CSF2, colony stimulating factor 2, 1437

N. diseases: 1028; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030193
Disease: Pain
Pain
0.330 Biomarker phenotype BEFREE Our findings describe a novel bone cancer pain mechanism and provide a new insight into the physiological and pathological functions of GM-CSF.<b>SIGNIFICANCE STATEMENT</b> It has been reported that granulocyte-macrophage colony-stimulating factor (GM-CSF) plays a key role in bone cancer pain, yet the underlying mechanisms involved in the GM-CSF-mediated signaling pathway in nociceptors is not fully understood. 31015342 2019
CUI: C0030193
Disease: Pain
Pain
0.330 Biomarker phenotype BEFREE Granulocyte-macrophage colony-stimulating factor (GM-CSF) is well described in inflammation-induced pain, and early-phase clinical trials evaluating its antagonism have exemplified its importance as a peripheral pain target. 29351125 2018
CUI: C0030193
Disease: Pain
Pain
0.330 Biomarker phenotype BEFREE Compared to ANNA1 alone, CRMP5 neuropathy has a higher prevalence of pain (79% vs 46%, <i>p</i> = 0.008), asymmetric polyradiculoneuropathy (54% vs 12%, <i>p</i> < 0.001), and inflammatory spinal fluids (elevated CSF protein or nucleated cell count 92% vs 60%, <i>p</i> = 0.022). 29222126 2018
CUI: C0030193
Disease: Pain
Pain
0.330 Biomarker phenotype CTD_human Severe atypical neuropathy associated with administration of hematopoietic colony-stimulating factors and vincristine. 8622042 1996