|
Ulcerative Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Pooled rates of CSF-CR in patients with UC and CD treated with placebo were 9.7% and 19.1%, respectively.
|
31504528 |
2020 |
|
Drug abuse
|
0.010 |
Biomarker
|
group |
BEFREE |
Perinatal SDH hampers CSF absorption, possibly leading to BEH and chronic SDH, with a high risk of false accusations of abuse.
|
31637736 |
2020 |
|
Fatigue
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The variables age, sex, facial nerve palsy, generalized inflammation symptoms (fever, headache, neck-stiffness and/or fatigue), duration of symptoms, <i>Borrelia</i> antibodies in CSF, <i>Borrelia</i> antibody index (AI), CSF white blood cells (WBC), CSF protein and detection of the genospecies <i>Borrelia garinii</i> by PCR were included in simple and multivariable regression analyses to study the associations with the CXCL13 level.
|
31573360 |
2020 |
|
Lymphohistiocytosis, Hemophagocytic
|
0.010 |
Biomarker
|
disease |
BEFREE |
CD8+ T cells and the IL-33/ST2 axis remained essential mediators of disease; however, IFNγ-independent HLH immunopathology correlated with a 10-15-fold increase in neutrophilia (P < 0.001) and an altered cytokine milieu dominated by IL-6, IL-1β, and granulocyte-macrophage colony-stimulating factor (GM-CSF) (P < 0.05).
|
31400073 |
2020 |
|
Measles
|
0.010 |
Biomarker
|
disease |
BEFREE |
We tested on OD data of 51 CSF/serum sample pairs, measured with EUROIMMUN AG (Lübeck, Germany) ELISA tests for antibody determination in CSF, as part of INSTAND e.V. proficiency survey tests for the MRZH reaction (Measles, Rubella, Varicella zoster, Herpes simplex virus).
|
31678266 |
2020 |
|
Pseudodementia
|
0.010 |
Biomarker
|
disease |
BEFREE |
The unfamiliar symptom presentation including fluctuations in cognitive performance, affective symptoms, cerebrospinal fluid (CSF) biomarkers, which were at first inconspicuous, and a former suspected diagnosis of dissociative pseudodementia, altogether brought considerable uncertainty to the involved health-care professionals.
|
31203704 |
2020 |
|
Stuttering
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Practitioners should be aware that iNPH can present with stuttering, and that CSF drainage can improve stuttering in select circumstances.
|
31805405 |
2020 |
|
Subdural Effusion
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
The complications included seizure (2.4%), CSF leak (2.4%), and subdural effusion (2.4%).
|
31792687 |
2020 |
|
Tuberous Sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
SEGAs may lead to impaired circulation of CSF resulting in hydrocephalus and raised intracranial pressure in patients with TSC.
|
31834371 |
2020 |
|
Mucopolysaccharidosis Type IIIA
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Enzyme activity did not inform on disease severity, with no measurable activity in CSF and activity approaching normal in MPS IIIA plasma.
|
31104888 |
2020 |
|
Hypopigmentation disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Administration of <b>20</b> resulted in no skin/fur color change in a 13-day mouse hypopigmentation study and demonstrated robust and sustained reduction of CSF and brain Aβ<sub>40</sub> levels in rat and monkey pharmacodynamic models.
|
31589043 |
2020 |
|
Desquamative interstitial pneumonia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Since smoking increases expression of pulmonary granulocyte/macrophage-colony stimulating factor (GM-CSF) and GM-CSF stimulates proliferation and activation of AMs, we hypothesized chronic exposure of mice to increased pulmonary GM-CSF would recapitulate DIP.
|
31310562 |
2020 |
|
meningitis/encephalitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
All CSF samples sent to the microbiology laboratory for suspicion of meningitis and/or encephalitis, with CSF cells count > 5 cells/μL, were tested by meningitis/encephalitis multiplex PCR assay.
