CSF2, colony stimulating factor 2, 1437

N. diseases: 1028; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Anti-N-Methyl-D-Aspartate Receptor Encephalitis
0.090 Biomarker disease BEFREE (3) Laboratory examinations: Anti-NMDA receptor IgG in CSF was detected in two patients (2/12, 16.67%), with one patient presented with anti-NMDAR encephalitis associated symptoms. 30529926 2019
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.370 Biomarker group BEFREE (c) Some, but not all, lung carcinomas produced this cytokine, and a close correlation was found between the production of GM-CSF and the number of CD1a+ LC infiltrating these tumors. 7679411 1993
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE (c) Some, but not all, lung carcinomas produced this cytokine, and a close correlation was found between the production of GM-CSF and the number of CD1a+ LC infiltrating these tumors. 7679411 1993
CUI: C0007815
Disease: Cerebrospinal Fluid Rhinorrhea
Cerebrospinal Fluid Rhinorrhea
0.040 Biomarker phenotype BEFREE 116 cases were identified.The location of leaks was 91 CSF rhinorrhea and 28 CSF otorrhea (3 both). 31604132 2020
CUI: C2921627
Disease: Clinically isolated syndrome
Clinically isolated syndrome
0.040 Biomarker disease BEFREE 34 CIS subjects were enrolled and underwent cerebrospinal fluid oligo-clonal bands (CSF-OCB) evaluation. 30953954 2019
CUI: C0234985
Disease: Mental deterioration
Mental deterioration
0.100 Biomarker phenotype BEFREE 3446 individuals (1154 AD cases and 2292 controls) were included in the analyses of AD risk, 1400 individuals (cognitively normal = 747, AD = 653) in the CSF biomarker analyses, and 861 individuals in the analyses of cognitive decline. 30792413 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 Biomarker disease BEFREE 3446 individuals (1154 AD cases and 2292 controls) were included in the analyses of AD risk, 1400 individuals (cognitively normal = 747, AD = 653) in the CSF biomarker analyses, and 861 individuals in the analyses of cognitive decline. 30792413 2019
CUI: C0393639
Disease: Hashimoto's encephalitis
Hashimoto's encephalitis
0.080 Biomarker disease BEFREE 375 children were tested for AIE 2011-17 (median age 11.1 years; 54% girls); 18 children (5%) had AIE antibodies (percentage tested positive): CSF GAD<sub>65</sub>-IgG (3.1%), plasma NMDAR-IgG (2.8%), CSF NMDAR-IgG (1.8%), plasma GAD<sub>65</sub>-IgG (1.0%), and plasma CASPR2-IgG (0.4%). 31128894 2019
CUI: C0751072
Disease: Frontotemporal Lobar Degeneration
Frontotemporal Lobar Degeneration
0.060 Biomarker disease BEFREE 4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration. 31616982 2020
CUI: C3811918
Disease: GRN-related frontotemporal dementia
GRN-related frontotemporal dementia
0.030 Biomarker disease BEFREE 4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration. 31616982 2020
CUI: C0014065
Disease: Congenital cerebral hernia
Congenital cerebral hernia
0.040 GeneticVariation disease BEFREE 78 (72.22%) cases had an associated encephalocele with the CSF leak. 31604132 2020
CUI: C4551722
Disease: Encephalocele
Encephalocele
0.020 GeneticVariation disease BEFREE 78 (72.22%) cases had an associated encephalocele with the CSF leak. 31604132 2020
CUI: C0751731
Disease: Intracranial Hypotension, Essential
Intracranial Hypotension, Essential
0.100 Biomarker disease BEFREE 92 patients with SIH were identified and 62 of these patients underwent CSF volume provocation maneuvers. 31639606 2019
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.380 Biomarker disease BEFREE Colorectal cancers are known to be infiltrated by dendritic cells (DC) and neoplastic cells have been shown to produce GM-CSF. 10738251 2000
