanied by decreased CNS inflammation and reduced frequency of IL-17- and GM-CSF-producing CD4<sup>+</sup> T cells.
|
28356385 |
2017 |
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In experimental autoimmune encephalomyelitis (EAE), auto-reactive helper T (Th) cells instigate CNS inflammation by acting on myeloid cells via the production of granulocyte-macrophage colony-stimulating factor (GM-CSF).
|
26431942 |
2015 |
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data shows that DRD5-deficiency confined to DCs in EAE mice resulted in reduced frequencies of CD4<sup>+</sup> T-cell subsets with inflammatory potential in the central nervous system, including not only Th1 and Th17 cells but also granulocyte-macrophage colony-stimulating factor producers.
|
29619030 |
2018 |
Encephalomyelitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
MRI lesions, cytokines in blood, and CSF at onset of ADS or EAE, as well as histopathological features of brain lesions were compared.
|
31785610 |
2019 |
Encephalomyelitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Down-regulation of TUG1 improved mice behavior, reduced granulocyte-macrophage colony stimulating factor (GM-CSF) level, decreased the levels of pro-inflammatory cytokines including tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin (IL)-6 and IL-17, and increased IL-10 in EAE mice.
|
31394128 |
2019 |
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
RGC-32<sup>-/-</sup> mice display an attenuated experimental autoimmune encephalomyelitis phenotype that is accompanied by decreased central nervous system inflammation and reductions in IL-17- and GM-CSF-producing CD4<sup>+</sup> T cells.
|
31250246 |
2019 |