|
31720944 |
2020 |
|
ALBINOIDISM, OCULOCUTANEOUS, AUTOSOMAL DOMINANT
|
0.010 |
Biomarker
|
disease |
BEFREE |
Administration of <b>20</b> resulted in no skin/fur color change in a 13-day mouse hypopigmentation study and demonstrated robust and sustained reduction of CSF and brain Aβ<sub>40</sub> levels in rat and monkey pharmacodynamic models.
|
31589043 |
2020 |
|
Child attention deficit disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Baseline CSF biomarkers (amyloid beta (Aβ) 1-42, Aβ42/40, Tau, and pTau181), interpreted according to the ES, were used to estimate time to progression from the MCI stage of AD to ADD, conditional on age, gender, APOE ε4 genotype, and Mini Mental State Examination score in 144 MCI subjects, using the Extended Cox Model; the subjects were followed-up until they developed dementia or until they had been cognitively stable for at least 2 years.
|
30611311 |
2019 |
|
Back Pain
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Implication of microglia activation and CSF-1/CSF-1Rpathway in lumbar disc degeneration-related back pain.
|
30326776 |
2019 |
|
Pneumonia, Bacterial
|
0.010 |
Biomarker
|
group |
BEFREE |
Airway recombinant GM-CSF administration thus shows therapeutic promise to accelerate neonatal pulmonary immunity, protecting against bacterial pneumonia.
|
31453341 |
2019 |
|
Cataplexy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Best MSLT cutoffs were obtained by receiver operating characteristic (ROC) curve analysis by contrasting among patients with available CSF hcrt-1 assay (n = 228) with vs without CSF hcrt-1 deficiency, and further validated in patients without available CSF hcrt-1 against cataplexy (n = 129).
|
31405906 |
2019 |
|
Brain Ischemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Recent studies have provided evidence that cortical brain ischemia may influence choroid plexus function, and such communication may be mediated by either traditional CSF circulation pathways and/or a possible glymphatic pathway.
|
31500523 |
2019 |
|
Cerebrovascular Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
CSF-E prevalence varied substantially (9.0-38.9%) and was higher in patients with cerebrovascular disorders, HIV-associated dementia and white matter abnormalities.
|
30531317 |
2019 |
|
Chikungunya Fever
|
0.010 |
Biomarker
|
disease |
BEFREE |
The newborn progressed with cutaneous lesions and irritability 2 months after vertical transmission, when chikungunya virus was detected in the infant's CSF by a molecular diagnostic test (real-time polymerase chain reaction).
|
30657982 |
2019 |
|
Spinal meningocele
|
0.010 |
Biomarker
|
disease |
BEFREE |
The study was conducted on four infants with a mean age of 7 months, who underwent repairs for CSF leaks associated with congenital lesions like meningocele or meningoencephalocele, using the Hadad flap.
|
30968177 |
2019 |
|
Deglutition Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
The most consistent indications for surgical intervention in early hydrocephalus were CSF leak from the back (92%), progressive ventricular enlargement (89%), and brainstem symptoms, including apnea/bradycardia (81%), stridor (81%), and dysphagia (81%).
|
31470398 |
2019 |
|
Dengue Fever
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Cytokine analyses demonstrated that levels of interleukin (IL)-6, IL-4, IL-13, IL-1β, interferon gamma (IFN-γ), and granulocyte-macrophage colony-stimulating factor (GM-CSF) were significantly higher in DHF patients compared to DF patients (p< 0.001).
|
31521850 |
2019 |
|
Encephalitis, St. Louis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
After adjustment for multiple comparisons, GCF levels of interleukin (IL)-1β, IL-8, granulocyte colony-stimulating factor (G-CSF), interferon-γ and monocyte chemoattractant protein-1 were significantly higher, whereas the levels of granulocyte-macrophage colony-stimulating factor were significantly lower in jSLE patients.
|
30563424 |
2019 |