CUI: C4727069
Disease: Advanced Renal Cell Carcinoma
Advanced Renal Cell Carcinoma
0.010 GeneticVariation disease BEFREE Advanced renal cell carcinoma treated with granulocyte-macrophage colony-stimulating factor gene therapy: a clinical course of the first Japanese experience. 12225344 2002
CUI: C0349639
Disease: Juvenile Myelomonocytic Leukemia
Juvenile Myelomonocytic Leukemia
0.400 Biomarker disease BEFREE Chronic myelomonocytic leukemia requires granulocyte-macrophage colony-stimulating factor for growth in vitro and in vivo. 12384142 2002
Human immunodeficiency virus (HIV) II infection category B1
0.040 Biomarker disease BEFREE Human immunodeficiency virus type 1 infection inhibits granulocyte-macrophage colony-stimulating factor-induced activation of STAT5A in human monocyte-derived macrophages. 14610185 2003
CUI: C0034050
Disease: Pulmonary Alveolar Proteinosis
Pulmonary Alveolar Proteinosis
0.300 Biomarker disease BEFREE Pulmonary alveolar proteinosis (PAP) is an autoimmune disorder characterized by neutralizing autoantibodies to granulocyte-macrophage colony stimulating factor (GM-CSF). 16337108 2006
CUI: C0034050
Disease: Pulmonary Alveolar Proteinosis
Pulmonary Alveolar Proteinosis
0.300 Biomarker disease BEFREE Pulmonary alveolar proteinosis (PAP) is a lung disease characterized by a deficiency of functional granulocyte macrophage colony-stimulating factor (GM-CSF) resulting in surfactant accumulation and lipid-engorged alveolar macrophages. 21036914 2011
CUI: C0020877
Disease: Ileitis
Ileitis
0.030 Biomarker disease BEFREE Ileitis was induced in C15KO mice via GM-CSF Ab administration followed by nonsteroidal antiinflammatory drug (NSAID) exposure, and expression of CCL25, CCR9, FOXP3, intracellular cytokines, and RALDH2 was determined in IEC and immune cell populations. 21381154 2011
CUI: C3241937
Disease: Nonalcoholic Steatohepatitis
Nonalcoholic Steatohepatitis
0.310 AlteredExpression disease BEFREE Nonalcoholic steatohepatitis (NASH), when compared with simple steatosis (SS), significantly increases the expression of TGFB1 (6.8, p<0.005), angiotensin I-converting enzyme (ACE) (2.1, p<0.007), LAMA1 (2.1, p<0.007), SERPINB2 (2.1, p<0.007), CSF2 (2.5, p<0.002), IL1A (2.5, p<0.005), IL3 (2.1, p<0.007), IL4 (2.1, p<0.007), LIF (2.1, p<0.007), and MMP1 (2.1, p<0.007), and decreases the transcript levels of genes involved in the negative regulation of cell-death pathways. 21664615 2011
CUI: C0349639
Disease: Juvenile Myelomonocytic Leukemia
Juvenile Myelomonocytic Leukemia
0.400 Biomarker disease CTD_human Juvenile myelomonocytic leukemia is a lethal disease of children characterized by hypersensitivity of hematopoietic progenitors to granulocyte macrophage-colony stimulating factor. 22315502 2012
CUI: C0349639
Disease: Juvenile Myelomonocytic Leukemia
Juvenile Myelomonocytic Leukemia
0.400 Biomarker disease BEFREE Juvenile myelomonocytic leukemia is a lethal disease of children characterized by hypersensitivity of hematopoietic progenitors to granulocyte macrophage-colony stimulating factor. 22315502 2012
CUI: C0349639
Disease: Juvenile Myelomonocytic Leukemia
Juvenile Myelomonocytic Leukemia
0.400 Biomarker disease BEFREE Juvenile myelomonocytic leukemia (JMML) is characterized by hypersensitivity to granulocyte-macrophage colony-stimulating factor (GM-CSF). 23696637 2013
CUI: C0349639
Disease: Juvenile Myelomonocytic Leukemia
Juvenile Myelomonocytic Leukemia
0.400 Biomarker disease BEFREE Juvenile myelomonocytic leukaemia (JMML) is an aggressive myeloproliferative neoplasm in children characterized by granulocyte macrophage colony-stimulating factor (GM-CSF) hypersensitivity and resistance to chemotherapy. 24469048 2015