CSF2, colony stimulating factor 2, 1437

N. diseases: 1028; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.510 Biomarker disease RGD Herein we have studied, using RT-competitive PCR, the expression of GM-CSF mRNA during the early steps of pulmonary fibrosis development after intra-alveolar instillation of bleomycin, a well-established experimental model of this lesion. 9881949 1998
CUI: C0242422
Disease: Parkinsonian Disorders
Parkinsonian Disorders
0.240 Biomarker group RGD Therapeutic efficacy of intranasally delivered mesenchymal stem cells in a rat model of Parkinson disease. 21291297 2011
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.230 Biomarker disease RGD Antibody to granulocyte macrophage colony-stimulating factor reduces the number of activated tissue macrophages and improves left ventricular function after myocardial infarction in a rat coronary artery ligation model. 21326109 2011
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal
0.210 ModifyingMutation disease RGD Hemodynamic forces regulate mural macrophage infiltration in experimental aortic aneurysms. 15010288 2004
CUI: C1535939
Disease: Pneumocystis jiroveci pneumonia
Pneumocystis jiroveci pneumonia
0.210 Biomarker disease RGD Effects of decreased calmodulin protein on the survival mechanisms of alveolar macrophages during Pneumocystis pneumonia. 19487471 2009
CUI: C0006272
Disease: Bronchiolitis Obliterans
Bronchiolitis Obliterans
0.200 Biomarker disease RGD Chronic aspiration of gastric fluid induces the development of obliterative bronchiolitis in rat lung transplants. 18557728 2008
CUI: C0037116
Disease: Silicosis
Silicosis
0.200 Biomarker disease RGD Cross-talk of the related bioactivity mediators in serum after injection of soluble TNF-α receptor on silicosis model of rats. 21505002 2011
CUI: C0282488
Disease: Interstitial Cystitis
Interstitial Cystitis
0.200 Biomarker disease RGD Multiplex analysis of urinary cytokine levels in rat model of cyclophosphamide-induced cystitis. 18848347 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.350 Biomarker disease PSYGENET We report results of a case-control WGA study in schizophrenia, examining approximately 500 000 markers, which revealed a strong effect (P=3.7 x 10(-7)) of a novel locus (rs4129148) near the CSF2RA (colony stimulating factor, receptor 2 alpha) gene in the pseudoautosomal region. 17522711 2007
CUI: C0034050
Disease: Pulmonary Alveolar Proteinosis
Pulmonary Alveolar Proteinosis
0.300 Biomarker disease MGD Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology. 8202532 1994
CUI: C0034050
Disease: Pulmonary Alveolar Proteinosis
Pulmonary Alveolar Proteinosis
0.300 Biomarker disease MGD Granulocyte-macrophage colony-stimulating factor-deficient mice have impaired resistance to blood-stage malaria. 11119498 2001
CUI: C0034050
Disease: Pulmonary Alveolar Proteinosis
Pulmonary Alveolar Proteinosis
0.300 Biomarker disease MGD Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis. 8171324 1994
CUI: C0034050
Disease: Pulmonary Alveolar Proteinosis
Pulmonary Alveolar Proteinosis
0.300 Biomarker disease MGD Characterization of ovarian function in granulocyte-macrophage colony-stimulating factor-deficient mice. 10684813 2000
CUI: C0034050
Disease: Pulmonary Alveolar Proteinosis
Pulmonary Alveolar Proteinosis
0.300 Biomarker disease MGD Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease. 19196868 2009
CUI: C0034050
Disease: Pulmonary Alveolar Proteinosis
Pulmonary Alveolar Proteinosis
0.300 Biomarker disease MGD Fertility impairment in granulocyte-macrophage colony-stimulating factor-deficient mice. 9915988 1999
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute
0.400 AlteredExpression disease LHGDN In vitro studies demonstrated that leptin increased AML blast release of interleukin (IL) 1beta, IL6, tumor necrosis factor (TNF) alpha and granulocyte-macrophage colony-stimulating factor (GM-CSF). 12031914 2002
CUI: C0021368
Disease: Inflammation
Inflammation
0.310 Biomarker phenotype LHGDN This review summarizes the evidence supporting a major role for GM-CSF in inflammation and autoimmunity and its functions as major regulator governing granulocyte and macrophage lineage populations at all stages of maturation. 16167889 2005
CUI: C0024305
Disease: Lymphoma, Non-Hodgkin
Lymphoma, Non-Hodgkin
0.310 AlteredExpression disease LHGDN Induction of apoptosis and bcl-2 expression in acute lymphoblastic leukaemia and non-Hodgkin's lymphoma in children. 11855781 2001
CUI: C0034050
Disease: Pulmonary Alveolar Proteinosis
Pulmonary Alveolar Proteinosis
0.300 Biomarker disease LHGDN Elevated IL-10 inhibits GM-CSF synthesis in pulmonary alveolar proteinosis. 14567558 2003
CUI: C0034050
Disease: Pulmonary Alveolar Proteinosis
Pulmonary Alveolar Proteinosis
0.300 Biomarker disease LHGDN High-affinity autoantibodies specifically eliminate granulocyte-macrophage colony-stimulating factor activity in the lungs of patients with idiopathic pulmonary alveolar proteinosis. 14512323 2004
CUI: C0023418
Disease: leukemia
leukemia
0.100 AlteredExpression disease LHGDN GM-CSF does not increase CD20 antigen expression on chronic lymphocytic leukemia lymphocytes. 15927668 2005
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.070 GeneticVariation disease LHGDN The GM-CSF genotype is an important genetic marker predicting an individual's predisposition to atopic dermatitis. 13679820 2003
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease
0.070 GeneticVariation disease LHGDN This study suggests that polymorphisms in both CSF2 and IL8 may play a role in the pathogenesis of COPD, at least in highly exposed populations. 17681858 2008
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.050 Biomarker disease LHGDN Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor promote malignant growth of cells from head and neck squamous cell carcinomas in vivo. 16912178 2006
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia
0.040 AlteredExpression disease LHGDN Contribution of GM-CSF and IL-8 to the CD44-induced differentiation of acute monoblastic leukemia. 17914409 2008